Exposure Factors Handbook

The Chinese Research Academy of Environmental Sciences (CRAES) has conducted the Environmental exposure related activity pattern research of Chinese population (Adults). Exposure Factors Handbook of Chinese Population (Adults) was compiled based on the results from this study. Highlights of the Chinese Exposure Factors Handbook is a brief introduction to the content of Exposure Factors Handbook of Chinese Population (Adults). In each chapter, definitions, possible influence factors, and survey methods have been introduced, followed by recommended values for urban/rural areas, different genders, age groups and regions with information of mean, median and P5, P25, P75, P95 values. With the abundant data and tables, readers are provided with an accessible and comprehensive overview of Chinese exposure factors. The first and only one covering Chinese exposure factors, which have been absent until now and are essential for the exposure and risk assessment of environmental agents Presents several tables on ingestion rates, as well as activity biology and residential factors based on data from a national survey Provides a brief but comprehensive understanding of the environmental exposure-related factors for the Chinese population

Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.