Experimental Research Methods In Orthopedics And Trauma

Covering all state-of-the-art experimental research methods in orthopedic surgery and trauma From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this "roadmap" at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care. Special Features: Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies – spanning topics from fracture fixation to gait analysis to bone remodeling Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, Experimental Research Methods in Orthopedics and Trauma is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology, apply its findings, and participate fully in research activities.

Covering all state-of-the-art experimental research methods in orthopedic surgery and trauma From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this "roadmap" at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care. Special Features: Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies – spanning topics from fracture fixation to gait analysis to bone remodeling Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, Experimental Research Methods in Orthopedics and Trauma is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology, apply its findings, and participate fully in research activities.

Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues, Second Edition reviews how a wide range of materials are modeled and applied. Chapters cover basic concepts for modeling of biomechanics and biotribology, the fundamentals of computational modeling of biomechanics in the musculoskeletal system, finite element modeling in the musculoskeletal system, computational modeling from a cells and tissues perspective, and computational modeling of the biomechanics and biotribology interactions, looking at complex joint structures. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and biomechanical engineers, and academics in related fields. This important new edition provides an up-to-date overview of the most recent research and developments involving hydroxyapatite as a key material in medicine and its application, including new content on novel technologies, biomorphic hydroxyapatite and more. Provides detailed, introductory coverage of modeling of cells and tissues, modeling of biomaterials and interfaces, biomechanics and biotribology Discusses applications of modeling for joint replacements and applications of computational modeling in tissue engineering Offers a holistic perspective, from cells and small ligaments to complex joint interactions

This exhaustive reference includes new chapters and pedagogical features, as well as—for the first time—content on managing fragility factures. To facilitate fast, easy absorption of the material, this edition has been streamlined and now includes more tables, charts, and treatment algorithms than ever before. Experts in their field share their experiences and offer insights and guidance on the latest technical developments for common orthopaedic procedures, including their preferred treatment options.

Applying new technologies, presenting your experience, and, of course, thinking of your current practice in the light of new evidence, needs some understanding of clinical research methodology. This book is not a textbook, but a brief guidance for clinical research practice. It aims at bridging the different points of view of statisticians and clinicians, but does not replace personal meetings and discussions between both professions at the earliest step of a clinical study. We hope that you find this book enjoyable, easy to read and understand, and helpful for improving your research skills. "Me, the editors, and the authors hope that this book will help you to sort and focus your ideas when setting up a clinical study, and to understand why certain information should be expressed in this or that fashion, how data should be compiled, analyzed, and presented. This book is neither exhaustive nor complete; it just fits better into your daily business." - David L Helfet

This book is written as a comprehensive guide for residents and young orthopaedic surgeons embarking on research, especially for those doing so for the very first time. It is specially designed to cater to the needs of trainees in the region preparing their theses for masters or fellowship degrees in orthopaedic surgery. It provides a detailed insight on the importance of strategic planning, organisational ability, resourcefulness, innovativeness and creativity to produce good research. Even more crucial is the necessity to have dedication, perseverance and strong commitment to pursue research. Infra-structural, technical, manpower and funding support are equally important. It describes how the investigator must plan his research well and outlines the strategies he could adopt to write an application for the much needed research grant. The book presents the basic methodology for animal experimentation research, histological techniques, biomechanical testing, microvascular surgery and cell culture techniques including tissue engineering. Also featured are the latest developments in the various clinical sub-specialties in orthopaedics & reconstructive surgery: spine, hip, knee, paediatrics, hand and oncology, highlighting research opportunities in the various clinical disciplines that could be explored. It ends with a guide on how to write the finished product — an article for a journal or a thesis/dissertation for a post-graduate examination. The final chapter outlines how total objective evaluation of a young researcher's output should be conducted. Contents:Planning ResearchAnimal Experimental SurgeryHistological and Other Specialised TechniquesBiology of Healing of Musculo-Skeletal TissuesBiomechanics of Musculo-Skeletal TissueResearch in Microvascular SurgeryTissue Engineering and Cell CultureCadaveric ResearchOpportunities in Clinical ResearchWriting the Finished Product Readership: Upper-level undergraduates, graduate students, researchers and academics in orthopaedic surgery, reconstructive surgery, general surgery, internal medicine, obsterics and gynaecology. Keywords: