Health And Environmental Applications Of Biosensing Technologies

With emerging biological threats from pathogenic microorganisms and increasing environmental pollutants, it is essential to ensure the safety needs of individuals and the ecosystem are met. Modern materials science and engineering has evolved over the years to better develop devices to test abnormalities. Affordability, accessibility, and reliability of any analytical system is the prime necessity for a modern diagnostic application. Health and Environmental Applications of Biosensing Technologies: Clinical and Allied Health Science Perspective presents a detailed overview on biosensor design systems and optimal fabrication technologies to create a greater impact on various industries and help organizations break existing performance tradeoffs to deploy biosensor technologies across inter/transdisciplinary businesses. The book presents novel and emerging trends in biosensor design and healthcare applications focused on API detection, communicable/non-communicable disease diagnosis, food quality monitoring, agro-environmental analysis, bio-defense, and industrial pollutant sensing. In addition, wearable biosensors, commercial products, and safety regulations for biosensing technologies are summarized. Provides a fundamental understanding on biosensor system design, biomarkers for communicable/non-communicable diseases, and bioreceptor immobilization techniques Integrates information covering biosensing technologies for clinical diagnosis, API detection, industrial/environmental monitoring, agro-livestock healthcare, and disease control Provides information on principles, advanced trends, and approaches for wearable biosensors Covers market trends with biosensing technologies/products and their commercial challenges

Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. Describes advanced nanomaterials for biosensor applications Relates the properties of available nanomaterials to specific biomarkers applications Includes diagnosis and electrochemical studies based on biosensors Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies Describes novel strategies for developing a new class of assay systems to retrieve the desired health information

