Analyzing Medical Data Using S Plus

Each chapter consists of basic statistical theory, simple examples of S-PLUS code, plus more complex examples of S-PLUS code, and exercises. All data sets are taken from genuine medical investigations and will be available on a web site. The examples in the book contain extensive graphical analysis to highlight one of the prime features of S-PLUS. Written with few details of S-PLUS and less technical descriptions, the book concentrates solely on medical data sets, demonstrating the flexibility of S-PLUS and its huge advantages, particularly for applied medical statisticians.

Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".

Since the first edition of this book was published, S-PLUS has evolved markedly with new methods of analysis, new graphical procedures, and a convenient graphical user interface (GUI). Today, S-PLUS is the statistical software of choice for many applied researchers in disciplines ranging from finance to medicine. Combining the command line languag

This volume of the Biostatistics and Health Sciences Set focuses on statistics applied to clinical research. The use of SAS for data management and statistical modeling is illustrated using various examples. Many aspects of data processing and statistical analysis of cross-sectional and experimental medical data are covered, including regression models commonly found in medical statistics. This practical book is primarily intended for health researchers with a basic knowledge of statistical methodology. Assuming basic concepts, the authors focus on the practice of biostatistical methods essential to clinical research, epidemiology and analysis of biomedical data (including comparison of two groups, analysis of categorical data, ANOVA, linear and logistic regression, and survival analysis). The use of examples from clinical trials and epidemiological studies provide the basis for a series of practical exercises, which provide instruction and familiarize the reader with essential SAS commands. Presents the use of SAS software in the statistical approach for the management of data modeling Includes elements of the language and descriptive statistics Supplies measures of association, comparison of means, and proportions for two or more samples Explores linear and logistic regression Provides survival data analysis

Biostatistics and Computer-Based Analysis of Health Data Using the R Software addresses the concept that many of the actions performed by statistical software comes back to the handling, manipulation, or even transformation of digital data. It is therefore of primary importance to understand how statistical data is displayed and how it can be exploited by software such as R. In this book, the authors explore basic and variable commands, sample comparisons, analysis of variance, epidemiological studies, and censored data. With proposed applications and examples of commands following each chapter, this book allows readers to apply advanced statistical concepts to their own data and software. Features useful commands for describing a data table composed made up of quantitative and qualitative variables Includes measures of association encountered in epidemiological studies, odds ratio, relative risk, and prevalence Presents an analysis of censored data, the key main tests associated with the construction of a survival curve (log-rank test or Wilcoxon), and the Cox regression model

Statistical analysis is ubiquitous in modern medical research. Logistic regression, generalized linear models, random effects models, and Cox's regression all have become commonplace in the medical literature. But while statistical software such as SAS make routine application of these techniques possible, users who are not primarily statisticians must take care to correctly implement the various procedures and correctly interpret the output. Statistical Analysis of Medical Data Using SAS demonstrates how to use SAS to analyze medical data. Each chapter addresses a particular analysis method. The authors briefly describe each procedure, but focus on its SAS implementation and properly interpreting the output. The carefully designed presentation relegates the theoretical details to "Displays," so that the code and results can be explored without interruption. All of the code and data sets used in the book are available for download from either the SAS Web site or www.crcpress.com. Der and Everitt, authors of the best-selling Handbook of Statistical Analyses Using SAS, bring all of their considerable talent and experience to bear in this book. Step-by-step instructions, lucid explanations and clear examples combine to form an outstanding, self-contained guide--suitable for medical researchers and statisticians alike--to using SAS to analyze medical data.

This volume of the Biostatistics and Health Sciences Set focuses on statistics applied to clinical research. The use of Stata for data management and statistical modeling is illustrated using various examples. Many aspects of data processing and statistical analysis of cross-sectional and experimental medical data are covered, including regression models commonly found in medical statistics. This practical book is primarily intended for health researchers with basic knowledge of statistical methodology. Assuming basic concepts, the authors focus on the practice of biostatistical methods essential to clinical research, epidemiology and analysis of biomedical data (including comparison of two groups, analysis of categorical data, ANOVA, linear and logistic regression, and survival analysis). The use of examples from clinical trials and epideomological studies provide the basis for a series of practical exercises, which provide instruction and familiarize the reader with essential Stata packages and commands. Provides detailed examples of the use of Stata for common biostatistical tasks in medical research Features a work program structured around the four previous chapters and a series of practical exercises with commented corrections Includes an appendix to help the reader familiarize themselves with additional packages and commands Focuses on the practice of biostatistical methods that are essential to clinical research, epidemiology, and analysis of biomedical data