Bio Ceramics With Clinical Applications

Bioceramics have been used very successfully within the human body for many years. They are commonly used in orthopaedic surgery and dentistry but they are potentially suitable for a wide range of important applications within the medical device industry. This important book reviews the range of bioceramics, their properties and range of clinical uses.Chapters in the first section of the book discusses issues of significance to a range of bioceramics such as their structure, mechanical properties and biological interactions. The second part reviews the fabrication, microstructure and properties of specific bioceramics and glasses, concentrating on the most promising materials. These include alumina and zirconia ceramics, bioactive glasses and bioactive glass-ceramics, calcium sulphate, tricalcium phosphate-based ceramics, hydroxyapatite, tricalcium phosphate/hydroxyapatite biphasic ceramics, si-substrated hydroxyapatite, calcium phosphate cement, calcium phosphate coating, titania-based materials, ceramic-polymer composites, dental ceramics and dental glass-ceramics. The final group of chapters reviews the clinical applications of bioceramics in joint replacement, bone grafts, tissue engineering and dentistry.Bioceramics and their clinical applications is written by leading academics from around the world and it provides an authoritative review of this highly active area of research. This book is a useful resource for biomaterials scientists and engineers, as well as for clinicians and the academic community. Provides an authoritative review of this highly active area of research Discusses issues of significance of a range of bioceramics such as their structure, mechanical properties and biological interactions Reviews the clinical applications of bioceramics in joint replacement, bone grafts, tissue engineering and dentistry

This publication offers a unique approach that links the materials science of bioceramics to clinical needs and applications. Providing a structured account of this highly active area of research, the book reviews the clinical applications in bone tissue engineering, bone regeneration, joint replacement, drug-delivery systems and biomimetism, this book is an ideal resource for materials scientists and engineers, as well as for clinicians. From the contents: Part I Introduction 1. Bioceramics 2. Biomimetics Part II Materials 3. Calcium Phosphate Bioceramics 4. Silica-based Ceramics: Glasses 5. Silica-based Ceramics: Mesoporous Silica 6. Alumina, Zirconia, and Other Non-oxide Inert Bioceramics 7. Carbon-based Materials in Biomedicine Part III Material Shaping 8. Cements 9. Bioceramic Coatings for Medical Implants 10. Scaffold Designing Part IV Research on Future Ceramics 11. Bone Biology and Regeneration 12. Ceramics for Drug Delivery 13. Ceramics for Gene Transfection 14. Ceramic Nanoparticles for Cancer Treatment

This is the second edition of the classic book An Introduction to Bioceramics which provides a comprehensive overview of all types of ceramic and glass materials that are used in medicine and dentistry. The enormous growth of the field of bioceramics is due to the recognition by the medical and dental community of the importance of bioactive materials to stimulate repair and regeneration of tissues. This edition includes 21 new chapters that document the science and especially the clinical applications of the new generation of bioceramics in the field of tissue regeneration and repair. Important socioeconomic factors influencing the economics and availability of new medical treatments are covered with updates on regulatory procedures for new biomaterials, methods for technology transfer and ethical issues. The book contains 42 chapters that offer the only comprehensive treatment of the science, technology and clinical applications of all types of bioceramic materials used in medicine and dentistry. Each chapter is written by leaders in their specialized fields and is a thorough review of the subject matter, unlike many conference proceedings. All chapters have been edited to reflect the same writing style, making the book an easy read. The completeness of treatment of all types of bioceramics and their clinical applications makes the book unique in the field and invaluable to all readers.

