Integrated Approaches For Studying Hazardous Substances

Papers: tetrachloroethylene-contaminated drinking water and the risk of breast cancer; biomarkers of leukemia risk; biomarkers for assessing human female reproductive health, an interdisciplinary approach; bone lead as a new biologic marker of lead dose; utilization of DNA-protein cross-links as a biomarker of chromium exposure; modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity; 4 papers each on chlorinated organics, metals, and risk assessment, including: design of an epidemiologic study of drinking water arsenic exposure and skin and bladder cancer risk; and 5 papers on risk reduction. Illustrated.

This book presents environmental protection managers and advanced students in environmental studies programs with an overview of the principles, facts, multidisciplinary approaches, and some of the complex ities of the management of toxic substances. The text explores critical issues facing managers responsible for prevent ing and controlling problems associated with the manufacture,. transport, storage, use and disposal of chemicals. It does this from two perspectives. The first is a disciplinary perspective, that is environmental chemistry, of toxicology, engineering, economics, sociology and political science, all which playa role in implementing comprehensive programs to manage chemicals. The second perspective is from the view of industry, govern ment, academia and non-government organizations. For example, Chapter 5 is authored by technical managers of a major chemical company, Chap ters 6 and 12 by government scientists and managers respectively, and Chapter 10 by a respected member of the environmental lobby. An appreciation of these perspectives is very important for developing and running effective chemical management programs.

Hazard Assessment of Chemicals: Current Developments, Volume 2 contains authoritative articles, which provide a comprehensive review and evaluation of important information on chemical spills, and presents case studies that show the applications of methods and approaches to environmental and health hazard assessment of chemicals. The book is comprised of five subject reviews and two case studies of chemical spills. Experts tackle subjects on the use of simulation models to determine pollutant behavior and pollutant migration; use of microcosms to assess chemical effects on the properties of aquatic ecosystems; and metabolism and disposition of potentially hazardous chemicals in maternal-embryonic/fetal systems. Epidemiological approaches to chemical hazard assessment and a review of The National Toxicology Program (NTP) in the Department of Health and Human Services are also presented. Environmentalists, ecologists, toxicologists, public safety officers and workers, and those concerned with the health effects of chemical agents in the environment will find this text invaluable.