Commercial And Pre Commercial Cell Detection Technologies For Defence Against Bioterror

As a response to the rapidly emerging threat of bioterrorism, the objectives of this volume on Commercial and Pre-Commercial Cell Detection Technologies for Defence against Bioterror are to exchange information on commercially available technologies and equipment for defense against bioterrorism; to further the development of new biosensor system prototypes into a commercially available apparatus and to explore human factors in BWA biosensors. The new commercial and pre-commercial technologies that are currently emerging in the world are presented and explained. Furthermore, there is a discussion about the interaction of modern detection systems with society and a trial for improvement of the relation between the scientific community and commercial entities. There are four major areas highlighted: the first is a presentation of the most advanced biosensors and biodetection system which can be found in the market or are quite close to commercialization. Systems as the BIOHAWKTM, SASS 2000, RAPTOR, Bionas® 2500, OWLS, or a portable SPR are presented in this section. The second issue is a presentation of the advances in the research of biodetection devices as DNA and protein microchips, micro and nanophotonic sensors, CMOS microsensor chips, electrochemical arrays, physical platforms, electro optical detection, mass detection, etc. Then, there is a description of the latest developments in the employment of bioreceptor layers for the selective detection of BWA, as protein signatures, molecular imprinted polymers, membrane engineering (MIME), cell signatures, monoclonal antibodies, synthetic antibodies and lytic phages, among others. The last part is the discussion of the human factor: societal issues related to sensor development and employment for BWA detection.

As a response to the rapidly emerging threat of bioterrorism, this volume aims to exchange information on commercially available technologies and equipment for defense against bioterrorism; to further the development of new biosensor system prototypes into a commercially available apparatus and to explore human factors in BWA biosensors.

This is a critical assessment of breakthrough biosensor technologies that will allow for the rapid identification of biological threat agents in the environment and human population. The book provides a comprehensive overview of the current state of biological weapons threat, and reviews biosensor technologies including detection platforms, networked alarm-type biodetector systems, implementation strategies, electro-optical and electrochemical biosensors.

This is a critical assessment of breakthrough biosensor technologies that will allow for the rapid identification of biological threat agents in the environment and human population. The book provides a comprehensive overview of the current state of biological weapons threat, and reviews biosensor technologies including detection platforms, networked alarm-type biodetector systems, implementation strategies, electro-optical and electrochemical biosensors.

A biosensor is defined as a detecting device that combines a transducer with a biologically sensitive and selective component. When a specific target molecule interacts with the biological component, a signal is produced, at transducer level, proportional to the concentration of the substance. Therefore biosensors can measure compounds present in the environment, chemical processes, food and human body at low cost if compared with traditional analytical techniques. Bringing together researchers from 11 different countries, this book covers a wide range of aspects and issues related to biosensor technology, such as biosensor applications in the fields of drug discovery, diagnostics and bacteria detection, optical biosensors, biotelemetry and algorithms applied to biosensing.

Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications Includes contributions from leading international researchers with extensive experience in developing medical biosensors Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care

This book provides detailed information on the surface and surface chemistry of various biointerfaces for the understanding and development of biosensors, biocompatible devices, and drug delivery systems. It highlights the role of interfacial phenomena towards the behaviour of biomolecules on different surfaces and their significance in recent applications. The book also addresses various surface engineering techniques for the modification of biomaterials that are implemented for improving biocompatibility. It provides an updated scientific concept of various interactions of biological systems with surfaces/modified surfaces at the molecular and cellular level. The chapters include various in-vitro, in-vivo, ex-vivo models to illustrate various aspects of Biointerface Engineering. Finally, the book elucidates troubleshooting strategies and future prospects of Biointerface Engineering in Medical Diagnostics and Drug Delivery.

Molecular imprinting focuses on the fabrication of an artificial receptor with perfect molecular recognition abilities. It has attracted a great deal of scientific attention because of the enormous opportunities it opens in the fields of separation, catalysis, and analysis. The advantages of the molecular imprinting enable to target a wide class of substances ranging from small molecules to big conglomerates, such as proteins or even cells. In recent years, sensor applications based on molecular imprinting have started to attract greater attention because of the easy creation of robust receptor sites with high specificity and sensitivity toward a target compound. A collection of contributions from distinguised experts, Handbook of Molecular Imprinting: Advanced Sensor Applications provides a comprehensive overview on the specific challenges of molecular imprinting in sensor applications. It covers various molecular imprinting approaches. As a result, a perspective of future device ensembles for sensing is acquired. The text lays particular emphasis on fundamental aspects as well as novel ideas in the context of sensor applications. It also highlights the operation principles of various sensor transducers that are generally employed in combination with molecular imprinting recognition elements.