Gluten Related Disorders

Gluten-related disorders are prevalent worldwide, especially in developing countries. These diseases have similar clinical manifestations. Although they are characterized by a specific pathophysiological response to ingestion of gluten, differential diagnosis of these disorders is very challenging. Failure to diagnose and treat these disorders at an early stage, can lead to irreparable health and cost damages. Gluten-Related Disorders: Diagnostic Approaches, Treatment Pathways, and Future Perspectives solves this problem by reporting up-to-date scientific findings that allow for faster, more accurate diagnosis of gluten-related disorders as well as guidance on treatment options. By identifying the distinctive features of each of the gluten-related disorders, the chapters lead readers to optimal diagnosis and treatment options as well as better research designs for future research studies on the pathogenesis of these disorders. This reference provided by experts in the field is perfect for researchers, scientists, and medical practitioners who are involved in addressing gluten-related disorders. Provides a comprehensive overview on all aspects of gluten-related disorders, incorporating many up-to-date scientific findings Highlights the differences and overlaps in clinical presentations of gluten-related disorders in order to aid differential diagnosis Presents the current understanding of the pathogenesis of gluten-related disorders, which can be used to inform future research endeavors

A Clinical Guide to Gluten-Related Disorders provides primary health care providers the succinct material they need to immediately evaluate and support their patients. Gluten-related disorders have a wide presentation, and this text covers the recognition, evaluation, and multi-disciplinary approach to the management of disease. Readers will benefit from the general overview of gluten intolerance and from the common sense approach to developing treatment and dietary plans. Clinical vignettes offer clinicians real-life scenarios to help put the disease and its treatment in context for their patients.

This clinical casebook provides a comprehensive yet concise state-of-the-art review of gluten-associated disorders. Presented in a case-based format, the casebook reviews the overall management of celiac disease (from seronegative through classical to refractory disease) as well as non-celiac gluten/wheat sensitivity, with an emphasis on gastrointestinal and extra-intestinal manifestations of these disorders. Specific topics presented in these cases include, for instance, dermatitis herpetiformis, celiac disease and the liver, non-responsive celiac disease, celiac crisis, overlap with functional gastrointestinal disorders, and fructan intolerance. Two chapters written by expert dieticians share their experience in managing celiac disease and gluten/wheat sensitivity. Written by international experts in the field, Diagnosis and Management of Gluten-Associated Disorders: A Clinical Casebook is a valuable resource for both adult and pediatric gastroenterologists, hepatologists, primary care physicians, dermatologists, registered dieticians, trainees, and researchers interested in gluten-associated disorders.

Coeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provides an overview of the scientific background, mechanisms involved, and emphasizes the translational effect of research on clinical practice. Highlighted throughout are insights into future research areas likely to have a crucial impact in the clinical management of these common conditions. The book is perfect for researchers and gastroenterologists involved in Coeliac Disease and other gluten-related disorders. Presents both research and clinically based perspectives on the most relevant issues of gluten-related disorders Provides a wide-ranging discussion and the most updated opinions by international experts in the field of coeliac disease and gluten-related disorders Translates the latest research insights into practical suggestions for specialists

This study by the University of Basque Country Gluten Analysis Laboratory analyzes the gluten free diet from different perspectives. The authors provide background information on gluten, celiac disease, and other pathologies related to gluten intake. Later chapters cover topics such as techniques for gluten detection in foodstuffs and additives, as well as techniques used in complex matrices. Given that the only effective treatment for celiac disease is a strict, lifelong, gluten-free diet, and that the ingestion of small amounts of gluten can cause major symptoms in gluten intolerants, in recent years there has been an increasing interest in gluten free foodstuffs. In fact, the gluten-free product market has become one of the most prosperous in the field of food and beverages. The book provides a detailed analysis of the nutritional composition of gluten-free foodstuffs and a comparison with their gluten containing analogues. While targeted towards clinicians and science professionals, such as those working to develop gluten-free foods, it also discusses the energy and nutrient content of a gluten-free diet and offers different nutritional education strategies to improve the eating habits and nutritional status of those living with celiac disease.

