Aging And The Heart

In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.

Reviews the best therapies and surgical techniques available to provide quality care for the elderly cardiac patient and of those areas that require further research. The authors detail preventive therapies and the cardiovascular syndromes that disproportionately afflict the older individual, including arrhythmias (particularly atrial fibrillation), syncope, heart failure (particularly diastolic heart failure), and ischemic heart disease. They also delineate the surgical management of the heart patient with discussions of postoperative management and its complications and of specific surgical procedures such as coronary artery bypass grafting, valve surgery, pacemaker and defibibrillators, and surgical management of heart failure.

The population is aging, and most cardiovascular diseases are more common in older people. Older people often present atypically, have multiple co-morbidities, and are vulnerable to therapeutic delays or errors. The healthcare needs of the elderly differ from those of younger patients and are more complex, related to the physical and psychological changes associated with ageing and other disease processes in the elderly population. In addition, the response to treatment may alter with ageing, yet many elderly patients with cardiovascular disease are not looked after by specialists. Cardiovascular Disease in the Elderly provides user-friendly advice in a field that has limited evidence but contributes significantly to the workload not only of cardiologists but also of elderly care physicians and general practitioners. It reflects current UK and international guidelines and provides key evidence based references. Wherever possible, published guidelines are incorporated to ensure the book reflects current recommended management. It indicates where practice differs from that of younger adults, and provides guidance on the ethical and clinical dilemmas particular to the elderly. The handbook covers many aspects of cardiovascular disease in the elderly and focuses on common problems, including heart failure, atrial fibrillation and isolated systolic hypertension.

Discusses the advances made in learning how the normal aging process affects the heart & arteries & how to treat cardiovascular diseases. The most important findings are highlighted, & the future of cardiovascular medicine is also included. Chapters include: heat dynamics, measuring the heart, the biology of physical fitness, arteries: young & old, measuring stiffness, when the brain talks to the heart, how a myocyte contracts, exercise & the aging myocyte, what happens during atherosclerosis, & gene therapy. Glossary of terms. Illustrated.

This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations

A panel of clinicians, researchers, and leaders in the field review and discuss the latest findings on the pathophysiology, diagnosis, and management of cardiovascular disease in the older patient. The authors explain the physiological changes associated with the normal aging process that may lead to the development of disease, to adverse consequences once disease develops, and which alter the risk-benefit equation for medical and other interventions designed to diagnose, assess, and treat cardiovascular disease. The focus is on particularly common syndromes in the elderly, including cardiac failure with normal ejection fraction, isolated systolic hypertension, and atrial fibrillation. Wherever possible, the authors take an evidence-based approach to recommendations and rely heavily on prospective clinical trials.