Wave Length And Action Potentials

Over the last two decades monophasic action potential (MAP) recording has matured into a technique that provides a link between basic and clinical electrophysiology. International experts present exciting data on MAP recording techniques, the mechanism and interpretation of MAPs, and novel aspects of repolarization-related arrhythmias.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling. This is an expanded and fully-updated second edition, reflecting all the recent advances in this field. Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential – and limitations – for new developments in the field, including new technology such as non-linear optics, advanced microscope designs and genetically encoded voltage sensors. Membrane Potential Imaging in the Nervous System and Heart is ideal for neurologists, electro physiologists, cardiologists and those who are interested in the applications and the future of membrane potential imaging.

Available again: a landmark collection on sensation and perception that remains influential.

A new guide to the mechanisms and principles behind the world’s most common abnormal heart rhythm Affecting 30 million or more people across the globe, atrial fibrillation is one of the most prevalent – and yet misapprehended – issues facing modern cardiology. Its potential causes and optimal treatment strategies are matters of some conjecture in the medical community, where ongoing research has yielded findings that can prove challenging to those not familiar with the complex physiology at the root of the condition. Recognizing these concerns, distinguished electrophysiologist Peter Spector has designed Understanding Atrial Fibrillation as a means by which to equip clinicians with the data and analytic tools needed to develop a better grasp of this arrhythmia’s full nature. The book begins by providing a detailed explanation of atrial fibrillation’s causal mechanisms and builds its exploration from there. Working toward an up-to-date knowledge of the mapping and ablation of atrial fibrillation, its chapters assess the experimental data that has shaped current thoughts on the condition and then outline the best methods with which to interpret that rich but potentially difficult information. This revelatory new guide: Explores hypotheses of multiple drivers and mechanisms co-existing in individual patients Addresses common misperceptions and inaccurate views about atrial fibrillation Describes the basic physiology of atrial fibrillation’s propagation and reentry Explores the various mechanisms and higher-order dynamics of fibrillation Discusses how to intervene and alter atrial physiology to prevent fibrillation Understanding Atrial Fibrillation is truly an invaluable resource for physicians, fellows, residents, electrophysiology lab staff, and all other practitioners involved in the diagnosis and treatment of atrial fibrillation.

They are each directed toward the understanding of a biological principle, with a particular emphasis on human biology.