Yearbook Of Cell And Tissue Transplantation 1996 1997

Cell and tissue transplantation is one of the most exciting and rapidly expanding areas in medicine. This first edition of the Yearbook of Cell and Tissue Transplantation summarizes the latest advances in this revolutionary field, including developments in tissue engineering and transplantation of hybrid organs and tissues, while reviewing those data which, while not new, add to the usefulness of this work as a comprehensive reference. The justification for yearbooks is greater than ever as we approach the third millennium, overwhelmed with information. In view of the important and rapid changes occurring in this area, a new edition of this yearbook will appear periodically. The editors' careers at Harvard Medical School guarantee the quality of this book. The authors, too, are uniformly drawn from the highest rank of an unusually dedicated and heterogeneous professional group. from the Foreword by Thomas E. Starzl, Honorary President, The Cell Transplant Society: `No major topic in the global field is left uncovered ... the result will be a feast for those already well informed, and a life raft for those who are not.'

This is a time ofexcitement and progress in the field ofxenotransplantation. The work described in this book traces the development of the science of cross-spe cies transplantation, summarizes the current state ofour knowledge, and focuses on approaches directed toward future clinical application. The important question is not whether xenotransplantation will succeed, but rather how and under what circumstances xenografts will provide predictable enough results to warrant clinical application. The fact that the best results to date in clinical xenografting were achieved over three decades ago should not be a matter of discouragement, but rather a stimulus to apply new approaches to this area of work. The shortage of human organs for transplantation is cited frequently as the driving force behind the increased interest in xenotransplantation. This shortage is an undeniable fact, but there are additional potential advantages of xenotrans plantation, such as the ability to schedule replacement surgery on an elective basis and the modification of animals, organs, and tissues to improve acceptabil ity in the human host. The advances in the basic science ofxenotransplantation outlined in this book give hope that the immunologic barriers to xenotransplantation will be overcome and that transplanted organs and tissues will succeed consistently in humans. However, if our experience with human allografts provides an analogy, we may anticipate that clinical progress in xenografts will be plagued by failures and rewarded by successes, often without a complete understanding of the mechan isms involved.

Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.

This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology, orthopedics and infectious diseases. The book emphasizes clinical advances as proof of concept in cell therapy based on the revolutionizing observation that regeneration can occur throughout the body even in highly differentiated organs like the heart and the neuronal system. It provides examples of breakthroughs in the clinical implementation of adult stem cell therapy.

Describes research technology for the growth and differentiation of all 12 types of the primary hematopoietic cells that develop into the various types of blood cells. Also provides background information, discusses current and future clinical applications of large-scale culture methods, and considers regulatory and ethical implications associated with using human and fetal tissues. The 13 studies include treatments of hematopoietic stem and progenitor cells, monocytes and macrophages, isolating and culturing human dendritic cells, purifying and culturing erythroid progenitor cells, the in vitro development of megakaryocytes and platelets, the mature polyclonal and antigen- specific cell expansion of T-lymphocytes, and in vitro T- lymphopoiesis. They are not indexed. Annotation copyrighted by Book News, Inc., Portland, OR

Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing. Describes challenges in the diagnosis, management and treatment of autoimmune diseases Highlights major difficulties in the diagnosis and management of autoimmune diseases Reflects important remediable deficiencies in current management Meets the needs of basic scientists, clinicians and translational scientists and industry partners

After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.