Essential Cns Drug Development
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Essential CNS Drug Development
Author | : Amir Kalali,Sheldon Preskorn,Joseph Kwentus |
Publsiher | : Cambridge University Press |
Total Pages | : 219 |
Release | : 2012-06-07 |
Genre | : Medical |
ISBN | : 9780521766067 |
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Presents the complicated process of CNS drug development in a way that is engaging and informative for professionals and students.
Essential CNS Drug Development Edited by Amir Kalali Et Al
Author | : Amir Kalali |
Publsiher | : Unknown |
Total Pages | : 228 |
Release | : 2014-05-14 |
Genre | : Central nervous system stimulants |
ISBN | : 1139568760 |
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Presents the complicated process of CNS drug development in a way that is engaging and informative for professionals and students.
Modern CNS Drug Discovery
Author | : Rudy Schreiber |
Publsiher | : Springer Nature |
Total Pages | : 285 |
Release | : 2021-06-17 |
Genre | : Medical |
ISBN | : 9783030623517 |
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This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.
Principles of CNS Drug Development
Author | : John Kelly |
Publsiher | : John Wiley & Sons |
Total Pages | : 324 |
Release | : 2009-10-27 |
Genre | : Medical |
ISBN | : 0470682914 |
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This title acts as a primer, giving students and newcomers to the field an opportunity to learn about the breadth of the CNS drug discovery. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery. Key Features: Discusses in detail the key stages of CNS drug discovery, outlining the particular requirements and obstacles for CNS drugs Addresses safety concerns and future drug targets Provides succinct background information about the major CNS diseases Examples of specific drugs are used throughout to describe the development of a new drug from conception to clinical use and post-market surveillance Primary reasons for drug failure are given for each stage
Critical Pathways to Success in CNS Drug Development
Author | : Neal R. Cutler,John J. Sramek,Michael F. Murphy,Henry Riordan,Peter Biek,Angelico Carta |
Publsiher | : John Wiley & Sons |
Total Pages | : 272 |
Release | : 2010-01-22 |
Genre | : Medical |
ISBN | : 1444318586 |
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Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations
Frontiers in CNS Drug Discovery
Author | : Atta-ur- Rahman,M. Iqbal Choudhary |
Publsiher | : Bentham Science Publishers |
Total Pages | : 264 |
Release | : 2017-12-19 |
Genre | : Medical |
ISBN | : 9781681084435 |
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Frontiers in CNS Drug Discovery is a book series devoted to publishing reviews which highlight the latest advances in drug design and discovery for disorders of the central nervous system (CNS). Eminent scientists write contributions on all areas of CNS drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series is essential reading for all pharmaceutical scientists involved in CNS drug design and discovery who wish to keep abreast of rapid and important developments in the field. The third volume of this series brings reviews on brain tumor treatment, neurodegeneration, hyperalgesia, cholinesterase inhibition and much more.
Translational Medicine in CNS Drug Development
Author | : George G. Nomikos,Douglas E. Feltner |
Publsiher | : Academic Press |
Total Pages | : 458 |
Release | : 2019-06-18 |
Genre | : Medical |
ISBN | : 9780128031643 |
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Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia
Frontiers in CNS Drug Discovery
Author | : Atta-ur Rahman,M. Iqbal Choudhary |
Publsiher | : Bentham Science Publishers |
Total Pages | : 653 |
Release | : 2011-08-12 |
Genre | : Medical |
ISBN | : 9781608051595 |
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"Frontiers in CNS Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design an