Immunotoxicology And Risk Assessment
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Immunotoxicology and Risk Assessment
Author | : Dennis K. Flaherty |
Publsiher | : Springer Science & Business Media |
Total Pages | : 382 |
Release | : 2007-05-08 |
Genre | : Medical |
ISBN | : 9780306468100 |
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This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US Food and Drug Administration, as well as data applicable to western European Nations.
Investigative Immunotoxicology
Author | : Helen Tryphonas,Michel Fournier,Barry R. Blakley,Judit Smits,Pauline Brousseau |
Publsiher | : CRC Press |
Total Pages | : 788 |
Release | : 2005-01-27 |
Genre | : Medical |
ISBN | : 9781134393992 |
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Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus
Immunotoxicology Strategies for Pharmaceutical Safety Assessment
Author | : Danuta J. Herzyk,Jeanine L. Bussiere |
Publsiher | : John Wiley & Sons |
Total Pages | : 433 |
Release | : 2008-11-21 |
Genre | : Medical |
ISBN | : 9780470386378 |
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An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates Helps readers understand the significance of the methods and approaches to immunotoxicology testing Aids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing Offers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune system Includes chapter authors from across the pharma industry, bringing a real-world and applied perspective to immunotox testing
Immunotoxicity Testing
Author | : Rodney R. Dietert |
Publsiher | : Humana |
Total Pages | : 430 |
Release | : 2016-08-23 |
Genre | : Medical |
ISBN | : 1493957317 |
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Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
Identifying and controlling immunotoxic substances
Author | : Anonim |
Publsiher | : DIANE Publishing |
Total Pages | : 92 |
Release | : 1991 |
Genre | : Immunotoxicology |
ISBN | : 9781428921573 |
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Introduction To Immunotoxicology
Author | : Jacques Descotes |
Publsiher | : CRC Press |
Total Pages | : 196 |
Release | : 2003-09-02 |
Genre | : Medical |
ISBN | : 9780203362549 |
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This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotoxicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro methods, biomarkers of immunotixicity and risk assessment.
Methods in Immunotoxicology
Author | : Gary R. Burleson,Jack H. Dean,Albert E. Munson |
Publsiher | : Wiley-Blackwell |
Total Pages | : 560 |
Release | : 1995 |
Genre | : Medical |
ISBN | : UOM:39015034897283 |
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This two-volume set provides comprehensive coverage of recent and novel approaches for the identification and characterization of immunotoxicants. The first work presents an overview of the field, discussion of experimental design, and methods for risk assessment and sound laboratory practice. Volume 2 covers macrophage function assays, the use of animal models with specific reference to heat resistance, and autoimmunity.
Pulmonary Immunotoxicology
Author | : Mitchell D. Cohen,Judith T. Zelikoff,Richard B. Schlesinger |
Publsiher | : Springer Science & Business Media |
Total Pages | : 465 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9781461545354 |
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Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.