Cognitive Psychological And Psychiatric Consequences Of The Coronavirus Covid 19 Pandemic In The Population Of Older Persons With Cognitive Impairment Dementia And Or Neuropsychiatric Disorders

The physical effects of COVID-19 are felt globally. However, one issue that has not been sufficiently addressed is the impact of COVID-19 on mental health. During the COVID-19 pandemic, citizens worldwide are enduring widespread lockdowns; children are out of school; and millions have lost their jobs, which has caused anxiety, depression, insomnia, and distress. Mental Health Effects of COVID-19 provides a comprehensive analysis of mental health problems resulting from COVID-19, including depression, suicidal thoughts and attempts, trauma, and PTSD. The book includes chapters detailing the impact of COVID-19 on the family’s well-being and society dynamics. The book concludes with an explanation on how meditation and online treatment methods can be used to combat the effects on mental health. Discusses family dynamics, domestic violence, and aggression due to COVID-19 Details the psychological impact of COVID-19 on children and adolescents Includes key information on depression, anxiety, and suicide as a result of COVID-19

Social isolation is generally recognized as a major public health problem and is widely recognized to have detrimental consequences for people's health, including reduced mental health, increased risk of disease (e.g., hypertension, cardiovascular disease, cancer), mortality, and cognitive decline. It is widely recognized that social isolation is a major cause of death. Combined with the recent COVID-19 and other changes in social conditions, social isolation, and loneliness are becoming an increasing concern. Social isolation can occur regardless of gender or age, and the occurrence process and related factors warrant further investigation.

Olfactory dysfunction, also known as anosmia and hyposmia, is one of the most prevalent (80-90%) symptoms reported by patients with COVID-19. Outside the context of COVID-19, chemosensory dysfunction has been associated with decreased quality of life, anxiety, depression, and cognitive impairment. In the setting of COVID-19, decreased sense of smell has been positively associated with mood disorders such as anxiety and depression. The short-term and long-term neuropsychiatric implications of the olfactory dysfunction related to COVID-19 are still largely unexplored. Investigation of the neuropsychiatric sequelae of olfactory dysfunction related to COVID-19 infection is particularly critical to characterize the pathological effects of COVID-19 on brain function and to develop strategies to improve patient’s quality of life and mental wellbeing. In this Research Topic, Frontiers aims to highlight studies that investigate the neuropsychiatric, psychological, and cognitive consequences of COVID-19-related olfactory dysfunction, present current advances in the field, and anticipate health care needs for the development of therapeutic interventions.

The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.