Basal Cell Carcinoma

​Basal Cell Carcinoma: Advances in Treatment and Research provides a comprehensive overview of evidence-based treatment approaches for the most common cancer worldwide - basal cell carcinoma. The first part of this book details the epidemiology, risk factors, pathophysiology, and different histologic subtypes of basal cell carcinoma highlighted with high-resolution histopathology images. The second part of the book provides an in-depth review of different treatment modalities including topical therapy, local immunotherapy with interferon, cryotherapy, electrodesiccation and curettage, radiotherapy, and surgical approaches with Mohs micrographic surgery, head and neck surgery, and oculoplastic surgery. The final part of book highlights the utilization of innovative technology such as photodynamic therapy and laser for the treatment of basal cell carcinoma while providing excellent cosmetic outcome as well as emerging systemic therapeutic options utilizing hedgehog pathway inhibitors and immunotherapy for the difficult-to-treat disease state, advanced basal cell carcinoma. Meant for a multi-disciplinary audience of dermatologists, Mohs Surgeons, oncologists, head and neck surgeons, oculoplastic surgeons, radiation oncologists, this book serves as an informative practical guide for physicians, mid-level providers and trainees.​ Basal Cell Carcinoma, is edited and written by leaders with expertise in cutaneous oncology, pathology, dermatology, Mohs micrographic surgery, plastic surgery, and many more specialties.

Mohs Micrographic Surgery, an advanced treatment procedure for skin cancer, offers the highest potential for recovery--even if the skin cancer has been previously treated. This procedure is a state-of-the-art treatment in which the physician serves as surgeon, pathologist, and reconstructive surgeon. It relies on the accuracy of a microscope to trace and ensure removal of skin cancer down to its roots. This procedure allows dermatologists trained in Mohs Surgery to see beyond the visible disease and to precisely identify and remove the entire tumor, leaving healthy tissue unharmed. This procedure is most often used in treating two of the most common forms of skin cancer: basal cell carcinoma and squamous cell carcinoma. The cure rate for Mohs Micrographic Surgery is the highest of all treatments for skin cancer--up to 99 percent even if other forms of treatment have failed. This procedure, the most exact and precise method of tumor removal, minimizes the chance of regrowth and lessens the potential for scarring or disfigurement

Non-melanoma skin cancer is a global public health issue. With an ever-increasing, and ageing, world population coupled with increasing numbers of immunosuppressed individuals the number of patients continues to rise. The head and neck is overwhelmingly the most frequent location for the development of a non-melanoma skin cancer and as such challenges the clinician with its complex anatomy. The importance of maintaining the aesthetics of the face and the function of the anatomy cannot be overstated, yet ultimately it is always the aim of curing a patient with the minimum of morbidity that clinicians strive for. However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g. involving metastatic lymph nodes or with perineural invasion present) and Merkel cell carcinomas.

The skin, uniquely positioned at the interface between the human body and the external world, plays a multifaceted role in the expression of cancer. Primary skin cancer is the most common cancer afflicting mankind and is rising in inci dence, despite the fact that it is often preventable. Besides primary cancer, the skin may show direct and indirect evidence of internal cancer, thus serving as a window to the body for both laymen and physicians alike. In addition, the acces sibility of the skin is useful for the study of carcinogenesis as well as cancer treat ment options. lowe much of my interest in skin cancer to Dr. Leon Goldman, the father of dermatologic laser surgery, and to Dr. Edmund Klein, the father of modern immunotherapy. We, at the Roswell Park Memorial Institute, were indeed for tunate to have a wealth of patients available for study. Many of the illustrations used in this book were of my patients at the Institute, and I kindly thank the fol lowing publications and their respective publishers for allowing me to reuse some of my photographs, most notably: Cancer Medicine (2nd edition), Journal of Surgical Oncology, Journal of the American Academy of Dermatology, Archives of Dermatology, Cancer, and Journal of Dermatologic Surgery and Oncology. We are very fortunate in this work to have some of the world's foremost authorities in their areas as contributors, such as Drs. Zackheim, Lambert, J.W. Trimble, J.R. Trimble, Jackson, Crutcher, Mashberg, Wick, Sidell, F. Helm, G.

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. Eduardo Calonje, Thomas Brenn, Alexander Lazar, and Phillip McKee present new illustrations, updated chapters, and coverage of new entities such as lymphomas, cutaneous tissue tumors, diseases of the nail, and more in this extensively revised fourth edition. This new edition is an absolute must for practicing dermatopathologists and general pathologists who sign out skin biopsies. It has over 5,000 images and new chapters on the pathology of HIV/AIDS, conjunctival tumors, sentinel lymph node biopsies, laboratory techniques in dermatopathology and a section on the pathology of salivary gland tumors. Also, the chapters on disorders of keratinization and diseases of the nails have been completely updated. With access to the full text, image and video bank online at www.expertconsult.com, you'll have convenient access to the guidance you need to formulate the most accurate reports. Recognize all the histological variations of any skin condition through coverage that integrates dermatopathology, clinical correlations, and clinical photographs. Easily reference key points thanks to bulleted lists of clinical features and differential diagnosis tables. Diagnose accurately using over 5,000 histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. Stay current with updated and expanded coverage of diseases of the nail, cutaneous connective tissue tumors, tumors of the lymphoreticular system, and conjunctiva specimens. Minimize errors and formulate accurate reports by applying up-to-date molecular research tools, classification guidelines, immunohistochemical practices, and more. Effectively correlate your findings with clinical features through all-new, high-quality illustrations—none repeated from the previous editions—for each diagnostic entity. Access the fully searchable text online at www.expertconsult.com, along with a downloadable image bank and a link to PathConsult.

Mohs surgery is microscopically controlled surgery used to treat common types of skin cancer and allows for the removal of a skin cancer with a very narrow surgical margin and a high cure rate. However, for those involved with the Mohs procedure, it is critical to understand the optimal preparation and interpretation of frozen sections. Complete with hundreds of high resolution figures, Atlas of Practical Mohs Histopathology is written by leading experts in the field and discusses everything from normal skin histology and rare tumors to pitfalls and incidental findings. Dermatologic surgeons, Mohs cutaneous surgeons, dermatopathologists and pathologists alike will find this book to be a comprehensive and indispensable reference.

This book provides a practical guide to the clinical decision-making process used in the management of skin cancers with the use of dermoscopy. Clinical cases are examined to help the reader through the treatment of unusual skin cancers using best practice techniques. A variety of skin conditions are covered, including melanoma, basal cell carcinoma, squamous cell carcinoma, Bowen’s disease and actinic keratosis. Clinical Cases in Dermoscopy of Skin Cancers highlights evidence-based best practice through its multidisciplinary approach and is an important addition to the literature to help trainees and practicing dermatologists or any healthcare professional who manages these patients.

This book provides a comprehensive, highly readable overview of our current knowledge of the molecular pathology of basal cell and squamous cell carcinomas. The chapters present the newest findings in epidemiology, photocarcinogenesis, genetics, immunology and molecular pathology of these epithelial skin tumours. The book will interest researchers or clinicians interested in the carcinogenesis and biology of basal cell or squamous cell carcinomas.