Bacteriocins And Other Ribosomally Synthesised And Post Translationally Modified Peptides Ripps As Alternatives To Antibiotics
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Bacteriocins and Other Ribosomally Synthesised and Post translationally Modified Peptides RiPPs as Alternatives to Antibiotics
Author | : Harsh Mathur,Paul David Cotter,Des Field,Mathew Upton |
Publsiher | : Frontiers Media SA |
Total Pages | : 177 |
Release | : 2021-08-17 |
Genre | : Science |
ISBN | : 9782889711116 |
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Prof Upton is the director of Amprologix, a company developing new bacteriocins; the other editors declare no competing interest in regard to editing this Research Topic.
Lasso Peptides
Author | : Yanyan Li,Séverine Zirah,Sylvie Rebuffat |
Publsiher | : Springer |
Total Pages | : 103 |
Release | : 2014-10-21 |
Genre | : Medical |
ISBN | : 9781493910106 |
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Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Nanocomposite and Nanohybrid Materials
Author | : Rajesh Kumar Verma,Devendra Kumar Singh,J. Paulo Davim |
Publsiher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 358 |
Release | : 2023-11-06 |
Genre | : Science |
ISBN | : 9783111137902 |
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The volume "Nanocomposite and Nanohybrid Materials: Processing and Applications" is an outstanding resource for exploring the findings and recent trends of nanocomposites and nanohybrid materials. Herein, a full grasp of cutting-edge research, new technologies, and exciting opportunities linked with nanocomposites and nanohybrids. Nanomaterials, including their synthesis, development, and advanced properties, are thoroughly investigated. Several processes for preparing nanomaterials are presented to the reader, along with their characteristics and development phase. It offers the latest applications of nanoparticles for diagnosing and treating neurological disorders and their use in biological imaging and targeted cancer treatments. This provides a strong basis for future study and innovation in this intriguing issue that is very important to methodology, qualitative approaches, and applications.
Prokaryotic Antimicrobial Peptides
Author | : Djamel Drider,Sylvie Rebuffat |
Publsiher | : Springer Science & Business Media |
Total Pages | : 451 |
Release | : 2011-03-08 |
Genre | : Science |
ISBN | : 9781441976925 |
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The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.
Radical SAM Enzymes
Author | : Anonim |
Publsiher | : Academic Press |
Total Pages | : 538 |
Release | : 2018-08-08 |
Genre | : Science |
ISBN | : 9780128127957 |
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Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Covers radical SAN enzymes in detail
Application of Protective Cultures and Bacteriocins for Food Biopreservation
Author | : Riadh Hammami,Ismail Fliss,Aldo Corsetti |
Publsiher | : Frontiers Media SA |
Total Pages | : 178 |
Release | : 2019-09-20 |
Genre | : Electronic Book |
ISBN | : 9782889630158 |
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The use of microorganisms and their metabolites for the preservation of foods began in prehistory. Lactic acid bacteria are generally recognized as safe (GRAS) for this purpose. They produce organic acids, diacetyl, acetoin, hydrogen peroxide, reuterin, reutericyclin and bacteriocins, all of which inhibit foodborne pathogens and spoilage microorganisms. Bacteriocins and the strains that produce them are particularly effective as bio-preservatives in cheese, meat and vegetables. They hold the promise of ensuring the quality and safety of ready-to-eat, extended-shelf-life, fresh-tasting and minimally processed foods without chemical preservatives. This Research Topic provides an overview of bacterial cultures, bacteriocins and other metabolites that have shown promise for use as antimicrobial bio-preservatives in foods in general. Articles describing novel analytical technologies, strategies to reduce or eliminate pathogens in food systems or emerging technologies for the production or use of protective cultures or their bacteriocins are presented.
Biomedical Research Medicine and Disease
Author | : RC Sobti,Aastha Sobti |
Publsiher | : CRC Press |
Total Pages | : 665 |
Release | : 2023-04-04 |
Genre | : Medical |
ISBN | : 9781000811193 |
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Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics. This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general. The volume comprehensively covers: Emerging technologies for health care Various aspects of biomedical research toward understanding of pathophysiology of the diseases Advances in improvement in diagnostic procedures and therapeutic tools The fundamental role of biomedical research in the development of new medicinal products
Marine Microbial Derived Molecules and Their Potential Medical and Cosmetic Applications
Author | : Jinwei Zhang,Antje Labes,Runying Zeng |
Publsiher | : Frontiers Media SA |
Total Pages | : 162 |
Release | : 2021-09-15 |
Genre | : Science |
ISBN | : 9782889713318 |
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