Bone Adaptation

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.

This book relates the mechanical and structural properties of bone to its function in man and other vertebrates. John Currey, one of the pioneers of modern bone research, reviews existing information in the field and particularly emphasizes the correlation of the structure of bone with its various uses. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

A comprehensive analysis of changes in body form and skeletal robusticity from the Terminal Pleistocene through the Holocene, leading to the modern European human phenotype. Skeletal Variation and Adaptation in Europeans: Upper Paleolithic to the Twentieth Century brings together for the first time the results of an unprecedented large-scale investigation of European skeletal remains. The study was conducted over ten years by an international research team, and includes more than 2,000 skeletons spanning most of the European continent over the past 30,000 years, from the Early Upper Paleolithic to the 20th century. This time span includes environmental transitions from foraging to food production, small-scale to large-scale urban settlements, increasing social stratification and mechanization of labor, and climatic changes. Alterations in body form and behavior in response to these transitions are reconstructed through osteometric and biomechanical analyses. Divided into four sections, the book includes an introduction to the project and comprehensive descriptions of the methods used; general continent-wide syntheses of major trends in body size, shape, and skeletal robusticity; detailed regional analyses; and a summary of results. It also offers a full data set on an external website. Brings together data from an unprecedented large-scale study of human skeletal and anatomical variations Includes appendix of specific information from each research site Synthesizes data from spatial, temporal, regional, and geographical perspectives Skeletal Variation and Adaptation in Europeans will be a valuable resource for bioarchaeologists, palaeoanthropologists, forensic anthropologists, medical historians, and archaeologists at both the graduate and post-graduate level.

In steel-tipped prose, Craig Davidson conjures up a bleak world populated by hardscrabble pugilists, fighting dogs, sex addicts, and others held captive by their own bad luck and bad decisions. Visceral and with a dark urgency, Rust and Bone is a strikingly original debut.

See the Grishaverse come to life on screen with the Netflix series, Shadow and Bone -- Season 2 streaming now! Meet Kaz Brekker and his crew: Jesper, Inej, Wylan, and the star-crossed Nina and Matthias, on the heist of a lifetime in Six of Crows from #1 bestselling author, Leigh Bardugo. Ketterdam: a bustling hub of international trade where anything can be had for the right price—and no one knows that better than criminal prodigy Kaz Brekker. Kaz is offered a chance at a deadly heist that could make him rich beyond his wildest dreams. But he can't pull it off alone. . . . A convict with a thirst for revenge. A sharpshooter who can't walk away from a wager. A runaway with a privileged past. A spy known as the Wraith. A Heartrender using her magic to survive the slums. A thief with a gift for unlikely escapes. Six dangerous outcasts. One impossible heist. Kaz's crew is the only thing that might stand between the world and destruction—if they don't kill each other first. Six of Crows by Leigh Bardugo returns to the breathtaking world of the Grishaverse in this unforgettable tale about the opportunity—and the adventure—of a lifetime. Read all the books in the Grishaverse! The Shadow and Bone Trilogy (previously published as The Grisha Trilogy) Shadow and Bone Siege and Storm Ruin and Rising The Six of Crows Duology Six of Crows Crooked Kingdom The King of Scars Duology King of Scars Rule of Wolves The Language of Thorns: Midnight Tales and Dangerous Magic The Severed Moon: A Year-Long Journal of Magic The Lives of Saints