Handbook Of Applied Biosecurity For Life Science Laboratories

By achieving a delicate balance between systems and practices, proper laboratory biosecurity reduces the risk of legitimate bioscience facilities becoming sources of pathogens and toxins for malicious use. Effective design and implementation of laboratory biosecurity depends on cooperation among individuals from diverse communities, including scientists, technicians, policy makers, security engineers, and law enforcement officials. Providing guidance to the broad international community, Laboratory Biosecurity Handbook addresses the objectives of biosecurity and the ways in which they overlap or conflict with those of biosafety. The book describes the risks of working with dangerous pathogens and toxins in the current era of international terrorism. The authors characterize the global spread of legitimate biotechnology and relate it to the rise of transnational terrorism, emphasizing the need for biosecurity measures even in legitimate bioscience. The book discusses biosecurity risk assessment-a practical methodology that allows laboratory management and biosafety/biosecurity officers to analyze and determine the level of risk, and serves as a basis for managing those risks. The book includes questionnaires that can assist the process of collecting data for a biosecurity vulnerability assessment, example standard operating procedures and memoranda of understanding, and other useful reference material. Addressing a variety of operating environments and the particular challenges they face when designing and implementing laboratory biosecurity, this book can assist bioscience facilities ranging from the large to the small, from those that focus on diagnosis or vaccine development, to those only minimally involved with infectious diseases. The detailed recommendations help avoid a "one-size-fits-all" approach to security and save limited resources. The book shows institutions how to develop and implement a biosecurity plan, and helps ensure that all components are included in the overall system, whether existing or new.

This book describes an adaptable biothreat assessment process to complement overall biorisk management programs, incorporating threat management and the unique natures of biological assets. Further, this book examines the nexus between public health, international security, and developing technologies, building a case for augmenting biosecurity to levels beyond the laboratory constraints. With the face of biological and biomedical sciences changing, this book describes how with proper biosecurity development, these can become assets, rather than liabilities, to secure our world from natural and man-made biological disasters. The world is changing rapidly with respect to developing threats, such as terrorism, and dual-use technologies, such as synthetic biology, that are challenging how we think about biosafety and biosecurity. Further, the fields of public health and international security are colliding, as both of these share the common enemy: intentional or natural biological incidents. To date, biosecurity has been limited to laboratory-level application, and complicating efforts, and lacks credentialed biosecurity professionals skilled in both the biological sciences and threat management techniques. The result is a fragmented field of practice, with tremendous need, from the lab to the outbreak. Underpinning these principles is the SARS-CoV-2 coronavirus pandemic, providing a historic milestone to examine biosecurity through a global lens. This book describes biosecurity as a set of practices and principles to be augmented out of the constrained laboratory environment, and applied to larger efforts, such as international threat reduction and biological incident management.

The BIOLOGICAL LABORATORY APPLIED BIOSECURITY AND BIORISK MANAGEMENT GUIDE is a definitive and comprehensive tutorial text that, for the first time, provides a specific reference for training Biorisk and Biosecurity students or other biological community professionals. The topics included range from a clear, concise definition of Biorisk from a laboratory biosecurity perspective, biosafety/biosecurity comparisons and contracts, U.S. and WHO regulations and guidance, a unique laboratory biorisk assessment model, bio-terrorism reality, public health issues, research topics, laboratory physical security, emergency planning, export control and conducting business in foreign countries among other germane topics of interest.The cascading events in the aftermath of 9/11/2001, and the biological attacks that immediately followed have given rise to a significant proliferation of biological laboratories working with dangerous pathogens both domestically and internationally. The quest to develop effective medical countermeasures, conduct research, and provide safe and secure laboratory environments has also resulted in significant increases in funding. The expansion of this capacity has also resulted in the creation of a myriad of legislation, regulations and guidelines that are designed to protect laboratory staff, the public and ensure that these pathogens are properly secured. Ultimately, the convergence of these issues has contributed to the emergence of a new security subject matter expert category, Biological Security Professional. Currently there exists very few security management professionals specifically trained in biological security and biorisk management, to meet the needs and demand world-wide. The intent of this manual is to provide the fundamental information for new security practitioners just entering the field and the more experienced professional that is seeking to transition into the field of biological laboratory security and biorisk management. There is compelling evidence suggesting that the need for the biosecurity specialty subject matter expert will continue to grow exponentially in the near and long term, throughout the world. The ultimate goal is to assist in the proliferation of One Health world-wide and to create a professional discipline to prevent and mitigate the full spectrum of biological risks, threats and vulnerabilities

