Controlled Release Systems

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

In the area of controlled release of active substances, such as drugs, a strong interest in nanoparticles as carriers of active ingredients has arisen. Some of the active components are extremely hydrophobic, without cellular permeability and susceptible to metabolic degradation. Owing to this, their use is limited. This kind of agent can be transported without any problem through physiological media by using nanoparticles. The size of particles is an important parameter because it governs the efficiency of the delivery system. For this type of application, particles that have a diameter smaller than 1 μm are especially useful. Polymeric nanoparticles that have diameters in the colloidal range are produced by means of polymerization processes in dispersed media. Drugs are taken up into the nanoparticles by adsorption, absorption, or “entrapment," or covalent bonding and they are delivered (release) by desorption, diffusion, polymer degradation, or a combination of these mechanisms. Nanoparticles (including nanogels) that release their contents by external triggering open up new possibilities for therapeutic strategies. External triggering by light, heat, change in pH, or application of ultrasound opens up the possibility to release the material on demand. If only a part of the wall of the nanoparticle (nanocapsule) is responsive, we are dealing with the so-called nanobottles, a nanocontainer with the active substance and a lid on the container that can be "opened" and "closed" by external triggering. This book focuses on responsive nanoparticles and brings together two interesting areas: nanoparticles and responsive polymers. The concept of the book is that of a systematic approach from nanoparticles synthesis via responsive polymers to nanobottles. The second part of the book presents contributions from experts in the field and provides a state-of-the-art overview of the field.

The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications

The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules!

This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.