Hybrid Mr Pet Imaging

The combination of two leading imaging techniques – magnetic resonance imaging and positron emission tomography – is poised to have a large impact and has recently been a driver of research and clinical applications. The hybrid instrument is capable of acquiring both datasets simultaneously and this affords a number of advantages ranging from the obvious, two datasets acquired in the time required for one, through to novel applications. This book describes the basics of MRI and PET and then the technical issues and advantages involved in bringing together the two techniques. Novel applications in preclinical settings, human imaging and tracers are described. The book is for students and scientists entering the field of MR–PET with an MRI background but lacking PET or vice versa. It provides practical details from experts working in the area.

This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting. Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.

This issue of MRI Clinics of North America focuses on Imaging of the PET/MR Imaging, and articles will include: Principles of PET/MR Imaging; Attenuation Correction of PET/MR Imaging; MR-Derived Improvements in PET Imaging; Neurological Applications of PET/MR; Oncological Applications of PET/MR Imaging on the Head and Neck; Oncological Applications of PET/MR Imaging on GYN/GU; PET/MR Imaging of Multiple Myeloma; Pediatric Nuances of PET/MR Imaging; Cardiac Applications of PET/MR Imaging; Logistics and Practical Considerations of MR Coils for PET/MR; Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment; Practical Clinical Considerations of PET/MR; Incremental value of FDG PET/MR in Assessment of Rectal Cancer, and more!

This book offers an excellent overview of the current applications of PET/MR imaging. Detailed information is provided on both its principal oncologic applications and its most important non-oncologic applications, such as assessment of cardiac disease, neurodegenerative brain imaging, and imaging of inflammatory disease. In addition, the future of PET/MR imaging is closely scrutinized, highlighting the anticipated major advances in the diagnostic value of hybrid imaging, the emerging role of PET/MR imaging in monitoring response in patients receiving targeted drug therapy, and progress toward the development of new tracers. An individual chapter is also devoted to pediatric imaging. The editors and authors are all well-known specialists in the field, with high levels of expertise in clinical applications and excellent publication records. The authors and editors represent both fields of hybrid imaging, in terms of nuclear medicine and radiology as to guarantee presentation of expertise and knowledge from both “worlds”. The book will be of value for all residents and consultants in radiology and nuclear medicine who have a dedicated interest in hybrid imaging.

In this issue of MRI Clinics, guest editors Prof. Minerva Becker and Dr. Valentino Garibotto bring their considerable expertise to the topic of Clinical Value of Hybrid PET/MRI. Combined PET/MRI has significant advantages over other imaging methods—a lesser radiation dose, excellent soft tissue contrast, numerous radiotracers available for PET, and more, making it a good choice for diagnostics and staging, as well as surgical planning. In this issue, top experts explore these advantages and more, helping you make the most of this relatively new dual-imaging modality in your practice. Contains 10 relevant, practice-oriented topics including breast imaging using PET/MRI; abdominal imaging using PET/MRI; brain imaging using PET/MRI; musculoskeletal imaging using PET/MRI; PET/MRI in radiation therapy planning; pediatric imaging using PET/MRI; and more. Provides in-depth clinical reviews on the clinical value of hybrid PET/MRI, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of PET Clinics focuses on Recent Advances in Imaging with PET, CT, and MR Techniques and is edited by Drs. Habib Zaidi, Abass Alavi and Drew A. Torigian. Articles will include: Total-body PET imaging: Developments in instrumentation; Prospects for total-body PET imaging using plastic scintillators; Total-body imaging: Potential clinical applications; New challenges for PET image reconstruction for total-body imaging; Advances in preclinical PET instrumentation; Applications of hybrid PET/MRI in CNS disorders; Applications of hybrid PET-MRI in MSK disorders; Assessment of total body atherosclerosis burden by PET-CT; Recent advances on CT and MR imaging in radiology; Potential impact of Total Body PET imaging in measuring global disease burden in systemic inflammatory disorders; Applications of PET-MRI in CV disorders; and more!

This book offers an overview of the clinical applications of PET/MR imaging through a case-based format. Hybrid PET/MRI provides functional and anatomical information via one setting offering superior imaging quality with lower radiation dose being administered to the patient. The cases in this book focus on the use of this technique in the diagnosis of oncologic, neurologic, cardiovascular, infectious and inflammatory, and pediatric diseases. Each case is presented with the patient history, protocols, interpretation of findings, and pearls and pitfalls accompanied by high quality PET/MR images. The major strength of this book is the discussion of both MRI and PET findings pertinent to each particular case. It expands the discussion of oncologic applications of this modality through a variety of cases that highlight staging, treatment response, and follow up. Illustrating a spectrum of PET/MRI clinical applications, PET/MR Imaging: A Case-Based Approach is a valuable resource for radiologists, nuclear medicine physicians, and residents.

This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.