This book describes the risks of working with dangerous pathogens and toxins in the current era of international terrorism. The authors characterize the global spread of legitimate biotechnology and relate it to the rise of transnational terrorism, emphasizing the need for biosecurity measures even in legitimate bioscience. This second edition is considerably longer than the first and includes several new chapters and sections, with the final two-thirds of the book entirely reorganized.

The first training manual for new staff working in BSL3/4 labs. This guide is based on a course developed in 2007 by the EU COST action group 28b which serves as a standard for many courses BSL3/4 training courses worldwide. The four-day course consists of lectures and practical training with the lecturers covering all the different possibilities of organising a BSL-3/4 lab including the adaptation to the local requirements of biosafety, safety at work, and social regulations. This book covers bio-containment, hazard criteria and categorisation of microbes, technical specifications of BSL-3 laboratories and ABSL-3 laboratories, personal protective gear, shipping BSL-3 and BSL-4 organisms according to UN and IATA regulations, efficacy of inactivation procedures, fumigation, learning from a history of lab accidents, handling samples that arrive for diagnostic testing and bridging the gap between the requirements of bio-containment and diagnostics. Course participants can not only use the book for their actual training event but it will remain a useful reference throughout their career in BSL3/4 labs.

Aeromicrobiology provides a detailed and systematic analysis of the microbial communities and toxins collectively called bioaerosols that can be found in air. It provides information on the basics of Aeromicrobiology, the fate and transport of microorganisms in air, and the fundamental differences between intramural and extramural Aeromicrobiology. Leaning heavily on the current state of science, detailed information on the sampling and analysis of bioaerosol samples is provided. Subsequent chapters comprehensively discuss various airborne microbial groups and toxins, while the final chapter is dedicated to bioaerosol control strategies, biosafety, and biosecurity. There are limited resources on Aeromicrobiology. In rare instances where there are resources on Aeromicrobiology, they are often restricted to chapters in books or even supplementary materials. The emergence of new airborne pathogens, the aerosolization of microorganisms hitherto believed not to be airborne, and the proliferation of technologies for sampling, analysis, and control of bioaerosols makes it imperative for this title, which streamlines and succinctly presents the new body of knowledge in the field. Leans heavily on current state-of-the-art technologies used in sampling and analysis of bioaerosol samples such as metagenomics and sensor-based, hybrid technologies, among others Dedicates considerable attention to airborne and droplet-borne viruses, against the background of SARS-CoV-2 and related pathogens Comprehensively attends to regulatory aspects of bioaerosol control, highlighting various policies and regulations aimed at achieving biosecurity and curbing bioterrorism Helps researchers and policy makers in various fields who are often confronted with the need for basic information delivered in seamless style without loss of essential content

Managing biosecurity is everybody’s business. The book’s multi-site, multi-sectoral research contributes to an holistic, evidence-based strategy for managing plant biosecurity in complex contexts. The intent is to provide a starting point for all stakeholders in the biosecurity endeavor – policy personnel at all levels of governance, planners and regional developers, non-government organizations, community groups and individuals – to plan localized strategies that ‘fit’ national needs and constraints and the way people live their lives. In putting forward a ‘strategy’, we draw on many disciplines and cultural perspectives on a problem that is fundamentally a multidisciplinary and global issue. At the same time, the contributing researchers remain aware that such a strategy is always subject to local contextual factors and influences, indigenous and local knowledge and culture, and is regarded as a tool for planning, always subject to change.