Sensor Technologies: Healthcare, Wellness and Environmental Applications explores the key aspects of sensor technologies, covering wired, wireless, and discrete sensors for the specific application domains of healthcare, wellness and environmental sensing. It discusses the social, regulatory, and design considerations specific to these domains. The book provides an application-based approach using real-world examples to illustrate the application of sensor technologies in a practical and experiential manner. The book guides the reader from the formulation of the research question, through the design and validation process, to the deployment and management phase of sensor applications. The processes and examples used in the book are primarily based on research carried out by Intel or joint academic research programs. “Sensor Technologies: Healthcare, Wellness and Environmental Applications provides an extensive overview of sensing technologies and their applications in healthcare, wellness, and environmental monitoring. From sensor hardware to system applications and case studies, this book gives readers an in-depth understanding of the technologies and how they can be applied. I would highly recommend it to students or researchers who are interested in wireless sensing technologies and the associated applications.” Dr. Benny Lo Lecturer, The Hamlyn Centre, Imperial College of London “This timely addition to the literature on sensors covers the broad complexity of sensing, sensor types, and the vast range of existing and emerging applications in a very clearly written and accessible manner. It is particularly good at capturing the exciting possibilities that will occur as sensor networks merge with cloud-based ‘big data’ analytics to provide a host of new applications that will impact directly on the individual in ways we cannot fully predict at present. It really brings this home through the use of carefully chosen case studies that bring the overwhelming concept of 'big data' down to the personal level of individual life and health.” Dermot Diamond Director, National Centre for Sensor Research, Principal Investigator, CLARITY Centre for Sensor Web Technologies, Dublin City University "Sensor Technologies: Healthcare, Wellness and Environmental Applications takes the reader on an end-to-end journey of sensor technologies, covering the fundamentals from an engineering perspective, introducing how the data gleaned can be both processed and visualized, in addition to offering exemplar case studies in a number of application domains. It is a must-read for those studying any undergraduate course that involves sensor technologies. It also provides a thorough foundation for those involved in the research and development of applied sensor systems. I highly recommend it to any engineer who wishes to broaden their knowledge in this area!" Chris Nugent Professor of Biomedical Engineering, University of Ulster What you’ll learnThe relevant sensing approaches and the hardware and software components required to capture and interpret sensor data. The importance of regulations governing medical devices. A design methodology for developing and deploying successful home- and community-based technologies, supported by relevant case studies. Health, wellness, and environmental sensing applications and how they work. The challenges and future directions of sensing in these domains. Who this book is for Sensor Technologies: Healthcare, Wellness and Environmental Applications is targeted at clinical and technical researchers, engineers, and students who want to understand the current state of the art in sensor applications in these domains. The reader gains a full awareness of the key technical and non-technical challenges that must be addressed in the development of successful end-to-end sensor applications. Real-world examples help give the reader practical insights into the successful development, deployment, and management of sensor applications. The reader will also develop an understanding of the personal, social, and ethical impact of sensor applications, now and in the future. Table of ContentsChapter One: Introduction Chapter Goal: Reader should understand the key challenges and drivers for sensor application development. The reader should also understand how sensor technologies can play a role in addressing some of the key challenges facing global society in the short to medium term. 1. Book overview 2. Drivers for Sensor Applications (Infrastructure Growth in Developing Countries, Advances in Energy Harvesting, New Applications, Cost reduction, Real-time monitoring of situations to avoid unplanned downtime, Security (personal and national), the internet of things). 3. Challenges for Sensor Applications (Power, Efficient Operation in Harsh Environments, Number of Deployable Nodes, Safety and Regulations, High Cost of Installation, Security and Reliability, sensor management) 4. Global Megatrends and the opportunities for sensing technologies o Water and Food Constraints o Aging Demographics o Public Health o Pandemics o Security Chapter 2: Sensing and Sensor Fundamentals Chapter Goal: Reader should understand existing sensor technologies, which can be used in healthcare, wellness, and environmental domains. They should also understand the role of smart sensors and smart phones as mobile sensing platforms and aggregators. 1. Sensing Modalities (Mechanical, MEMS, Optical, ISFET, μTAS) 2. Sensing Domains (Air, Water, Noise, Bacterial, Chemical, Kinematic, DNA, Physiological) 3. Functional Characterisation of Sensors o Communication methods – discrete, wired, wireless o Smart Sensors and Sensor Platforms § MSP430 (SHIMMER and telosB motes) § ATmega § PIC 4. Smart Phones as mobile sensor platforms 5. Selecting and specifying sensors Chapter 3 Key Sensor Technology Components – Hardware and Software Overview Chapter Goal: Reader should have a high level understanding of the key hardware and software components, which are necessary for the development of sensors systems and why technologies are selected for specific applications. 