Diagnostic Pathology Familial Cancer Syndromes

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Physicians should have the knowledge derived from morphological findings to identify the likelihood of a cancer patient having an additional underlying familial syndrome- and to decide if that patient should undergo molecular genetic evaluation. This volume is specifically designed to help pathologists, oncologists, and other physicians who diagnose and treat cancer to recognize syndromes and syndrome- associated neoplasms and advise patients and their families on the possibility of a familial syndrome and their risk of developing other tumors. Diagnostic Pathology: Familial Cancer Syndromes, second edition, is an easy-to-use, one-stop reference for information on hereditary cancer syndromes, including differential diagnosis and management, that offers a templated, highly formatted design; concise, bulleted text; and superior color images throughout.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Physicians should have the knowledge derived from morphological findings to identify the likelihood of a cancer patient having an additional underlying familial syndrome— and to decide if that patient should undergo molecular genetic evaluation. This volume is specifically designed to help pathologists, oncologists, and other physicians who diagnose and treat cancer to recognize syndromes and syndrome- associated neoplasms and advise patients and their families on the possibility of a familial syndrome and their risk of developing other tumors. Diagnostic Pathology: Familial Cancer Syndromes, second edition, is an easy-to-use, one-stop reference for information on hereditary cancer syndromes, including differential diagnosis and management, that offers a templated, highly formatted design; concise, bulleted text; and superior color images throughout. Contains all the information necessary to determine whether a neoplasm typically encountered in daily practice is sporadic or related to a familial cancer syndrome Features a revised structure to keep you up to date: Part I includes more than 80 detailed chapters describing diagnoses associated with familial cancer syndromes; Part II contains more than 70 chapters with detailed descriptions of major syndromes (cross-referenced with diagnoses); and Part III features a molecular factors index that includes a complete description of each known gene associated with a familial cancer syndrome Contains updated chapters with newly classified GI, neurology, multiple organ, eye, endocrine, GYN, and kidney tumors, as well as more than 20 entirely new chapters covering recently recognized syndromes Incorporates up-to-date molecular findings and their significance for familial cancer syndromes; new techniques and technologies being used to discover gene mutations and other alterations; and details on personalized medicine targeted to specific genes Features more than 2,200 images throughout, including clinical and radiological images, algorithms, graphics, gross pathology, histology, and a wide range of special and immunohistochemical stains—all carefully annotated to highlight the most diagnostically significant factors Features time-saving bulleted text, key facts in each chapter, an extensive index, and numerous tables for quick reference and thorough understanding

Diagnostic Pathology: Familial Cancer Syndromes features a comprehensive review of the top 56 inherited tumor syndromes associated with neoplasms, which every surgical pathologists diagnoses in their daily sign-out practice. With over 175 chapters and written by well-known experts in the field, this book seeks to help surgical pathologists, clinicians, fellows, and residents understand the critical differences in diagnosing familial tumors and differentiating these from the sporadic counterpart. Besides the well-described pathology of these syndromes, the clinical implications on diagnosing these syndromes are also presented in detail. This book will guide pathologists and clinicians to master diagnostic criteria when diagnosing tumors associated with inherited tumor syndromes. The chapters are organized in 3 parts: The 1st part, "Overview of Syndromes" has the detailed description of the major syndromes within 56 chapters, genes involved, associated tumors, and diagnostic criteria. This part also contains tables that may be helpful in better classifying the diseases and the associated syndromes. Each syndrome described includes all benign and malignant tumors occurring in that specific syndrome including the differential diagnosis. The 2nd part, "Syndromes By Specific Diagnosis", discusses in detail, the diseases occurring within the syndromes described in part 1. The diagnoses are conveniently grouped according to the gland/organ/tissue involved. Distinct diseases are described by highlighting the characteristics of the tumors according to the different syndromes in which they occur. The book describes in detail some of the distinct characteristics of tumors found in inherited tumor syndromes that distinguishes these tumors from tumors in a sporadic setting. Each diagnosis includes definitions, terminology, etiology, pathogenesis, demographics, clinical presentations, therapy, prognosis, gross and microscopic pathology, differential diagnoses, and special studies including immunohistochemistry and molecular/genetics. Every diagnosis is discussed in concise, bulleted text that highlights the most diagnostically significant factors. The 3rd part is "Syndromes by Organ Location". This is also divided by organ/subspecialty and distributed among 40 chapters. This part has tables with "easy-to-find" possible syndromes by organ, with numerous tables including the differential diagnosis. Augmenting the text discussion are numerous gorgeous medical images, including clinical images, gross pathology, histology, and a wide range of special and immunohistochemical stains. Each image is carefully annotated to highlight the most diagnostically significant factors. Finally, this book features the classic benefits of all Amirsys® titles, including time-saving bulleted text, key facts in each chapter, stunning annotated images, extensive index, and Amirsys eBook Advantage(tm), an online version of the print book with larger images and fully searchable text. FEATURES: · Tables for easy reference and thorough understanding · 3 parts divided up for ease of understanding of familial syndromes as related to syndrome overviews, specific diagnoses, and organ location · Features the classic benefits of all Amirsys® titles, including time-saving bulleted text, Key Facts in each chapter, stunning annotated images, and an extensive index · Amirsys eBook Advantage(tm), an online version of the print book with fully searchable text

