Cell Tissue Injury And Cytoprotection Organoprotection In The Gastrointestinal Tract

Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.

The capsaicin, a component of paprika, has been used in the culinary practice of every day nutritional practice. This agent is known to cause a variety of actions in the body through activating capsaicin-sensitive afferent neurons. A recently launched book entitled, Capsaicin-Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside, is attractive for several reasons. First, Prof. Mozsik, a chief editor of this book, is known internationally as an expert in capsaicin pharmacology. Since he has worked for many years as a head of internal medicine, taking care of patients with various GI diseases, he is able to make a correct interpretation of various findings obtained in basic researches to clinical events. Second, although there are many articles about capsaicin, they mostly deal with basic research and finding but do not include much about clinical finding. Third, this book encompassed review articles written by internationally accepted scientists leading the field of capsaicin research, who highlighted the current state of knowledge on pharmacology, physiology and clinical phathophysiology of capsaicin-sensitive afferent neurons, and discussed directions for future research. Overall, this book is for people who are interested in the capsaicin action in body.

Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.

The book on Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection deals with various aspects of peptic ulcer disease, like clinical pharmacology, nutrition, molecular biochemical pharmacology as well as clinical aspects, and especially with the evaluation of certain biochemical mechanisms in human gastric mucosa and in animal gastric tissues obtained from different ulcer models. This book can be useful to physiologists; biochemists; pharmacologists, particularly molecular and biochemical pharmacologists; internists; gastroenterologists; biologists; surgeons and pharmacists.

This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases. Contents:General Introduction to Inflammation and Cancer in the Digestive Tract (Ming Xing Li and Chi Hin Cho)Inflammation and Therapeutics in the Digestive Tract:Brain–Gut Relationship on Mucosal Inflammation in the Gastrointestinal Tract (Klara Gyires and Ágnes Fehér)Nesfatin-1: The Novel Appetite Peptide with Therapeutic Efficacy to Prevent Acute Hemorrhagic Gastric Lesions and Accelerate Gastric Ulcer Healing (Aleksandra Szlachcic, Jolanta Majka, and Tomasz Brzozowski)Chemoprophylaxis in Inflammatory Bowel Disease (Nikola Mitrev, Aladdin Alswaifi, and Rupert W Leong)Targeting the Nuclear Receptor HNF4α as a Potential Therapy for Gut Inflammation and Cancer (Jean-Philippe Babeu and François Boudreau)Established Therapies and New Therapeutic Strategies in Alcoholic Liver Disease (Helmut Karl Seitz and Sebastian Mueller)Carcinogenesis and Therapeutic Targets in the Gastrointestinal Tract:Targets of Tumor Epigenetics and Its Microenvironment in Gastrointestinal Cancer (Ssu-Yin Yen, Hong-Meng Chuang, Mao-Hsuan Huang, Sheng-Feng Tsai, Tzyy-Wen Chiou, Hong-Lin Su, Li-Ing Ho, Shinn-Zong Lin, and Horng-Jyh Harn)Esophageal Cancer: From Bench to Bedside (Gang Ma and Zhihua Liu)Angiogenesis and Lymphangiogenesis in Gastric MALT Lymphoma: Relation of VEGF and VASH2 (Masahiko Nakamura, Anders Øverby, and Hidenori Matsui)NF-κB as a Potential Molecular Target for Therapy of Gastrointestinal Cancers (Nathan Palmer, Muthu K Shanmugam, Gautam Sethi, and Philipp Kaldis)Hypoxia-Inducible Factor-1κ Modulation in Colorectal Carcinogenesis (Francesco Mariani, Stefano Mancini, Paola Sena, and Luca Roncucci)Therapeutic Approaches Targeting the Serrated Pathway of Colorectal Cancer Characterized by Mutation in the BRAF Gene and Overexpression of GTPase Rac1b (Paulo Matos, Vânia Gonçalves, and Peter Jordan)The "Yin" and "Yang" of Target-Oriented Anticancer Phytochemicals Derived from Herbal Medicines (Kathy K Auyeung and Joshua K S Ko)The Degradation System of Prostaglandin E2 in Gastrointestinal Cancer (Tetsuya Tanigawa, Toshio Watanabe, Shogo Takeda, Hiroshi Tatsuwaki, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, and Tetsuo Arakawa)Prostaglandin and Its Receptors: Potential Targets for Gastrointestinal Inflammation and Cancer (Vivian Y Shin and Ava Kwong)Autophagy and microRNAs as the Therapeutic Targets in Gastrointestinal Cancers:Modulation of Autophagy as a Potential Therapeutic Target for Gastrointestinal Cancers: Promises and Uncertainties (Li Ma)microRNAs as Therapeutic Targets for Gastric Cancer (Takatsugu Ishimoto and Hideo Baba)microRNA-based Novel Therapeutic Development in Gastrointestinal Cancer (Andrew Fesler and Jingfang Ju)Unraveling the Relationship between Autophagy and microRNA in Gastrointestinal Cancer (Yuanyuan Yin, Peiqi Wang, Yaxin Zheng, Yi Chen, and Jinhui Wang) Readership: Basic and clinical researchers in the fields of inflammation, hepatology, pathology, pharmacology, oncology and gastroenterology. Can be used as a reference for their research and clinical practice in academic and industrial sectors.

The clinical problems and dilemmas which the busy clinician encounters on a daily basis are the main focus of this publication. Emphasizing a clinical rather than a pathophysiological approach to problems, it facilitates access and helps the practicing clinician to develop an effective and efficient diagnostic and therapeutic strategy. Nevertheless, clinically important aspects of pathophysiology are also dealt with in detail when called for. A variety of scenarios that are especially relevant to modern medical practice, such as the intensive care unit, are taken into account. A group of internationally renowned experts guides the reader through the broad variety of diagnostic options available to assist in the assessment of symptoms originating anywhere along the gastrointestinal tract, from the esophagus to the anus, and, in each instance, every effort is made to critically appraise the technology discussed. Moreover, general overviews of broadly relevant therapeutic approaches are also provided.

The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.

Indocyanine green (ICG) fluorescence has been used for imaging purposes for more than half a century; First employed by ophthalmologists for visualizing the retinal artery in the late 1960s, the application of ICG fluorescence imaging has since been continuously expanded. Recently, advances in imaging technologies have led to renewed attention regarding the use of ICG in the field of hepatobiliary surgery, as a new tool for visualizing the biliary tree and liver tumors.