Biology Of The Laboratory Mouse

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse.

"Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse"--Provided by publisher.

The Laboratory Mouse / Joan Staats -- Breeding Systems / Earl L. Green -- Keeping Records / Margaret M. Dickie -- Husbandry / Edwin P. Les -- Nutrition / Warren G. Hoag and Margaret M. Dickie -- Nomenclature / Joan Staats -- Nuclear Cytology / Allen B. Griffen -- Mutant Genes and Linkages / Margaret C. Green -- Multiple Factor Inheritance / Thomas H. Roderick and Gunther Schlager -- Radiation Genetics / Earl L. Green and Thomas H. Roderick -- Reproduction / Franklin H. Bronson, Charles P. Dagg, and George D. Snell -- Early Embryology / George D. Snell and Leroy C. Stevens -- Anatomy / Katharine P. Hummel, Flavia L. Richardson, and Elizabeth Fekete -- Teratogenesis / Charles P. Dagg -- Genes and Development / Margaret C. Green -- Physiological Characteristics / Seldon E. Bernstein -- Blood and Blood Formation / Elizabeth S. Russell and Seldon E. Bernstein -- Blood Coagulation / Hans Meier and Warren G. Hoag -- Inherited Metabolic Variations / Andrew A. Kandutsch and Douglas L. Coleman -- Endocrine Variations / Chen K. Chai and Margaret M. Dickie -- Pigmentation / H. Glenn Wolfe and Douglas L. Coleman -- Acute Responses to Ionizing Radiation / John B. Storer -- Responses to Drugs / Hans Meier and John L. Fuller -- Genetics of Tissue Transplantation / George D. Snell and Jack H. Stimpfling -- Cell, Tissue, and Organ Culture / Charity Waymouth -- Lifespan and Aging Patterns / Elizabeth S. Russell -- Characteristic Tumors / Edwin D. Murphy -- Transplanted Tumors / Nathan Kaliss -- Constitutional Diseases / Elizabeth S. Russell and Hans Meier -- Infectious Diseases / Warren G. Hoag and Hans Meier -- Immune Functions / Henry J. Winn -- Neural, Sensory and Motor Functions / John L. Fuller and Richard E. Wimer -- Patterns of Behavior / Richard E. Wimer and John L. Fuller.