Biochemical Engineering Fundamentals

Biochemical Engineering Fundamentals, 2/e, combines contemporary engineering science with relevant biological concepts in a comprehensive introduction to biochemical engineering. The biological background provided enables students to comprehend the major problems in biochemical engineering and formulate effective solutions.

The goal of this textbook is to provide first-year engineering students with a firm grounding in the fundamentals of chemical and bioprocess engineering. However, instead of being a general overview of the two topics, Fundamentals of Chemical and Bioprocess Engineering will identify and focus on specific areas in which attaining a solid competency is desired. This strategy is the direct result of studies showing that broad-based courses at the freshman level often leave students grappling with a lot of material, which results in a low rate of retention. Specifically, strong emphasis will be placed on the topic of material balances, with the intent that students exiting a course based upon this textbook will be significantly higher on Bloom’s Taxonomy (knowledge, comprehension, application, analysis and synthesis, evaluation, creation) relating to material balances. In addition, this book also provides students with a highly developed ability to analyze problems from the material balances perspective, which leaves them with important skills for the future. The textbook consists of numerous exercises and their solutions. Problems are classified by their level of difficulty. Each chapter has references and selected web pages to vividly illustrate each example. In addition, to engage students and increase their comprehension and rate of retention, many examples involve real-world situations.

The biology, biotechnology, chemistry, pharmacy and chemical engineering students at various universtiy and engineering institutions are required to take the Biochemical Engineering course either as an elective or compulsory subject. This book is written keeping in mind the need for a text book on afore subject for students from both engineering and biology backgrounds. The main feature of this book is that it contains the solved problems, which help the students to understand the subject better. The book is divided into three sections: Enzyme mediated bioprocess, whole cell mediated bioprocess and the engineering principle in bioprocess. Dr. Rajiv Dutta is Professor in Biotechnology and Director, Amity Institute of Biotechnology, Lucknow. He earned his M. Tech. in Biotechnology and Engineering from the Department of Chemical Engineering, IIT, Kharagpur and Ph.D. in Bioelectronics from BITS, Pilani. He has taught Biochemical Engineering and Biophysics to B.E., M.E. and M.Sc. level student carried out advanced research in the area of Ion channels at the Department of Botany at Oklahoma State University, Stillwater and Department of Biological Sciences at Purdue University, West Lafayette, IN. He also holds the position of Nanion Technologies Adjunct Research Professor at Research Triangle Institute, RTP, NC. He had received various awards including JCI Outstanding Young Person of India and ISBEM Dr. Ramesh Gulrajani Memorial Award 2006 for outstanding research in electro physiology.

A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given. With contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.

This text is intended to provide students with a solid grounding in basic principles of biochemical engineering. Beginning with a historical review and essential concepts of biochemical engineering in part I, the next three parts are devoted to a comprehensive discussion of various topics in the areas of life sciences, kinetics of biological reactions and engineering principles. Having described the different building blocks of life, microbes, metabolism and bioenergetics, the book proceeds to explain enzymatic kinetics and kinetics of cell growth and product formation. The engineering principles cover transport phenomena in bioprocess systems and various bioreactors, downstream processing and environmental technology. Finally, the book concludes with an introduction to recombinant DNA technology. This textbook is designed for B.Tech. courses in biotechnology, B.Tech. courses in chemical engineering and other allied disciplines, and M.Sc. courses in biotechnology.

Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering.