Fetal And Neonatal Brain Injury

Now in its third edition, this is a comprehensive survey of fetal and neonatal brain injury arising from hypoxia, ischemia or other causes. The volume spans a broad range of areas from epidemiology and pathogenesis, through to clinical manifestations and obstetric care, and then on to diagnosis, long-term outcomes, and medico-legal aspects. An important theme running throughout is to highlight scientific and clinical advances that have a role to play in minimising risk, improving clinical care and outcomes.

Authoritative, practical clinical text giving clear management advice on diagnosis, treatment and outcomes of all fetal and neonatal brain injuries.

Authoritative, practical clinical text giving clear management advice on diagnosis, treatment and outcomes of all fetal and neonatal brain injuries.

An examination of legal measures which might be used to solve the problem of fragmentation of patents in genetics.

International Reviews of Child Neurology Series No. 13 Given the tremendous advances in the last five years in the understanding of acquired neonatal brain injury and in the care of affected newborn infants, this book provides a timely review for the practising neurologist, neonatologist and pediatrician. The editors take a pragmatic approach, focusing on specific populations encountered regularly by the clinician. They begin by addressing aspects of fetal neurology and the interpretation of fetal imaging studies. They then follow a “bench to bedside” approach to acquired brain injury in the preterm and term newborn infant in the next chapters. The contributors, all internationally recognized clinician scientists, provide the clinician reader with a state-of-the art review in their area of expertise. The final section of the book address special populations and concerns, areas that are largely overlooked in existing neurology textbooks. Each of these areas has seen considerable advances in the last five years and is of increasing relevance to the neurologist and neonatologist clinician. The comprehensive nature of each section (from basic science to acute clinical care to outcomes) should appeal broadly to scientists and allied health professionals working in neonatal neurology. Readership Paediatric neurologists, neonatologists, neurologists and paediatricians, clinicians in child development, child health researchers and allied health professionals (in physiotherapy, occupational therapy, speech therapy and psychology). Trainees in these areas.

The immature brain is vulnerable to prenatal and postnatal stress, which may produce brain damage leading to neurological dysfunction in survivors. The articles in this special issue provide new insights into the pathophysiology and treatment of developmental brain injuries and functional outcomes. Information obtained using preclinical models as well as data from clinical studies emphasize the influence of hypoxia-ischemia, excitotoxicity, oxidative stress, seizures and inflammatory mediators on the outcome of developmental brain injury and ultimate neurological outcome. Importantly, several papers report preclinical tests of new therapies that show real promise in preventing injury to the developing brain including erythropoietin, melatonin and steroids. This publication will be of interest to both clinicians and basic scientists who are interested in the developing nervous system, its vulnerability to various pathophysiological processes and the eventual consequences for neurologic development.