Applying Large Animals For Developmental Study And Disease Modeling
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Applying large animals for developmental study and disease modeling
Author | : Yongye Huang,Jacek Z. Kubiak,Lin Yuan,Sen Wu,Feng Yue |
Publsiher | : Frontiers Media SA |
Total Pages | : 155 |
Release | : 2023-06-21 |
Genre | : Science |
ISBN | : 9782832526880 |
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Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine
Author | : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use |
Publsiher | : National Academies Press |
Total Pages | : 139 |
Release | : 2018-05-29 |
Genre | : Science |
ISBN | : 9780309471190 |
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Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
Use of Laboratory Animals in Biomedical and Behavioral Research
Author | : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research |
Publsiher | : National Academies Press |
Total Pages | : 113 |
Release | : 1988-02-01 |
Genre | : Science |
ISBN | : 9780309038393 |
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Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
International Animal Research Regulations
Author | : National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders |
Publsiher | : National Academies Press |
Total Pages | : 102 |
Release | : 2012-06-26 |
Genre | : Science |
ISBN | : 9780309252119 |
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Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Author | : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research |
Publsiher | : National Academies Press |
Total Pages | : 223 |
Release | : 2003-08-22 |
Genre | : Science |
ISBN | : 9780309167857 |
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Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Animal Models for the Study of Human Disease
Author | : P. Michael Conn |
Publsiher | : Academic Press |
Total Pages | : 1108 |
Release | : 2013-05-29 |
Genre | : Science |
ISBN | : 9780124159129 |
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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
The Future of Animals Cells Models and Systems in Research Development Education and Testing
Author | : Anonim |
Publsiher | : National Academies |
Total Pages | : 364 |
Release | : 1977 |
Genre | : Science |
ISBN | : UOM:39015004349059 |
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Biomedical Models and Resources
Author | : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on New and Emerging Models in Biomedical and Behavioral Research |
Publsiher | : National Academies Press |
Total Pages | : 85 |
Release | : 1998-02-16 |
Genre | : Science |
ISBN | : 9780309060356 |
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