Celiac disease is a systemic autoimmune process and appears in genetically predisposed individuals, with a well-known cause, consisting in a permanent intolerance to gluten, a protein contained in the flour of wheat, rye, barley and oats. Worldwide celiac disease affects to 1% of the Caucasian and there is recent evidence that the disease is increasing in USA and Finland among other regions in the world. It is considered to be the most prevalent disease with a genetic predisposition. The clinical forms of presentation are varied. The classical form consisting of diarrhea, anemia and failure to thrive is still common in children, but in the adult patients the symptoms resemble the irritable bowel syndrome. Mono-symptomatic forms with extra-intestinal manifestations are frequent. Hematological, cutaneous, articular, hepatic, bone and neurological manifestations are often described. This protean presentation and the lack of awareness explain the delay in diagnosis and suggest that screening in high-risk groups is indicated. The publication of this book written mainly by Spanish and Latin-American clinicians, researchers, and teachers, demonstrates the wide interest and the involvement of different disciplines that are necessary to understand celiac disease and gluten-related pathologies, such as non-celiac gluten-sensitivity. This has a great impact in the general public and in the industry. However, the knowledge of non-celiac gluten-related pathologies remains scarce but presently in the process of being properly defined. This book also highlights the importance of recognizing non-celiac gluten-sensitivity and briefly discusses a new definition. It also provides some perspectives to take into account when studying celiac disease in China and Central America. It describes new observations in Mexico, El Salvador and Costa Rica. The psychosocial impact as studied and reported by Argentinean investigators also adds to the value of this book. Written with a multidisciplinary team, we think that this book could be of interest to a great variety of medical specialists. Due to the systemic nature and variable presentation of celiac disease it certainly is of interest to pediatricians, gastroenterologists, hepatologists, specialists in internal medicine, general practitioners as well as hematologists, immunologists, geneticists, pathologists, rheumatologists, dermatologists, neurologists, gynecologists, neurologists, psychiatrists, psychologists, orthopedic surgeons, specialists in rehabilitation medicine, endocrinologists. Being gluten the cause of these disorders, the food industry, dietitians and nutritionists will benefit from the valuable information presented in this book.

World-renowned gluten-related disorders expert Dr. Alessio Fasano presents the groundbreaking roadmap to a gluten-free lifestyle, and how millions can live better by going gluten free. For centuries, bread has been known as the “staff of life.” But for millions of Americans affected by gluten-related disorders, consuming gluten, the complex protein found in wheat, rye, and barley, can be hazardous to their health. In a recent poll presented by Scientific American, over 30% of Americans reported wanting to cut down or eliminate gluten from their diets; the gluten-free market is a $6.3 billion industry and continues to expand. Now, in Gluten Freedom, Alessio Fasano, MD, world-renowned expert and founder of Massachusetts General Hospital’s Center for Celiac Research, reveals the latest developments in scientific research and treatment, and the answers they provide for this rapidly expanding audience. This groundbreaking, authoritative guide is an invaluable roadmap for the newly diagnosed, for those already dealing with gluten-related issues, and for anyone who thinks they may have an issue with gluten. Distinguishing scientific fact from myth, Gluten Freedom explains the latest research, diagnostic procedures, and treatment/diet recommendations, helping consumers make the best choices for themselves and their families. Gluten Freedom also discusses important nutritional implications for behavior-related diagnoses such as autism and conditions such as depression, anxiety, and “foggy mind.” Other highlights include: • The differences between celiac disease, gluten sensitivity, and wheat allergy • Current best practices for gluten-related disorders at any age • Practical information on setting up a gluten-free kitchen, reading labels, and staying safe and healthy in a world filled with hidden sources of gluten • The psychological impact of a diagnosis and its effect on a family • Groundbreaking research for prevention and therapy • Reliable and accurate resources for patients, parents, and physicians • And even recipes for an authentic gluten-free Italian dinner from Dr. Fasano’s home kitchen

New from Mayo Clinic-the essential guide to living gluten-free. Whether diagnosed with celiac disease or just deciding if a gluten-free diet is right for you, Mayo Clinic Going Gluten-Free will help you create and maintain a gluten-free lifestyle. Both authoritative and approachable, the book includes core medical information on celiac disease in addition to focusing on practical, everyday issues, such as: --Determining if gluten-free is right for you --Common signs, symptoms and myths of celiac --Dealing with celiac if you are newly diagnosed --Maintaining a gluten-free lifestyle while traveling, during the holidays, on-the-go and at college --Helping your child manage a gluten-free diet --Properly reading and understanding food labels --A few recipes and meals to jumpstart your gluten-free life