Biomaterials Science

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. Provides comprehensive coverage of principles and applications of all classes of biomaterials Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites Endorsed by the Society for Biomaterials

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters

Biomaterials Science and Technology: Fundamentals and Developments presents a broad scope of the field of biomaterials science and technology, focusing on theory, advances, and applications. It reviews the fabrication and properties of different classes of biomaterials such as bioinert, bioactive, and bioresorbable, in addition to biocompatibility. It further details traditional and recent techniques and methods that are utilized to characterize major properties of biomaterials. The book also discusses modifications of biomaterials in order to tailor properties and thus accommodate different applications in the biomedical engineering fields and summarizes nanotechnology approaches to biomaterials. This book targets students in advanced undergraduate and graduate levels in majors related to fields of Chemical Engineering, Materials Engineering and Science, Biomedical Engineering, Bioengineering, and Life Sciences. It assists in understanding major concepts of fabrication, modification, and possible applications of different classes of biomaterials. It is also intended for professionals who are interested in recent advances in the emerging field of biomaterials.

Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines-physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations. Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the reader. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and serves as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.

This book is written for those who would like to advance their knowledge beyond an introductory level of biomaterials or materials science and engineering. This requires one to understand more fully the science of materials, which is, of course, the foundation of biomaterials. The subject matter of this book may be divided into three parts: (1) fundamental structure-property relationships of man-made materials (Chapters 2-5) and natural biological materials, including biocompatibility (Chapters 6 and 7); (2) metallic, ceramic, and polymeric implant materials (Chapters 8-10); and (3) actual prostheses (Chapters 11 and 12). This manuscript was initially organized at Clemson University as classnotes for an introductory graduate course on biomaterials. Since then it has been revised and corrected many times based on experience with graduate students at Clemson and at Tulane University, where I taught for two years, 1981-1983, before joining the University of Iowa. I would like to thank the many people who helped me to finish this book; my son Y oon Ho, who typed all of the manuscript into the Apple Pie word processor; my former graduate students, M. Ackley Loony, W. Barb, D. N. Bingham, D. R. Clarke, J. P. Davies, M. F. DeMane, B. J. Kelly, K. W. Markgraf, N. N. Salman, W. J. Whatley, and S. o. Young; and my colleagues, Drs. W. Cooke, D. D. Moyle (Clemson G. H. Kenner (University of Utah), F. University), W. C. Van Buskirk (Tulane University), and Y.

At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.

"This book is essential when designing, developing and studying biomedical materials.... provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. ... This well presented book strongly insists on how the materials can influence patients’ needs, the ultimate drive for biomedical engineering. ...[presents an] Interesting and innovative review from a patient focus perspective—the book emphasizes the importance of the patients, which is not often covered in other biomedical material’s books." —Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, England Going far beyond the coverage in most standard books on the subject, Biomaterials Science: An Integrated Clinical and Engineering Approach offers a solid overview of the use of biomaterials in medical devices, drug delivery, and tissue engineering. Combining discussion of materials science and engineering perspectives with clinical aspects, this book emphasizes integration of clinical and engineering approaches. In particular, it explores various applications of biomaterials in fields including tissue engineering, neurosurgery, hemocompatibility, BioMEMS, nanoparticle-based drug delivery, dental implants, and obstetrics/gynecology. The book engages those engineers and physicians who are applying biomaterials at various levels to: Increase the rate of successful deployment of biomaterials in humans Lower the side-effects of such a deployment in humans Accumulate knowledge and experience for improving current methodologies Incorporate information and understanding relevant to future challenges, such as permanent artificial organ transplants Using a variety of contributors from both the clinical and engineering sides of the fields mentioned above, this book stands apart by emphasizing a need for the often lacking approach that integrates these two equally important aspects.

Adopting an interdisciplinary approach to the chemistry and physics of materials, their biocompatibility, and the consequences of implantation of such devices into the human body, this text introduces readers to the principles of polymer science and the study of metals, ceramics and composites, and also to the basic biology required to understand the nature of the host-transplant interface. Topics covered include the macromolecular components of cells and tissues, self-assembly processes, biological cascade systems, microscopic structure of cells and tissues, immunology, transplantation biology, and the pathobiology of wound healing. The materials science section includes the structures and properties of polymers, metals, ceramics and composites, and the processes for forming materials as well as the pathobiology of devices. The final two chapters deal with tissue engineering and the relations between the biology of cells and tissue transplantation, and the engineering of tissue replacements using passaged cells.