Clinical Studies On Nutraceuticals And Dietary Supplements

The book, Clinical Studies in Nutraceuticals and Dietary Supplements, presents extensive information on all the vital aspects and evidence-based studies on nutraceuticals and dietary supplements. The most fascinating part of this book is that the chapters explore the key concept accompanying an emphasis on recent research and developments on nutraceuticals and dietary supplements to tackle various diseases including maternal and fetal health, cancer, cardiovascular, renal disorders, hepatic disorders, hormonal disorders, and neurological dysfunction. The introspection carries updated literature reviews with relevant vital topics, quality illustrations, and well-organized tables for a better understanding of each segment. The current market scenario of these nutraceuticals and dietary supplements is the emphasis on their importance for a healthy and disease-controlled environment. This book will be useful to research scholars and scientists, as well as individuals working in the nutraceutical, dietary supplement, and functional food industries. This is an initiative to unveil the immense wealth that these nutraceuticals and dietary supplements hold and a realization of the fact that more evidence-based studies are required for its use to curb maladies and foster a healthy lifestyle.

In the last three decades, revolutionary achievements have taken place in nutraceutical and functional food research including the introduction of a number of cutting-edge dietary supplements supported by human clinical trials and strong patents. Novel manufacturing technologies including unique extraction processes, bioavailability improvements through delivery technologies such as nanotechnology, and innovative packaging have been critical steps for their successful positioning in the marketplace and consumer acceptance worldwide. Nonetheless, mixed messages have emerged from both the scientific community and the media concerning the potential benefits of foods and nutrients in the treatment and prevention of disease. This confusion, in addition to existing marketed products making questionable health claims, have led health practitioners and consumers to become skeptical about nutritional claims of new and emerging food products. Clinical Aspects of Functional Foods and Nutraceuticals provides an extensive overview of the clinical aspects of functional foods and nutraceuticals. It contains information on both nutritional challenges and potential health benefits of functional foods and nutraceuticals. In addition to exploring the underpinning science, the book also focuses on food innovation, functional foods in human health, food–drug interactions, functional foods in medicine, the seed-to-clinic approach, global regulatory frameworks, challenges, and future directions. The book provides an essential overview of the clinical aspects surrounding functional foods and nutraceuticals for key stakeholders, drawing links between areas of knowledge that are often isolated from each other. This form of knowledge integration will be essential for practice, especially for policy makers and administrators.

Over half of the adult population in the U.S. includes some sort of dietary supplement in their diet. This book provides the reader with a better understanding of the science and quality issues of dietary supplements. It explains terms regarding supplements, regulatory implications and standards of botanical extracts, and provides background on the supplement industry and pharmacoeconomics of supplements. It also identifies the health benefits and risks.

Although health claims for nutraceuticals range from the fantastic to the sublime, most of these claims are based on cell culture studies and have not been validated in humans, making them inadequate for public health recommendations. Focusing on human population-based research (epidemiology studies), Nutraceuticals and Health: Review of Human Evidence explores the role of nutraceuticals in human health, disease prevention, health promotion, and as an adjunct to disease treatment. The editors and their team of recognized experts deliver a comprehensive scientific review of the latest research. The book opens with a general background of nutraceuticals and human health, then covers health and disease areas such as cancer, lipidermia and cardiovascular disease, metabolic syndrome with obesity, diabetes and hypertension, respiratory health, the gut microbiome, and cognitive decline. It then concludes by addressing the methodological issues that must be addressed in the conduct of epidemiological research on nutraceuticals in health and disease. Although nutraceuticals hold significant promise in alleviating the suffering from disease, for this potential to be fulfilled, much more research is needed to document safety and disease risks in humans. Addressing important knowledge gaps, the book includes cutting-edge summaries that highlight both the biological and epidemiological findings of relevant studies of nutraceuticals in health and disease. Taking an unusual, yet crucial epidemiological focus, it examines whether, and what kinds of, evidence exist to support a role for nutraceuticals in disease risk, prevention, and treatment.