1. Overview – Sensor systems 2. MCU’s (TI MSP430, ATmega, PIC) a. ADCs b. Interrupts c. Real-time Clocks 3. Sensor Interfaces a. Digital b. Analog c. I2C 4. Communications – wired and wireless interfaces RS232/485, USB, Ethernet, FieldbusProprietary Short Range Wireless Protocols (e.g. ANT, BodyLAN, Sensium)Standard Short Range Protocols i. IEEE 802.15.6 ii. Bluetooth/Smart Bluetooth iii. 802.15.4 iv. UWB Medium Range i. Wi-Fi 5. Data storage (EEPROM, sd card, data forwarding) 6. Power management and Energy Harvesting 7. Operating Systems and Software Development Environments (SDK’s) Chapter 4 Sensor Network Architectures Chapter Goal: Reader should understand the various approaches to the design of sensor network architectures; scaling from body worn systems, to ambient sensing, to city-scale deployments. The reader should also understand the advantages and disadvantages of current and evolving sensor network architectures. 1. Sensor network architectures o Discrete Sensor o Sensor to aggregator o PAN/WPAN/smart clothing o Pervasive/Ambient sensor networks o Wide area networks (city-wide, country wide) 2. Challenges in developing and deploying sensor networks 3. Current and Proposed Solutions o Remote sensor management o Edge Processing o Power harvesting o New communication standards Chapter 5: Adding Vibrancy to Sensor Data Chapter Goal: Reader should understand the various methods to interpret and display sensor data to the user. They will understand the importance of creating a data analysis plan from the outset, and the different types of data analysis throughout the application stack. 1. Data Literacy – How can we intuitively answer questions with sensor data and contextualise answers 2. Data Quality a. Calibration b. Trust and Repudiation 3. Sensor Fusion – combining sensory data from disparate sources 4. Data Mining 5. Data Visualisation 6. Openness, data integration, virtual sensors 7. Exploiting the power of the cloud Chapter 6: Regulation and Standards Chapter Goal: Reader should understand the key technologies, which impact or influence the development of sensor deployment and applications including the emerging standards and regulatory considerations. 1. Regulatory Standards (US, EU, Japan) : why, which, and how standards impact your application 2. Regulatory Issues: Certification 3. Smartphones Considerations o Privacy and data security 4. Standards Bodies and Industry Groups o Continua Healthcare Alliance o ISO/IEEE 11073 5. Wearable Wireless Health Communication Standards Chapter 7: Biosensing in Everyday Life – Driving Biocontextual Aware Computing Chapter Goal: Reader should understand the social relationships that create opportunities and barriers for widespread, consumer-based biosensing. The reader should understand how the social world is shifting from sensor technologies of “should” to sensor technologies of “could” to facilitate new understandings of health and wellness and drive new methods and practices of personal data sharing. 1. Data Security and Ownership - Sharing and Managing Personal Data 2. Game Changing Pressure for Affordable Healthcare 3. Continuous, Personal Data is Improving Lives 4. Emerging Tech-Empowered Citizens 5. Sensing for Self-Discovery, Culture and Play 6. User feedback/Supporting sustainable human behaviours – leveraging the gaming culture Chapter 8: Development and Deployment of Sensor Technologies for Home and Community Settings Chapter Goal: Reader should understand how to design a sensor deployment for a home or community. The chapter informs the reader how to formulate the research question the deployment will address, how to develop prototypes, and manage and deploy them successful. The chapter will finish with exemplar case studies of real world sensor deployments. Study Design – The Right QuestionHome Deployment ElementsHome Deployment ManagementThe Prototyping Design ProcessCase Studies Chapter 9: Body Worn and Ambient Sensor Applications for Assessment, Monitoring, and Diagnostics Chapter Goal: Reader should at the end of this chapter have an understanding of the key characteristics of how body worn and ambient sensor applications, and how they vary according to the domain in which they are deployed. The reader will be presented with the key challenges faced in each domain, and emerging solutions for these challenges. 1. Drivers and Inhibitors (Incidence of chronic diseases, aging demographics, Adjusting provider compensation, prevention, medical work practice changes) 2. Hospital based sensing for assessment and diagnosis 3. Supervised Assessment and Monitoring in Community Settings 4. Home Based Applications o Clinical grade sensing for patient monitoring o Body worn sensing (e.g. PERS) for monitoring and alerting o Passive sensing for monitoring and alerting (e.g. ADL’s) 5. Key challenges Chapter 10: Wellness, Fitness and Lifestyle Chapter Goal: Reader should understand the key trends in how people use body worn sensors to manage their fitness and wellbeing. Key applications include: sensors for measuring activities in sports performance, activity/weight management and sleep tracking, 1. Drivers and Inhibitors 2. Sports and fitness applications (running, walking cycling, field sports) § Vital signs and physiological parameters § Fitness gaming – Wii Fit, Kinect § muscle movement, body stress levels, speed, distance, location § Fitness Statistics and Analysis 3. Outdoor Activities o Pressure (mountaineer and paragliding) o GPS (hiking, cycling, golf) 4. Obesity and weight management 5. Sleep o Baby Monitoring o Sleep Quality – health and social impacts o Sleep Apnoea Chapter 11: Environmental Monitoring for Health and Wellness Chapter Goal: Reader should understand how sensors and sensor networks are used for environmental monitoring, one of the key emerging applications domains. Apart from disaster monitoring, sensing also has the potential for air quality, weather monitoring, pollution etc.; with benefits for both urban and rural dwellers. 1. Drivers and Inhibitors o Correlations to health impacts 2. Home Sensing o Carbon Monoxide o Smoke Detectors o Passive Infrared (PIR) o Temperature o Sound o Sustainable Living 3. Smart Environments 4. Environmental Parameters (Noise, Water, Bacteria, Air Quality, Radiation, Urban Heat Islands) 5. Weather - Exceptional Event and Disaster Management Intelligence Chapter 12: Conclusions and Future Directions Chapter Goal: Reader should understand the key conclusions that the authors have outlined in the previous chapters. The reader should also gain an understanding of the key trends which will affect future sensor applications and how people will utilise these novel applications in their everyday lives. 1. Summary of the overall conclusions 2. Future Directions for Sensing o Use Centred Healthcare o Citizen centric sensing o Influence of urbanisation on health, wellness and lifestyle choices. o Sustainable human behaviour change