Bioceramics and their Clinical Applications, Second Edition provides an update on our understanding of bioceramics, the wider range of ceramics available, and their more sophisticated processing technologies. This book is ideal for new entrants to the field who need to get up-to-speed on key scientific topics in this area and the wide range of ceramics that are available for key applications. This book will also serve as a key reference for experienced researchers on this topic because of its comprehensive approach to the topic. Reviews the most relevant bioceramics for bone regeneration, tooth and joint replacements, tissue engineering, cell therapy and disease treatment Includes new discussion on immune response and biological behavior of ceramics Reviews the latest processing technologies, such as 3D printing, sol-gel, powder metallurgy and coatings

Provides comprehensive coverage of the research into and clinical uses of bioceramics and biocomposites Developments related to bioceramics and biocomposites appear to be one the most dynamic areas in the field of biomaterials, with multiple applications in tissue engineering and medical devices. This book covers the basic science and engineering of bioceramics and biocomposites for applications in dentistry and orthopedics, as well as the state-of-the-art aspects of biofabrication techniques, tissue engineering, remodeling, and regeneration of bone tissue. It also provides insight into the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Featuring contributions from leading experts in the field, Bioceramics and Biocomposites: From Research to Use in Clinical Practice offers complete coverage of everything from extending the concept of hemopoietic and stromal niches, to the evolution of bioceramic-based scaffolds. It looks at perspectives on and trends in bioceramics in endodontics, and discusses the influence of newer biomaterials use on the structuring of the clinician’s attitude in dental practice or in orthopedic surgery. The book also covers such topics as biofabrication techniques for bioceramics and biocomposites; glass ceramics: calcium phosphate coatings; brain drug delivery bone substitutes; and much more. Presents the biggest trends in bioceramics and biocomposites relating to medical devices and tissue engineering products Systematically presents new information about bioceramics and biocomposites, developing diagnostics and improving treatments and their influence on the clinicians' approaches Describes how to use these biomaterials to create new functionalities when interfaced with biological molecules or structures Offers a range of applications in clinical practice, including bone tissue engineering, remodeling, and regeneration Delineates essential requirements for resorbable bioceramics Discusses clinical results obtained in dental and orthopedic applications Bioceramics and Biocomposites: From Research to Use in Clinical Practice is an excellent resource for biomaterials scientists and engineers, bioengineers, materials scientists, and engineers. It will also benefit mechanical engineers and biochemists who work with biomaterials scientists.

Provides comprehensive coverage of the research into and clinical uses of bioceramics and biocomposites Developments related to bioceramics and biocomposites appear to be one the most dynamic areas in the field of biomaterials, with multiple applications in tissue engineering and medical devices. This book covers the basic science and engineering of bioceramics and biocomposites for applications in dentistry and orthopedics, as well as the state-of-the-art aspects of biofabrication techniques, tissue engineering, remodeling, and regeneration of bone tissue. It also provides insight into the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Featuring contributions from leading experts in the field, Bioceramics and Biocomposites: From Research to Use in Clinical Practice offers complete coverage of everything from extending the concept of hemopoietic and stromal niches, to the evolution of bioceramic-based scaffolds. It looks at perspectives on and trends in bioceramics in endodontics, and discusses the influence of newer biomaterials use on the structuring of the clinician’s attitude in dental practice or in orthopedic surgery. The book also covers such topics as biofabrication techniques for bioceramics and biocomposites; glass ceramics: calcium phosphate coatings; brain drug delivery bone substitutes; and much more. Presents the biggest trends in bioceramics and biocomposites relating to medical devices and tissue engineering products Systematically presents new information about bioceramics and biocomposites, developing diagnostics and improving treatments and their influence on the clinicians' approaches Describes how to use these biomaterials to create new functionalities when interfaced with biological molecules or structures Offers a range of applications in clinical practice, including bone tissue engineering, remodeling, and regeneration Delineates essential requirements for resorbable bioceramics Discusses clinical results obtained in dental and orthopedic applications Bioceramics and Biocomposites: From Research to Use in Clinical Practice is an excellent resource for biomaterials scientists and engineers, bioengineers, materials scientists, and engineers. It will also benefit mechanical engineers and biochemists who work with biomaterials scientists.

