Advances In Drug Therapy Of Gastroesophageal Reflux Disease

THE ESOPHAGUS The Esophagus investigates the anatomy, physiology, and pathology of the esophagus. This sixth edition, revised and updated throughout, also explores the diagnosis and treatment of various esophageal conditions. It includes treatment guidelines approved by the two largest gastroenterology societies, the ACG and AGA, as befits a work co-edited by two former presidents of those organizations. Advancements in diagnostics are presented, as are developments in the surgical and drug therapies. Presented in full colour, and boasting an unrivalled team of editors and contributing authors, The Esophagus Sixth Edition will find a home wherever the anatomy, physiology, and pathology of the esophagus are studied and taught. This book is accompanied by a website containing all the figures from the book in PowerPoint format. www.wiley.com/go/richter/esophagus6e Praise for the Fifth Edition: “There is absolutely no doubt that this edition of the textbook will maintain its status as the go-to reference for esophageal conditions, and will remain a highly utilized and clinically useful resource for novice and experienced physicians and surgeons alike.” (Gastroenterology, 1 July 2013)

First published in 2001. This book is an invaluable clinical reference for the therapeutic management of gastrointestinal and liver diseases which the gastroenterologist and trainee encounter in their practice. Various drugs and their interactions with their intended site and also with other drugs are discussed from a practical point of view. This book is not a treatise on gastrointestinal pharmacology but a practical guide to the therapeutic use of GI drugs.

In the past 30 years, gastroesophageal and reflux disease (GERD) has become an important area of clinical medicine. GERD has gradually become associated with other common but unexplained disorders. These conditions have been designated as the extraesophageal manifestations of GERD. Dr. Anthony J. DiMarino, Jr. and Dr. Sidney Cohen and their contributors have written Extraesophageal Manifestations of GERD with the purpose to identify associations with conditions like hoarseness, laryngeal cancer, sleep disorders, and dental caries, and to explore possible causation and mechanisms of disease or possible noncausal relationships. The extraesophageal disorders have become widely accepted in clinical practice. The evidence supporting the pathogenesis of these conditions falls into three major categories: guilt by association, observed mechanistic studies, and therapeutic response to treatment. Inside the pages of Extraesophageal Manifestations of GERD the reader will find recognition and balance in treating patients with common symptom-based disorders. Final resolution of some of the controversies inherent in these associations may require advanced diagnostic tools and advanced pharmacological therapies. With chapters written by experts in the fields of medicine, pediatrics, otolaryngology, and dentistry, Extraesophageal Manifestations of GERD will be a must have for gastroenterologists, internal medicine residents, surgeons, otolaryngologists, and pediatricians.

This book is the 5th in an exceptional series which, in a most uncommon way, constitutes an original encyclopaedia of esophagology. It is devoted to a single subject: the esophagogastric junction. These few centimetres are dissected into 420 questions which call on all the disciplines involved by its physiology, its diverse diseases and their various treatments. 450 answers, provided by the most renowned experts, each one shedding light on one small, but essential, fragment of the subject. The book offers: A succesion of syntheses; A profusion of targeted bibliographical references; An access, now made easy, to highly elaborated knowledge; A precious volume for researchers, specialists, departments heads, general practitioners and students.

The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.

With the dramatic increase of the aging population, the study and care of gastrointestinal disorders in the elderly have become priority topics for both clinicians and researchers. The geriatric approach which includes the epidemiology and pharmacokinetics of drugs as well as a comprehensive multidimensional assessment is particularly important in managing older patients with gastrointestinal disorders, since these patients are likely to have multiple interacting problems that interfere with their daily function and complicate their treatment. This book presents the results of recent studies in geriatric gastroenterology and reviews both basic and clinical aspects of the field. An important section is devoted to the close examination of the structural and functional effects of aging on the physiology of the gastrointestinal tract. Recent advances in diagnostic tools and the treatment of elderly patients with dysphagia and gastroesophageal reflux disease as well as with NSAID-related or Helicobacter pylori-associated gastroduodenal diseases are reported in updated chapters. The physician's approach to the management of disorders of the small intestine, colon, pancreas and liver is discussed, highlighting the specific aspects of such disorders in old age. As it is important that the geriatric assessment of elderly patients is carried out by a multidisciplinary team which includes experienced specialists as well as primary care physicians and community health workers, the book addresses a wide readership: general physicians, specialists in geriatrics and gastroenterology and health care providers involved in planning care for elderly patients with gastrointestinal disorders.