Basis And Treatment Of Cardiac Arrhythmias

This book incorporates the most up-to date information related to mechanisms and treatment of cardiac arrhythmia. Many of the topics discussed in this text reflect very recently undertaken research directions including genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These new approaches and implementations of anti-arrhythmic therapy derive from many decades of research as outlined in the first chapter by distinguished Professors Michael Rosen (Columbia University) and Michiel Janse (University of Amsterdam). The text covers changes in approaches to therapy over time, arrhythmias in multiple cardiac regions and over many scales, from gene to protein to cell to tissue to organ.

This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.​

This book is useful for physicians taking care of patients with cardiac arrhythmias and includes six chapters written by experts in their field. Chapter 1 discusses basic mechanisms of cardiac arrhythmias. Chapter 2 discusses the chronobiological aspects of the impact of apnoic episodes on ventricular arrhythmias. Chapter 3 discusses navigation, detection, and tracking during cardiac ablation interventions. Chapter 4 discusses epidemiology and pathophysiology of ventricular arrhythmias in several noncardiac diseases, methods used to assess arrhythmia risk, and their association with long-term outcomes. Chapter 5 discusses the treatment of ventricular arrhythmias including indications for implantation of an AICD for primary and for secondary prevention in patients with and without congestive heart failure. Chapter 6 discusses surgical management of atrial fibrillation.

This book provides up-to-date, user-friendly and comprehensive guidance on the evaluation, diagnosis, and medical and surgical treatment of cardiac arrhythmias. This ensures that that this title aids every trainee and practicising cardiologist, cardiac electrophysiologist, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients. Cardiovascular Medicine: Cardiac Arrhythmias, Pacing and Sudden Death covers every aspect of cardiac arrhythmias, from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventive cardiology. This coverage is presented with consistent chapter organization, clear design, and engaging text that includes user-friendly features such as tables, lists and treatment boxes.

A significantly expanded third edition, this book provides a comprehensive and concise overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. Additionally, the book emphasizes decision-making strategies in approaching each individual patient and the application of technical innovations in specific clinical situations. Organized into eight parts, beginning chapters introduce the concepts and principles of cardiac electrophysiology, unique rhythms, and ECG waves/signs. These chapters are designed to integrate emerging knowledge in basic science and clinical medicine. Subsequent chapters focus on the diagnosis of a variety of cardiac arrhythmias using non-invasive methodology. Throughout the book, chapters continue to analyze pharmacological and other approaches to therapy of specific arrhythmias, including supraventricular tachycardias, atrial fibrillation and flutter, ventricular arrhythmias, and bradyarrhythmias. Finally, the book closes with coverage on inherited cardiac arrhythmia syndromes including the long, short QT, and J-wave syndromes, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. The third edition of Management of Cardiac Arrhythmias, is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac surgery, vascular surgery, cardiac electrophysiology, and cardiac radiology.

This single-source reference/text is an authoritative, up-to-date, and multidisciplinary presentation of basic, applied, and clinical approaches to the diagnosis, treatment, and management of cardiac arrhythmia and the prevention of sudden cardiac death-providing essential concepts for new approaches to pharmacologic and electrical therapies. Over 50 leading physicians, scientists, and engineers integrate their research knowledge into a solid foundation of fundamentals in innovative new ways to promote an understanding of cardiac arrhythmias on a multilevel basis that spans the full range of topics from genes to therapy prevention. From the regular rhythm of the heart to the irregular, chaotic states that characterize fibrillation and tachyarrhythmias, Foundations of Cardiac Arrhythmias explores the ionic and molecular basis of electrogenesis and its control within different types of cardiac cells clarifies the molecular and biochemical regulation of cell-to-cell conduction that will help facilitate development of the next generation of antiarrhythmic drugs considers genetic determinants that influence the onset of sudden death in rare and acquired heart disease explores recent insights into macroscopic, three-dimensional interactions implicated in the genesis of malignant ventricular tachycardias surveys population studies that reveal new information about the relevance of higher frequency polymorphisms and variations in molecules involved in cardiac control discusses the role of cardiac ablation and the use of pacemakers and defibrillators, including new concepts in device design discusses promising new advances with noninvasive markers of arrhythmia risk that are helping to identify patients at risk for sudden death Containing nearly 2300 key literature citations and over 300 helpful drawings, photographs, equations, and tables, Foundations of Cardiac Arrhythmias serves as a thorough and inspiring reference for clinical and research cardiologists, clinical and basic electrophysiologists, pharmacologists, molecular and cell physiologists, biologists, biochemists, molecular geneticists, biomedical and electrical engineers, and biophysicists, as well as an important text for graduate students, residents, and fellows in these disciplines.