Spike

SHORTLISTED FOR THE ORWELL PRIZE FOR POLITICAL WRITING 2022 THE TIMES SCIENCE BOOK OF THE YEAR A GUARDIAN BEST POLITICS BOOK OF THE YEAR A TOP 5 SUNDAY TIMES BESTSELLER *Revised and updated edition with new chapter reflecting on the impact of Covid-19 two years on, and what come next* Did the UK government really 'follow the science' throughout the Covid-19 pandemic, as it claims? As head of the Wellcome Trust, Jeremy Farrar was one of the first people in the world to hear about a mysterious new disease in China - and to learn it could readily spread between people. A member of the SAGE emergency committee, Farrar was a key figure in both the UK and the World Health Organization at the onset of the Covid-19 pandemic amid great uncertainty, fast-moving situations and missed opportunities. Spike is his widely acclaimed inside story. His account casts light on the UK government's claims to be 'following the science' and is informed not just by Farrar's views but by interviews with other top scientists and political figures.

This career-spanning monograph is a visual celebration of Spike Lee's life and career to date. Featuring hundreds of never-before-seen photographs by David Lee, Spike's brother, this book includes behind-the-scenes, insider images that underscore his creative process, and his significant impact on the culture at large. Print run 15,000.

The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to understand about them. Drawing on decades of research in neuroscience, Humphries explores how spikes are born, how they are transmitted, and how they lead us to action. He dives into previously unanswered mysteries: Why are most neurons silent? What causes neurons to fire spikes spontaneously, without input from other neurons or the outside world? Why do most spikes fail to reach any destination? Humphries presents a new vision of the brain, one where fundamental computations are carried out by spontaneous spikes that predict what will happen in the world, helping us to perceive, decide, and react quickly enough for our survival. Traversing neuroscience’s expansive terrain, The Spike follows a single electrical response to illuminate how our extraordinary brains work.

In the four years between 1881 and 1885, Canada was forged into one nation by the building of the Canadian Pacific Railway. The Last Spike reconstructs the incredible story of how some 2,000 miles of steel crossed the continent in just five years — exactly half the time stipulated in the contract. Pierre Berton recreates the adventures that were part of this vast undertaking: the railway on the brink of bankruptcy, with one hour between it and ruin; the extraordinary land boom of Winnipeg in 1881–1882; and the epic tale of how William Van Horne rushed 3,000 soldiers over a half-finished railway to quell the Riel Rebellion. Dominating the whole saga are the men who made it all possible — a host of astonishing characters: Van Horne, the powerhouse behind the vision of a transcontinental railroad; Rogers, the eccentric surveyor; Onderdonk, the cool New Yorker; Stephen, the most emotional of businessmen; Father Lacombe, the black-robed voyageur; Sam Steele, of the North West Mounted Police; Gabriel Dumont, the Prince of the Prairies; more than 7,000 Chinese workers, toiling and dying in the canyons of the Fraser Valley; and many more — land sharks, construction geniuses, politicians, and entrepreneurs — all of whom played a role in the founding of the new Canada west of Ontario.

Intended for neurobiologists with an interest in mathematical analysis of neural data as well as the growing number of physicists and mathematicians interested in information processing by "real" nervous systems, Spikes provides a self-contained review of relevant concepts in information theory and statistical decision theory.

Can an ugly dog with a heart of gold find a home? A warm and clever picture book for animal lovers of any breed. When Spike, the winner of the Ugliest Dog in the Universe contest, is abandoned by his owner, Joe, the boy next door, is determined—against all odds—to adopt him. Things look grim until Spike foils a neighborhood catnapping plan—and saves the day!

Solid and transparent data analysis is the most important basis for reliable interpretation of experiments. The technique of parallel spike train recordings using multi-electrode arrangements has been available for many decades now, but only recently gained wide popularity among electro physiologists. Many traditional analysis methods are based on firing rates obtained by trial-averaging, and some of the assumptions for such procedures to work can be ignored without serious consequences. The situation is different for correlation analysis, the result of which may be considerably distorted if certain critical assumptions are violated. The focus of this book is on concepts and methods of correlation analysis (synchrony, patterns, rate covariance), combined with a solid introduction into approaches for single spike trains, which represent the basis of correlations analysis. The book also emphasizes pitfalls and potential wrong interpretations of data due to violations of critical assumptions.