Homeostasis

An overview of allostasis, the process by which the body maintains overall viability under normal and adverse conditions.

Interoception is the body-to-brain axis of sensations that originates from the internal body and visceral organs. It plays a unique role in ensuring homeostasis, allowing human beings to experience and perceive the state of their bodies at any one time. However, interoception is rapidly gaining interest amongst those studying the human mind. It is believed that beyond homeostasis interoception is fundamental in understanding human emotion and motivation and their impact upon behavior. That link between interoception and self-awareness is supported by a growing body of experimental findings. The Interoceptive Mind: From Homeostasis to Awareness offers a state-of-the-art overview of, and insights into, the role of interoception for mental life, awareness, subjectivity, affect, and cognition. Structured across three parts, this multidisciplinary volume highlights the role that interoceptive signals, and our awareness of them, play in our mental life. It considers deficits in interoceptive processing and awareness in various mental health conditions. But it also considers the equally important role of interoception for well-being, approaching interoception from both a theoretical and a philosophical perspective. Written by leading experts in their fields, all chapters within this volume share a common concern for what it means to experience oneself, for the crucial role of emotions, and for issues of health and wellbeing. Each of those concerns is discussed on the joint basis of our bodily existence and interoception. The research presented here will undoubtedly accelerate the much-anticipated coming of age of interoceptive research in psychology, cognitive neurosciences and philosophy, making this vital reading for anyone working in those fields.

Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. The companion volume, Homeostasis and Toxicology of Non-Essential Metals, Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers. All major essential metals of interest are covered in metal-specific chapters Each metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metal A common format is featured throughout this two volume edition

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Written by experienced nurse lecturers and a theatre nurse, Perioperative Practice highlights and explains the biological processes which can be disrupted by a major surgical procedure. Using the concept of homeostasis as a framework, the authors look at issues common to all surgical procedures such as the influence of anaesthesia on the nervous system or perioperative pain management. Individual chapters cover: the human body and principles of homeostasis the surgical approach and endoscopic procedures perioperative influences on body fluid homeostasis perioperative influences on immunological homeostasis and wound healing perioperative influences on cardiovascular homeostasis perioperative influences on respiratory homeostasis anaesthesia, stress and surgery pain and pain relief in the perioperative patient. Generously illustrated in colour and black and white, the text features further learning activities and useful summaries of key points. It provides an important resource and supporting text for all nurses undertaking courses in theatre work or related areas or already working in such areas.

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

The human body is composed of several systems and organs, consisting of millions of cells that need relatively stable conditions to function and contribute to the survival of the body as a whole. The maintenance of stable conditions for the cells against the variations of the external environment is an essential function of the body and is called homeostasis. As a consequence of the loss of homeostasis, a disease is manifested. This book aims to provide the reader with an up-to-date view of the self-regulatory mechanisms that are activated to achieve homeostasis, the pathways that are altered during the disease process, and how medicine can intervene to restore balance in critical patients.