Handbook of Combinatorial Chemistry

Handbook of Combinatorial Chemistry
Author: K. C. Nicolaou,Rudolf Hanko,Wolfgang Hartwig
Publsiher: Wiley-VCH
Total Pages: 652
Release: 2002-04-29
Genre: Medical
ISBN: UOM:39015051613373

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In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.

Combinatorial Chemistry

Combinatorial Chemistry
Author: Nicholas K. Terrett
Publsiher: Unknown
Total Pages: 204
Release: 1998
Genre: Combinatorial chemistry
ISBN: 0198502192

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Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.

Combinatorial Chemistry

Combinatorial Chemistry
Author: Stephen R. Wilson,Anthony W. Czarnik
Publsiher: John Wiley & Sons
Total Pages: 288
Release: 1997-03-28
Genre: Medical
ISBN: 047112687X

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The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Combinatorial Synthesis of Natural Product Based Libraries

Combinatorial Synthesis of Natural Product Based Libraries
Author: Armen M. Boldi
Publsiher: CRC Press
Total Pages: 363
Release: 2006-05-16
Genre: Science
ISBN: 9781420009279

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Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Combinatorial Chemistry

Combinatorial Chemistry
Author: Günther Jung
Publsiher: John Wiley & Sons
Total Pages: 634
Release: 2008-07-11
Genre: Science
ISBN: 9783527613519

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The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.

Combinatorial Chemistry

Combinatorial Chemistry
Author: John Abelson
Publsiher: Elsevier
Total Pages: 546
Release: 1996
Genre: Combinatorial chemistry
ISBN: 0121821684

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features* Phage display libraries* Repression fusion proteins* Polysome libraries* Peptide libraries* Nucleic acid libraries* Other small molecule libraries.

Combinatorial Chemistry and Technologies

Combinatorial Chemistry and Technologies
Author: Stanislav Miertus,Giorgio Fassina
Publsiher: CRC Press
Total Pages: 597
Release: 2005-04-12
Genre: Medical
ISBN: 9781420027846

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Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the

Combinatorial Chemistry and Technology

Combinatorial Chemistry and Technology
Author: Stanislav Miertus,Giorgio Fassina
Publsiher: CRC Press
Total Pages: 456
Release: 1999-07-01
Genre: Science
ISBN: 142000056X

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"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."