The topics covered in this volume include: biomedical applications; fabrication processes; structural, physical and biological analyses; and clinical applications of ceramics. In addition, the book presents discussions on recent bioceramic technologies for the development of ceramics with tissue-bonding properties. Recent advances in the development of joint replacements using ceramics are also discussed. The book will prove to be invaluable for materials scientists, bioengineers, molecular and cellular biologists, bone biologists, and clinicians. Contents:Orthopedics:Treatment of Osteomyelitis by Using Antibiotic-Loaded Porous Ceramic (M Itokazu et al.)Hydroxyapatite Tricalcium Phosphate as a Filler for Infected Bone Defects (K Suzuki et al.)Dental, ENT and Craniofacial Applications:New Aspects of the Degradation of Porcelain in Dentistry (A M Gatti et al.)Histological Evaluation for Removed HA-Coated Implants (H Oguchi et al.)Ceramics for Joints:New Knee Prosthesis with Bisurface Femoral Component Made of Alumina Ceramic — Its Concept and Clinical Performance (T Nakamura et al.)Development of an Advanced Ceramic/Titanium Alloy Knee Joint (M G S Murray et al.)Biological Apatite Formation In Vitro:Enhanced Bioactivity of Poled Strontium Hydroxyapatite Ceramics (Y Seki et al.)The Mechanism of Apatite Formation on Na2O-SiO2 Glass in Simulated Body Fluid (H Takadama et al.)Bonding Strength of Apatite Layer Formed on Chemically-Treated Tantalum Metal (T Miyazaki et al.)Cell Culture on Bioceramics:Vectorial Effects on Selective Cell Adhesion of Electrically Poled Hydroxyapatite Ceramics (M Ohgaki et al.)Enhanced In Vitro Cell Activity and Surface Apatite Layer Formation on Novel Silicon-Substituted Hydroxyapatites (I R Gibson et al.)Cell/Tissue Engineering and Bone Biology:Role of Cbfal in Osteoblast and Chondrocyte Differentiation (T Komori)Histo-Pathological Study of Bone Formation Using Porous Hydroxyapatite-BMP Composite in Dog Jaw Bone Defect (N Nagai et al.)Tissue Response to Bioceramics:Resorption of Calcium Phosphate Ceramics of Different Crystal Size (U Gross et al.)Comparative Bone Growth Behavior Inter-Spaces of Granules of Bioglass, A W Glass Ceramics and Hydroxyapatite (H Oonishi et al.)Calcium Phosphate Ceramics:Hot Press Production and Mechanical Properties of Synthesized Carbonate Hydroxyapatite of Gel Monolithic Origin (E G Nordstrom et al.)Biocompatibility of Co3Apatite Preparations with Solubility Gradients (M Okazaki et al.)Glass and Glass Ceramics:Analysis of the Kinetics of Dissolution and the Evolution of the Mechanical Properties of a Phosphate Glass Stored in Simulated Body Fluid (J Clément et al.)Composites:The Biomimetic Synthesis and Biocompatibility of Self-Organized Hydroxyapatite/Collagen Composites (M Kikuchi et al.)Hydrostatically Extruded Hydroxyapatite Reinforced Polyethylene as a Load-Bearing Bone Substitute (M Wang et al.)Coating:Mechanical Testing of Electrophoretically Deposited Hydroxyapatite (M Wei et al.)Biological Evaluation and Surface Properties of Bonelike Hydroxyapatite Thin Films Prepared by RF-Sputtering Method (S Nakamura et al.)Bioactive Bone Cements:Effects of Surface Curing Properties on Bone-bonding Strength of Bioactive Bone Cement (S Shinzato et al.)Special Preparations and Drug Delivery System:Synthesis of Blood Compatible Ceramic Powders and New Methods of Examining Anti Clotting Properties (S Takashima et al.)Singapore Workshop:Cartilage Induced by a Natural Bioceramic (NACRE) Implanted in the Knees of Sheep (E Lopez et al.)and other papers Readership: Orthopaedic surgeons, materials scientists, pathologists, ENT surgeons and biologists. Keywords:Biomedical;Fabrication;Ceramics;Tissue-Bonding;Filler;Dental;Bone Defects;Degradation;Implants;Prosthesis;Bioglass;Biomimetic;Orthopaedic