Fish As Model Organism For Skeletal Diseases

This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.

In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

The zebrafish is the most important fish model in developmental and genetic analyses. This book contains 19 review articles covering a broad spectrum of topics, from development to genetic tools. The contents range from early development, the role of maternal factors and gastrulation, to tissue differentiation and organogenesis, such as development of the organizer, notochord, floor plate, nervous system, somites, muscle, skeleton and endoderm. The genetic tools cover morpholino knock-down, transgenics, fish cloning, transposons and genome evolution. The book also includes two chapters on genome mapping and embryonic stem cells in medaka, another important model fish. Summarizing the state-of-the-art studies of the zebrafish model and focusing on the molecular aspects of development, this book is a valuable reference for students learning the basic aspects of the zebrafish model, and for researchers seeking resources in zebrafish research. Contents:The Role of Maternal Factors in Early Zebrafish Development (F Pelegri)Gastrulation in Zebrafish (F Ulrich & C-P Heisenberg)Development of the Zebrafish Organiser and Notochord (K A Thomas & D L Stemple)Formation and Functions of the Floor Plate (J Tian & K Sampath)Form and Function in the Zebrafish Nervous System (M Hendricks & S Jesuthasan)Development of the Primary Nervous System of the Zebrafish Embryo (U Strähle & V Korzh)Making Scents: Development and Function of the Olfactory Sensory System (K E Whitlock)Somites Segmentation: A View from Fish (H Takeda & Y Saga)Vertebrate Somite Development, Notch Signaling and Others (Y-J Jiang)Molecular Regulation of Fish Muscle Development and Growth (S J Du)Skeletogenesis in Zebrafish Danio rerio: Evolutionary and Developmental Aspects (S Fisher & P M Mabee)Endoderm Formation in Zebrafish (N B David et al.)Gene 'Knockdown' Approaches Using Unconventional Antisense Oligonucleotides (E Chen et al.)Transgenic Fish for Developmental Biology Studies (Z-Y Gong et al.)Cloning the Zebrafish (B Ju et al.)Applications of Transponsable Elements in Fish for Transgenesis and Functional Genomics (P B Hacketts et al.)Evolution of the Zebrafish Genome (J H Postlethwait)Medaka Genome Mappling for Functional Genomics (H Mitani et al.)Medaka Embryonic Stem Cells (Y-H Hong & M Schartl) Readership: Upper level undergraduates, graduate students, academics and researchers in cell & molecular biology, fish & marine biology and genetics. Keywords:Zebrafish;Medaka;Embrynonic Development;Axial Structures;Neurogenesis;Somites;Transgenics;GenomeKey Features:Contributed by active researchers working in the field of developmental biology of the zebrafish and medakaCovers essentially all major topics from early development to organogenesis as well as several most important genetic toolsRepresents most updated reviews in selected areas of the rapidly developing field