Cytochrome Oxidase In Neuronal Metabolism And Alzheimer S Disease
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Cytochrome Oxidase in Neuronal Metabolism and Alzheimer s Disease
Author | : Francisco Gonzalez-Lima |
Publsiher | : Springer Science & Business Media |
Total Pages | : 294 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 9781475799361 |
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This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.
Oxidative energy Metabolism in Neurodegenerative Disorders
Author | : John P. Blass,Fletcher H. McDowell |
Publsiher | : Unknown |
Total Pages | : 472 |
Release | : 1999 |
Genre | : Medical |
ISBN | : UVA:X004419543 |
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There is solid evidence of abnormalities in oxidative / energy metabolism with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The papers contained in this book are an attempt to move studies in this area to a deeper, more mechanistic level.
Metabolism in Alzheimer s Disease
Author | : Heather M. Wilkins,Levi Wood,Jill K. Morris |
Publsiher | : Frontiers Media SA |
Total Pages | : 183 |
Release | : 2022-02-11 |
Genre | : Science |
ISBN | : 9782889743612 |
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Cytochrome Oxidase
Author | : Mårten Wikström,Klaas Krab,Matti Saraste |
Publsiher | : Unknown |
Total Pages | : 216 |
Release | : 1981 |
Genre | : Science |
ISBN | : MINN:31951000007691P |
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Mitochondrial Dysfunction
Author | : Lawrence H. Lash,Dean P. Jones |
Publsiher | : Elsevier |
Total Pages | : 528 |
Release | : 2013-10-22 |
Genre | : Science |
ISBN | : 9781483218618 |
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Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Brain Aging
Author | : David R. Riddle |
Publsiher | : CRC Press |
Total Pages | : 408 |
Release | : 2007-04-19 |
Genre | : Medical |
ISBN | : 1420005529 |
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Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Brain Glycogen Metabolism
Author | : Mauro DiNuzzo,Arne Schousboe |
Publsiher | : Springer Nature |
Total Pages | : 443 |
Release | : 2019-10-31 |
Genre | : Medical |
ISBN | : 9783030274801 |
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This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.
Mitochondrial Oxidative Phosphorylation
Author | : Bernhard Kadenbach |
Publsiher | : Springer Science & Business Media |
Total Pages | : 378 |
Release | : 2012-06-23 |
Genre | : Medical |
ISBN | : 9781461435730 |
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This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.