This handbook provides key information on the clinical use of nutraceuticals, an increasingly common practice grounded in an understanding of the pharmacological activities of natural compounds and clinical evidence of efficacy and safety. Each chapter examines the effects of nutraceuticals in different therapeutic contexts, including nutraceuticals active on the digestive system, heart, lipid and glucose metabolism, and immune system. The authors also address relevant concerns such as relative and absolute contraindications, range of tested doses (efficacious and safe), possible side effects and pharmacological interactions, and the scientific level of clinical evidence for each product. Despite the availability of a large number of nutraceuticals on the market, the same compound is often offered by different industries at different dosages and concentrations, with different titration and often with different suggestions of efficacy. Available academic books on nutraceuticals prioritize summarizing information or focus on the pharmacological aspects on cells or animals models rather than on proof in humans. The handbook takes a unique and practical approach intended to assist clinicians, pharmacologists, nutritionists, and dietitians considering prescribing nutraceuticals for therapeutic use. Renowned expert Professor Arrigo Cicero is known internationally for his work in nutraceuticals, and currently serves as President of the Italian Nutraceutical Society.

As soon as Dr. Stephen DeFelice coined the phrase nutraceutical, product and supplement developers swung into action. Yet among the numerous books available on nutraceuticals, there is none that systematically lists, categorizes, and analyzes nutraceutical extracts and formulations in a pharmacopoeia-like manner. Handbook of Nutraceuticals, Volume 1: Ingredients, Formulations, and Applications lists information on many ingredients used in nutraceuticals, developing their formulations and applications. The book includes contributions from experts with pharmaceutical backgrounds, providing an examination of nutraceuticals from a pharmaceutical perspective. Building a foundation with coverage of historical background, definitions, and challenges, the book offers insight into nutraceutical ingredients from plant, animal, and mineral origin. It then covers the characterization of nutraceuticals’ physicochemical, analytical, pharmacological, and pharmacokinetic classification, followed by information on regulatory requirements. The book highlights applications in cardiovascular disease, bone and joint treatments, diabetes management, weight management, skin health, probiotics and prebiotics, tranquilizing medicinal plants, dietary foods, and more. Interest in new diet regimens and new products for increased health and longevity will continue to grow, giving dietary supplements an increasing amount of cupboard space in most households. With quality of content unsurpassed by many resources, the book discusses the characterization processes for nutraceuticals based on the contributors’ experience in pharmaceuticals. It then explores how those proven techniques may be applied to the development and manufacture of nutraceutical products.

Nutrients, Dietary Supplements, and Nutriceuticals: Cost Analysis Versus Clinical Benefits provides the most current, concise, scientific appraisal and economic analysis (costs vs. benefit) of nutritional supplements and bioactive components (nutriceuticals) of foods in improving the quality of life. It fills a much-needed gap to have a single volume provide a synopsis of cost analysis of dietary supplements and nutritional products as well as therapies for treatment and prevention of disease. Chapters include emerging fields of science and important discoveries relating to early stages of new nutriceuticals in cancer prevention, prior to clinical trials. Written by international and national standing leaders in the field, Nutrients, Dietary Supplements, and Nutriceuticals: Cost Analysis Versus Clinical Benefits is essential reading for nutritionists, pharmacologists, health care professionals, research scientists, cancer workers, pathologists, molecular and cellular biochemists, physicians, general practitioners as well as those interested in diet and nutrition in disease resistance via immune regulation.

Dietary supplements made from foods, herbs and their constituents are a rapidly growing market sector. Consumers often view food supplements as ‘natural’ and therefore safe; however, supplements are regulated as foods rather than as pharmaceuticals and so are not as closely monitored as may be necessary. With the commercial market in these products growing, this book provides essential research into their safety, efficacy and potential risk of interaction with pharmaceuticals. Following an introductory chapter, part one covers the chemical composition, manufacture and regulation of dietary supplements. Part two looks at the effectiveness of different types of dietary supplement and methods of evaluation. Finally, part three focuses on supplement safety. Reviews the design, production and regulation of dietary supplements. Analyses the potential for pharmacokinetic and pharmacodynamics interactions between dietary supplements and pharmaceuticals. Offers reviews of important clinical studies on the efficacy of dietary supplements for range of conditions.