Chemistry Biology And Medicine Of Neurohypophyseal Hormones And Their Analogs

Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The book discusses the anatomy, physiology, and clinical disorders of the neurohypophysis; the biosynthesis of neurohypophyseal peptides; and the structure-activity relationships of neurohypophyseal peptides, with an emphasis on the role of conformational features. The text also describes conformational studies of neurohypophyseal hormones by physical chemical techniques; the central nervous system effects of neurohypophyseal peptides; and the effects of neurohypophyseal hormones on the kidney. The effects of neurohypophyseal hormones on the cardiovascular systems are also considered. Chemists, neurobiologists, and people involved in the study of neurohypophyseal hormones will find the book invaluable.

Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The book discusses the anatomy, physiology, and clinical disorders of the neurohypophysis; the biosynthesis of neurohypophyseal peptides; and the structure-activity relationships of neurohypophyseal peptides, with an emphasis on the role of conformational features. The text also describes conformational studies of neurohypophyseal hormones by physical chemical techniques; the central nervous system effects of neurohypop ...

The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry but also with important and useful aspects of design, analysis, handling, and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well as the latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Its contents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.

Vasopressin and oxytocin are the key hormones of the hypothalamo-neurohypophysial system, and are well-known to be critically involved in antidiuresis, labor, and milk ejection. This book highlights the latest research on vasopressin and oxytocin, covering multiple biological aspects. The capacity of both hormones to regulate various aspects of social behaviours including pair-bonding, aggression, maternal love, and sexual behaviour, is a main focus, as are their interactions with a variety of other neuromodulators and transmitters. Moreover, the book illustrates the recent development of vasopressin and oxytocin agonists/antagonists as potential drugs to treat not only disturbances of body fluid homeostasis, but also mental disorders, including social phobia, autism, anxiety, and depression. The promising combination of basic and clinical research, comprising physiology, neuroendocrinology, behavioral biology, pharmacology, imaging and molecular genetics makes this book an essential addition to both experts and scientists new to the field alike. • Comprehensive review of OXT and AVP physiology and behaviour • Each chapter covers a novel aspect of OXT and AVP research and is written by a leading expert • Review articles are ideal for experts and newcomers to the field alike • Discusses fascinating behavioural effects of oxytocin and vasopressin • Summarizes the recent explosion of neuropeptide research, physiology and behaviour, is in one location

The Industry-University Cooperative Chemistry Program has sponsored seven previous international symposia covering a wide variety of topics of interest to industrial and academic chemists. The eighth IUCCP symposium, held March 19-22, 1990, at Texas A&M University, represents a deviation from the former symposia, in that it is the first of a two-symposium series dedicated to the rapidly moving new field of industrial biochemistry that has beco~e known as biotechnology. Biotechnology is really not a new discipline, but rather is a term coined to describe the new and exciting commercial applications of biochemistry. The development of the field of biotechnology is a direct result of recombinant DNA technology, which began in earnest about 15 years ago. Today, we can routinely do experiments that were inconceivable in the early 1970's. Only comparatively simple technology available even in small laboratories is required to synthesize a gene and from it, to produce vast amounts of biological materials of enormous commercial value. These technical developments and others have stimulated increased activities in the field of enzyme biotechnology, using enzymes to catalyze "unnatural" reactions to produce complex molecules with stereochemical precision. It is true today, we can readily produce DNA fragments that will encode any amino acid sequence that we might desire, but at this point, our foundation of basic knowledge falls short. The dream of "designer enzymes" is still a fantasy, but the current wave of research activity and exciting new developments suggest that in the future the dream may become a reality.

First multi-year cumulation covers six years: 1965-70.

Now, in one volume, the latest research from the areas of molcular biology, neurochemistry and behavior analysis of drug abuse and dependence, with, wherever possible, an integration of the data from these various levels of analysis. The ensuing reports point to the complexity of the phenomenon of abuse and dependence and clearly demonstrate that it is determined by a variety of variables from molecular biology and genetics through behavioral history. This complexity is shown, however, to be responsive to rigorous scientific analysis and our success to date gives rise to hope that this distressing public health problem can ultimately be brought under control. Each of the chapters is written by a leading researcher in the field.