Cardiac Repolarization

A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.

The past decade has seen an explosion of knowledge and radical changes in our understanding of ventricular repolarization as an integral part of the cardiac electrophysiologic matrix. Cardiac Repolarization: Bridging Basic and Clinical Science comprehensively reviews all the latest developments in cardiac electrophysiology, focusing on both clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions, among them early repolarization and short QT interval, Brugada syndrome, long QT syndrome, and sudden infant death syndrome. Chapters delineate objectives and key points, and include established and evidence-based knowledge, current perspectives, areas of controversy, and recommendations for future investigations. Comprehensive and clinically oriented, Cardiac Repolarization: Bridging Basic and Clinical Science surveys the major research discoveries that have recently transformed our understanding of cardiac electrophysiology and spells out in full detail their clinical implications for the diagnosis and treatment of patients with malignant electrical instability of the heart.

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Recent research cited above has documented that QRS/T angle and other novel repolarization measures of deviant repolarization are potent predictors of cardiac morbidity and mortality over and above the traditional risk factors such as old ECG-MI, ECG-LVH or QT prolongation. A novel ECG model of repolarization based on electrophysiological considerations developed by the author has been the cornerstone in this search for improved predictors. The concepts involved in these quantitative methods are advanced and clinicians may not readily understand their utility in patient care. Their value is perhaps more easily comprehended by investigators who are collaborating in preventive studies and evaluation of adverse effects of cardio-active agents. It is expected that this book will facilitate understanding how these new ECG finding can be used in both clinical and epidemiological application.​

Until recently, the cellular basis for sudden death, the BrugadaSyndrome, has largely remained an unknown to modernarrhythmologists and cardiologists, particularly in the absence ofany structural heart disease. Detailed observations of age-groups,especially the young, families and populations where sudden deathfrequently occurs, and improved understanding of its contributoryfactors and mechanisms are, however, showing the way forward. This addition to the Clinical Approaches to Tachyarrhythmias(CATA) Series, written by the investigators who discovered andprobed the Brugada Syndrome, discusses the history, etiology,pathology and clinical manifestations of sudden death. Fromdiagnosis, prognosis, to therapeutic approaches using the latest incathater ablation techniques, electrophysiological surgery, andgenetic appraisal, the work is a testimony to the author'sinvestigation. Using clinical cases in Thailand and Laos, theyfurther unravel the syndrome's molecular mechanisms, studyingrelated syndromes, such as the long-QT syndrome, infant death, andarryhthmogenic right ventricular cardiomyopathy. By being informed of the electrophysiological abnormalities thatcontribute to familial and genetic diseases, physicians,cardiologists and all those who care for patients with cardiacarrhythmias will be better able to identify and treat patients inwhom the Brugada Syndrome may strike next.

A convenient guide of easily accessible information on the mechanisms of myocardial repolarization and related clinical issues. This book provides a unique collection of contributions by prominent cardiologists on the current knowledge of the mechanisms of arrhythmias, the molecular and genetic bases of noninvasive electrocardiologic diagnosis, and other related clinical issues. In addition to mechanistic aspects, recent developments in the diagnosis of arrhythmias using newly recognized markers (QT dispersion, T-wave alternans, etc.) and their clinical importance are addressed in an easily accessible manner by world-renowned authors. The book is a quick-reference for practicing cardiologists and electrophysiologists, those in training, and others who work in the field of arrhythmology.