Inflammatory Processes
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Inflammation and the Microcirculation
Author | : D. Neil Granger,Elena Senchenkova |
Publsiher | : Morgan & Claypool Publishers |
Total Pages | : 99 |
Release | : 2010 |
Genre | : Medical |
ISBN | : 9781615041657 |
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The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Fundamentals of Inflammation
Author | : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy |
Publsiher | : Cambridge University Press |
Total Pages | : 489 |
Release | : 2010-04-26 |
Genre | : Medical |
ISBN | : 9780521887298 |
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The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.
Inflammatory Processes
Author | : L. Gordon Letts,Douglas W. Morgan |
Publsiher | : Springer |
Total Pages | : 146 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9783034884686 |
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In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...
The Inflammatory Process
Author | : Benjamin W. Zweifach,Lester Grant,Robert T. McCluskey |
Publsiher | : Academic Press |
Total Pages | : 670 |
Release | : 2014-05-12 |
Genre | : Health & Fitness |
ISBN | : 9781483220796 |
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The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from cell surface phenomena and connective tissue to the role of the formed elements of the blood in inflammatory states, particularly in the light of the rapidly burgeoning literature on platelet physiology. The life history and functional capacities of leukocytes are also examined, along with chemotaxis, phagocytosis, and the mechanisms responsible for tissue damage in inflammation. Comprised of 10 chapters, this volume begins with an overview of the experimental approach to the study of inflammation, followed by a discussion on the biochemistry of the mammalian plasma membrane. The reader is then introduced to cell injury; chemotaxis; phagocytosis; and lysosomal mechanisms in the inflammatory process. Subsequent chapters deal with the inflammatory process at the cellular level, paying particular attention to neutrophil leukocytes; the metabolism and physiology of mononuclear phagocytes; the role of platelets in inflammatory reactions; and structural and biochemical characteristics of mast cells. This book will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.
The Resolution of Inflammation
Author | : Adriano Rossi,Deborah A. Sawatzky |
Publsiher | : Springer Science & Business Media |
Total Pages | : 240 |
Release | : 2008-03-17 |
Genre | : Medical |
ISBN | : 9783764375065 |
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This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Janeway s Immunobiology
Author | : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter |
Publsiher | : Garland Science |
Total Pages | : 135 |
Release | : 2010-06-22 |
Genre | : Medical |
ISBN | : 0815344570 |
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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
The Inflammatory Process
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 931 |
Release | : 1969 |
Genre | : Electronic Book |
ISBN | : 0127834508 |
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Molecular Biology of The Cell
Author | : Bruce Alberts |
Publsiher | : Unknown |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 0815332181 |
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