The main challenge in biosensor development is their application for various practical tasks to provide a continuous and reliable flow of information about the indicators of natural and industrial processes and the surroundings, so enabling adequate feedback and control. Biosensors can provide essential information, as the quality of life depends mainly on our knowledge about what we breathe, what we eat and how our bodies are able to metabolize the material, which we contact. This book includes 14 chapters, written by 52 authors and is focused on the applications of biosensors for monitoring the parameters of environment, the quality of food and biomarkers of health.

A biosensor is a detecting device that combines a transducer with a biologically sensitive and selective component. Biosensors can measure compounds present in the environment, chemical processes, food and human body at low cost if compared with traditional analytical techniques. This book covers a wide range of aspects and issues related to biosensor technology, bringing together researchers from 16 different countries. The book consists of 24 chapters written by 76 authors and divided in three sections: Biosensors Technology and Materials, Biosensors for Health and Biosensors for Environment and Biosecurity.

Electrochemical Nano-biosensors: Applications in Diagnostics, Therapeutics, Environment, and Food Management features a critical overview of different, recently reported nanomaterial-based electrochemical sensing and biosensing strategies. It is based on various analytical approaches for the point-of-care or POC healthcare related diagnostics, evaluation of contaminants, additives and adulterants in foods and environment management. Each section under the topic is discussed in its exhaustive detail, incorporating significant literature reviews spanning over two decades. The book critically analyzes issues and challenges for its applications in real world settings, universal applicability in resource limited sets-ups of remote areas, ease of integration with other sensing platforms, portability/miniaturization, and more. Takes account of the fact that nanomaterials are increasingly favored as labels for electrochemical immunoassay protocols for the development of highly sensitive and selective electrochemical sensing device Refines biosensors for real-world settings, academicians, healthcare professionals and industrialist who need to team up for the successful realization of POCT/LOCT devices Contains focused and targeted research coupled with other technological advances to help in the development of cutting-edge nanomaterial based electrochemical immunoassays with features of test-strip technology and lateral flow

This informative book compiles the most up-to-date applications of nanobiosensors in fields ranging from agriculture to medicine. The introductory section describes different types of nanobiosensors and use of nanobiosensors towards a sustainable environment. The applications are divided into four broad sections for easy reading and understanding. The book discusses how manipulation, control and integration of atoms and molecules are used to form materials, structures, devices and systems in nano-scale. Chapters in the book shed light on the use of nanosensors in diagnostics and medical devices. Application in food processing as well as in cell signaling is also described. Nanobiosensors have immense use, and this book captures the most important ones.

Advanced Sensor Technology: Biomedical, Environmental, and Construction Applications introduces readers to the past, present and future of sensor technology and its emerging applications in a wide variety of different fields. Organized in five parts, the book covers historical context and future outlook of sensor technology development and emerging applications, the use of sensors throughout many applications in healthcare, health and life science research, public health and safety, discusses chemical sensors used in environmental monitoring and remediation of contaminants, highlights the use of sensors in food, agriculture, fire prevention, automotive and robotics, and more. Final sections look forward at the challenges that must be overcome in the development and use of sensing technology as well as their commercial use, making this book appropriate for the interdisciplinary community of researchers and practitioners interested in the development of sensor technologies. Covers a range of environmental applications such as protection and improvement of water, air, soil, plants, and agriculture and food production; biomedical applications including detection of viruses, genes, hormones, proteins, bacteria, and cancer, and applications in construction such as fire protection, automotive, robotics, food packing and micro-machining Provides an outlook on opportunities and challenges for the fabrication and manufacturing of sensors in industry and their applicability for industrial uses Demonstrates how cutting-edge developments in sensing technology translate into real-world innovations in a range of industry sectors