Brief Review

Get heard by being clear and concise The only way to survive in business today is to be a lean communicator. Busy executives expect you to respect and manage their time more effectively than ever. You need to do the groundwork to make your message tight and to the point. The average professional receives 304 emails per week and checks their smartphones 36 times an hour and 38 hours a week. This inattention has spread to every part of life. The average attention span has shrunk from 12 seconds in 2000 to eight in 2012. So, throw them a lifeline and be brief. Author Joe McCormack tackles the challenges of inattention, interruptions, and impatience that every professional faces. His proven B.R.I.E.F. approach, which stands for Background, Relevance, Information, Ending, and Follow up, helps simplify and clarify complex communication. BRIEF will help you summarize lengthy information, tell a short story, harness the power of infographics and videos, and turn monologue presentations into controlled conversations. Details the B.R.I.E.F. approach to distilling your message into a brief presentation Written by the founder and CEO of Sheffield Marketing Partners, which specializes in message and narrative development, who is also a recognized expert in Narrative Mapping, a technique that helps clients achieve a clearer and more concise message Long story short: BRIEF will help you gain the muscle you need to eliminate wasteful words and stand out from the rest. Be better. Be brief.

Harvard’s acclaimed geologist “charts Earth’s history in accessible style” (AP) “A sublime chronicle of our planet." –Booklist, STARRED review How well do you know the ground beneath your feet? Odds are, where you’re standing was once cooking under a roiling sea of lava, crushed by a towering sheet of ice, rocked by a nearby meteor strike, or perhaps choked by poison gases, drowned beneath ocean, perched atop a mountain range, or roamed by fearsome monsters. Probably most or even all of the above. The story of our home planet and the organisms spread across its surface is far more spectacular than any Hollywood blockbuster, filled with enough plot twists to rival a bestselling thriller. But only recently have we begun to piece together the whole mystery into a coherent narrative. Drawing on his decades of field research and up-to-the-minute understanding of the latest science, renowned geologist Andrew H. Knoll delivers a rigorous yet accessible biography of Earth, charting our home planet's epic 4.6 billion-year story. Placing twenty first-century climate change in deep context, A Brief History of Earth is an indispensable look at where we’ve been and where we’re going. Features original illustrations depicting Earth history and nearly 50 figures (maps, tables, photographs, graphs).

For more than eighty years the Jewish Daily Forward's legendary advice column, "A Bintel Brief" ("a bundle of letters") dispensed shrewd, practical, and fair-minded advice to its readers. Created in 1906 to help bewildered Eastern European immigrants learn about their new country, the column also gave them a forum for seeking advice and support in the face of problems ranging from wrenching spiritual dilemmas to petty family squabbles to the sometimes hilarious predicaments that result when Old World meets New. Isaac Metzker's beloved selection of these letters and responses has become for today's readers a remarkable oral record not only of the varied problems of Jewish immigrant life in America but also of the catastrophic events of the first half of our century. Foreword and Notes by Harry Golden

An eminent psychologist offers a major new theory of human cognition: movement, not language, is the foundation of thought When we try to think about how we think, we can't help but think of words. Indeed, some have called language the stuff of thought. But pictures are remembered far better than words, and describing faces, scenes, and events defies words. Anytime you take a shortcut or play chess or basketball or rearrange your furniture in your mind, you've done something remarkable: abstract thinking without words. In Mind in Motion, psychologist Barbara Tversky shows that spatial cognition isn't just a peripheral aspect of thought, but its very foundation, enabling us to draw meaning from our bodies and their actions in the world. Our actions in real space get turned into mental actions on thought, often spouting spontaneously from our bodies as gestures. Spatial thinking underlies creating and using maps, assembling furniture, devising football strategies, designing airports, understanding the flow of people, traffic, water, and ideas. Spatial thinking even underlies the structure and meaning of language: why we say we push ideas forward or tear them apart, why we're feeling up or have grown far apart. Like Thinking, Fast and Slow before it, Mind in Motion gives us a new way to think about how--and where--thinking takes place.

Brookner again shows herself to be the consummate observer of social nuance in this deeply felt chronicle of an unlikely friendship between the flamboyant, ego-centric Julia and modest, self-effacing Fay, the narrator. Thrust together by their husbands' business partnership and by their sharing of a guilty secret, these two women form an intense and intimate bond that highlights their uneasy compromises with each other -- and with life itself.

Shares a personal story about pain and loss, as Monica Wesolowska gives birth to a healthy-seeming baby boy until the doctors give her son a grim prognosis. The story that follows is not a story of typical maternal heroism. There is no medical miracle here. Instead, we find the strangest of hopes. Certain of her choice, Monica must still ask herself at every step if she is loving Silvan as well as a mother can. The result is a page-turning testimony to the power of love.

A beautiful meditation on the joys of being a grandparent and a practical guide to help you and your adult children make the most of your relationship with a grandchild. For many grandparents, a grandchild offers a second chance to become the parent they didn’t have the time or the energy to be when raising their own children. Being a grandparent, family relationships expert Jane Isay argues, is the opportunity to turn missed opportunities into delight. Drawing on her personal experience, dozens of interviews, and the latest findings in psychology, Isay shows how a grandparent can use his or her unique perspective and experience to create a deep and lasting bond that will echo throughout a grandchild’s life. She explores the realities of today’s multigenerational families, identifying problems and offering solutions to enhance love, trust, and understanding between grandparents, parents, and grandchildren. She also offers a wealth of practical advice, from when to get involved, when to stay away, and how to foster a strong relationship when you’re separated by long distance. Unconditional Love advocates for honest conversation, thinking in the long run and healing breaches in order to be together, understanding that most of us try to do our best and need to be forgiven if we fail. Isay argues that secrets and surprises may tilt the boat but won’t necessarily sink it and that grandparents and their grown children are happier when they give each other the benefit of the doubt. Most importantly, she writes, the advent of grandchildren offers families the opportunity for healing and redemption—if we seize the moment. In lovely prose and through delightful stories, Isay shows us how we can. A great gift for grandparents-to-be and a wonderful resource for all, Unconditional Love is a beautiful and psychologically astute look at what it means to be an engaged grandparent.

Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: Stopping or slowing the growth of cancer cells Stopping cancer from spreading to other parts of the body Helping the immune system work better at destroying cancer cells There are several types of immunotherapy, including: Monoclonal antibodies and tumor-agnostic therapies Non-specific immunotherapies Oncolytic virus therapy T-cell therapy Cancer vaccines Part II- “What is Chimeric Antigen Receptor (CAR) T- Cell Therapy?” An Emerging Cancer Treatment Modality. Chimeric antigen receptor (CAR) T-cell therapy is an emerging cancer treatment modality in which the patients’ own immune cells are collected, genetically engineered to recognize a tumor-related target, expanded in vitro, and then reinfused to produce responses and prevent progression in a variety of malignancies (ie, adoptive cell transfer) Several types of adoptive cell transfer(ACT) are under investigation, but CAR T-cell therapy is the first to enter clinical practice. Like other technologies, CAR-T cell therapy has undergone a long development process in the past. Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. I have endeavored to compile this E- Booklet into Two Parts i.e. Part I & Part II for better understanding of Chimeric antigen receptor (CAR) T-cell therapy, an emerging cancer treatment modality. In Part I, an effort has been made to describe Cancer Immunotherapy briefly whereas in Part II know about of CAR T-Cell Therapy-the first to enter clinical practice- has been embodied. Further it is attempted to describe toxicity of CAR-T cell therapy briefly and future development and opportunities for immunotherapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)