Actinobacteria

This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.

This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes

This book describes isolated actinobacteria from different environments, and how these can be used to bioremediate heavy metals and pesticides in contaminated sites. It also describes how free-living actinobacteria acquire the capability to produce nodules in plants and how this factor could be important for accelerating the degradation of pesticides in soils or slurries. Some chapters show how actinobacteria can be used to produce industrial enzymes and metabolites under different physicochemical conditions for use in the food industry. This book will interest professionals involved with waste management, environmental protection, and pollution abatement.

This book provides in-depth insights into the diversity of actinobacteria, their various medical aspects, and their biotechnological applications. It is aimed at graduate students and researchers working with actinobacteria who need to know about recent advances in their research fields. The book, which is divided into four sections, contains 13 chapters that review the most recent methods, discuss various applications of actinobacteria, introduce some interesting results, and explore future prospects for the topics covered.

Through this book, the readers will learn about the different aspects of Actinobacteria- beginning with its ecology and occurrence, to the ways of its adaptation to harsh climates, and finally to its practical applications. The book also presents methods of identifying and characterizing this diverse group of bacteria through advanced techniques like MALDI-TOF, 16S rRNA analysis, etc. Different chapters describe the various biotechnological applications of Actinobacteria, including bioremediation, secondary metabolite production, and in producing antibiotics, anti-cancer therapeutics. It also provides insights into the applications in agriculture and forestry by inhibiting plant pathogenic bacteria's growth.

This book summarizes the basics of actinobacteria, from microbiology to synthetic biology. It focuses on diversity, NRPS, sesquiterpenes, lantipeptide, bioinformatics apparatuses, cloning, CRISPR, reverse engineering, FDA supported medications, and marine actinobacteria. It also covers the latest trends in drug discovery from actinobacteria, and introduces several recently developed bioinformatics and synthetic biology tools to explore new antibiotics from actinobacteria. Many natural products such as polyketides, isoprenoids, phenazines, peptides, indolocarbarbazoles, sterols, and others have been isolated and characterized from actinobacteria. Some products are synthesized by the non-ribosomal peptide synthetases (NRPSs), polyketide synthases (PKSs), or other functional genes. Although genome sequencing has uncovered the differing qualities of these chemicals, recognizing new items and their biosynthetic pathways is still under examination. Cryptic metabolic pathways have been explored using molecular techniques or culture-dependent approaches. In recent years, researchers’ primary interest is to identify the specific conditions or agents that wake the cryptic antibiotics. Several bioinformatics and synthetic biology tools were developed to explore new antibiotics from actinobacteria. The book comprises 14 chapters with different aspects of application and utilization of actinomycetes from the microbiology; systems biology, pharmacology of natural products, bioinformatics, actinomycete and its diversity, CRISPR, artificial Intelligence, synthetic biology, metabolic engineering, expressional studies, and biosynthetic gene clusters. The book delivers useful information on actinomyces to researchers, novices in genome designing, specialists, clinicians, policymakers, and professionals.

Actinobacteria: Diversity and Biotechnological Applications: New and Future Developments in Microbial Biotechnology and Bioengineering, a volume in the series New and Future Developments in Microbial Biotechnology and Bioengineering series, offers the latest on the biotechnology of Kingdom actinobacteria, covering unique niches like their endosphere, rhizospheric soil and contaminated sites, etc. The book also covers the bioactive secondary metabolites obtained from actinobacteria and describes the application of microorganism (Actinobacteria) in plant growth promotion and in environmental cleanup. Finally, the book describes the biocontrol aspects of actinobacteria and how they can control fungal phytopathogens and the production of secondary metabolites. Includes an overview of all types of actinobacteria, source and enzymatic activity Lists various bioengineering methods for the production of these enzymes Reviews numerous industrial applications of actinobacteria, i.e., crop improvement, removal of heavy metals, etc. Offers unique coverage of the application of actinobacteria in bioremediation processes Explores the plant growth promoting potential of endophytic actinobacteria Describes biosynthetic potential genes associated with actinobacterial genome