Molecular genetics has revolutionized our understanding of the susceptibility to and pathogenesis of cancer and is heralding the era of 'molecular oncology'. This progress is well illustrated by the gain in knowledge accumulated since the release of 'Familial Cancer' in 1985 - known among experts as the 'yellow book'. Cancer genes can now be identified, mapped and sequenced, and this technology has resulted in presymptomatic testing of persons at risk and the development of preventive therapeutic measures. This book provides an update of the latest advances by international experts in the field of hereditary cancer, with special emphasis on the needs of medical practice. The first part is devoted to a discussion of the mechanisms by which predispositions lead to breast and ovarian cancer, intestinal cancer, neoplasia of endocrine glands, and tumors in rare cancer syndromes. Attention is also given to epidemiological aspects of familial cancer occurrence. The second part covers genetic counseling and testing of members of high-risk families, as well as the prevention and treatment of hereditary cancer. Clearly written and well-organized, this book provides essential information not only for molecular geneticists and epidemiologists, but also for genetic counselors and oncologists.

Part of the highly regarded Diagnostic Pathology series, this updated volume by Joel K. Greenson, MD, is a visually stunning, easy-to-use reference covering all aspects of gastrointestinal pathology. Outstanding images – including gross pathology, a wide range of pathology stains, and detailed medical illustrations – make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. Packed with even more high-resolution images than the previous edition – more than 2,500 in all – depicting virtually any GI specimen you’re likely to see. Thoroughly updated content, including new information on drug-induced GI diseases such as olmesartan enteropathy, molecular testing in GI cancers, familial cancer syndromes in the GI tract, and the molecular biology of GI tract tumors as it relates to precision medicine and targeted therapy.

There are a number of hereditary cancers whose formation can be ascribed to a single gene, which unlike most types of cancers can be used for cancer risk reduction and early detection. Diagnosis and Management of Hereditary Cancer summarizes these and presents for readers the field of brain cancer genetics in a series of 50 tables. These tables each organize known research from different initial observations, to help best diagnose. Clinicians can use symptoms to extrapolate to specific conditions and associated genes, or begin with genes to connect with common symptoms and disorders. Together these diagnostic methods when met in daily clinical practice will allow clinicians to identify the possibility of a hereditary condition. Information organized in this way is not presently available in a single reference until now. This volume will elevate the care of hereditary cancer patients with practice-enhancing information and enhance development of the field by stimulating better diagnosis, management, and treatment. Features a unique table-based presentation of 50 aspects of hereditary brain cancer Analyzes genetics, genetic testing, and clinical features of multiple cancers Reviews clinical features for multiple hereditary cancer syndromes Presents a landscape picture book-style layout for better view of tabular information Provides a table-based presentation to better access information