Large Scale Networks In Engineering And Life Sciences

This edited volume provides insights into and tools for the modeling, analysis, optimization, and control of large-scale networks in the life sciences and in engineering. Large-scale systems are often the result of networked interactions between a large number of subsystems, and their analysis and control are becoming increasingly important. The chapters of this book present the basic concepts and theoretical foundations of network theory and discuss its applications in different scientific areas such as biochemical reactions, chemical production processes, systems biology, electrical circuits, and mobile agents. The aim is to identify common concepts, to understand the underlying mathematical ideas, and to inspire discussions across the borders of the various disciplines. The book originates from the interdisciplinary summer school “Large Scale Networks in Engineering and Life Sciences” hosted by the International Max Planck Research School Magdeburg, September 26-30, 2011, and will therefore be of interest to mathematicians, engineers, physicists, biologists, chemists, and anyone involved in the network sciences. In particular, due to their introductory nature the chapters can serve individually or as a whole as the basis of graduate courses and seminars, future summer schools, or as reference material for practitioners in the network sciences.

This book presents an Assessment of Physical Sciences and Engineering Advances in Life Sciences and Oncology (APHELION) by a panel of experts. It covers the status and trends of applying physical sciences and engineering principles to oncology research in leading laboratories and organizations in Europe and Asia. The book elaborates on the six topics identified by the panel that have the greatest potential to advance understanding and treatment of cancer, each covered by a chapter in the book. The study was sponsored by the National Cancer Institute (NCI) at the National Institute of Health (NIH), the National Science Foundation (NSF) and the National Institute of Biomedical Imaging and Bioengineering at the NIH in the US under a cooperative agreement with the World Technology Evaluation Center (WTEC).

Approaches in Integrative Bioinformatics provides a basic introduction to biological information systems, as well as guidance for the computational analysis of systems biology. This book also covers a range of issues and methods that reveal the multitude of omics data integration types and the relevance that integrative bioinformatics has today. Topics include biological data integration and manipulation, modeling and simulation of metabolic networks, transcriptomics and phenomics, and virtual cell approaches, as well as a number of applications of network biology. It helps to illustrate the value of integrative bioinformatics approaches to the life sciences. This book is intended for researchers and graduate students in the field of Bioinformatics. Professor Ming Chen is the Director of the Bioinformatics Laboratory at the College of Life Sciences, Zhejiang University, Hangzhou, China. Professor Ralf Hofestädt is the Chair of the Department of Bioinformatics and Medical Informatics, Bielefeld University, Germany.

This book constitutes the proceedings of the 16th Brazilian Symposium on Bioinformatics on Advances in Bioinformatics and Computational Biology, BSB 2023, which took place in Curitiba, Brazil, in June 2023. The 11 full papers and 3 short papers presented in this volume were carefully reviewed and selected from 24 submissions. The papers focus on bioinformatics, computational biology, Biological Databases, Biological Networks, Cheminformatics, Evolutionary Genomics, Computational Proteomics, Systems Biology, Drug Design, Genomics, Machine Learning applications in Bioinformatics, Metagenomics, Molecular Docking and Modeling, Molecular Evolution and Phylogenetics, Protein Structure and Modeling, Proteomics, Transcriptomics, Single-Cell Analysis, Workflows in Bioinformatics.

The book focuses the latest endeavours relating researches and developments conducted in fields of Control, Robotics and Automation. Through more than twenty revised and extended articles, the present book aims to provide the most up-to-date state-of-art of the aforementioned fields allowing researcher, PhD students and engineers not only updating their knowledge but also benefiting from the source of inspiration that represents the set of selected articles of the book. The deliberate intention of editors to cover as well theoretical facets of those fields as their practical accomplishments and implementations offers the benefit of gathering in a same volume a factual and well-balanced prospect of nowadays research in those topics. A special attention toward “Intelligent Robots and Control” may characterize another benefit of this book.

This book introduces the concept of “bespoke learning”, a new mechanistic approach that makes it possible to generate values of an output variable at each designated value of an associated input variable. Here the output variable generally provides information about the system’s behaviour/structure, and the aim is to learn the input-output relationship, even though little to no information on the output is available, as in multiple real-world problems. Once the output values have been bespoke-learnt, the originally-absent training set of input-output pairs becomes available, so that (supervised) learning of the sought inter-variable relation is then possible. Three ways of undertaking such bespoke learning are offered: by tapping into system dynamics in generic dynamical systems, to learn the function that causes the system’s evolution; by comparing realisations of a random graph variable, given multivariate time series datasets of disparate temporal coverage; and by designing maximally information-availing likelihoods in static systems. These methodologies are applied to four different real-world problems: forecasting daily COVID-19 infection numbers; learning the gravitational mass density in a real galaxy; learning a sub-surface material density function; and predicting the risk of onset of a disease following bone marrow transplants. Primarily aimed at graduate and postgraduate students studying a field which includes facets of statistical learning, the book will also benefit experts working in a wide range of applications. The prerequisites are undergraduate level probability and stochastic processes, and preliminary ideas on Bayesian statistics.

The 11th volume of ToPNoC contains revised and extended versions of a selection of the best workshop papers presented at the 36th International Conference on Application and Theory of Petri Nets and Concurrency, Petri Nets 2015, and the 15th International Conference on Application of Concurrency to System Design, ACSD 2014. It also contains one paper submitted directly to ToPNoC. The 16 papers cover a diverse range of topics including model checking and system verification, refinement and synthesis; foundational work on specific classes of Petri nets; and innovative applications of Petri nets and other models of concurrency. Application areas covered in this volume are: security, service composition, communication protocols, business processes, distributed systems, and multi-agent systems. Thus, this volume gives a good overview of ongoing research on concurrent systems and Petri nets.