Lasso

Discover New Methods for Dealing with High-Dimensional DataA sparse statistical model has only a small number of nonzero parameters or weights; therefore, it is much easier to estimate and interpret than a dense model. Statistical Learning with Sparsity: The Lasso and Generalizations presents methods that exploit sparsity to help recover the underl

The untold history of the Panama Canal--from Panama's point of view. Sleuth and scholar, Marixa Lasso has uncovered a long-overlooked story: to build their Canal, Americans displaced 40,000 Panamanians and erased entire cities, only to convince the world they had brought modernity to the tropics.--

This book centers on a foundational moment for Latin American racial constructs. While most contemporary scholarship has focused the explanation for racial tolerance-or its lack-in the colonial period, Marixa Lasso argues that the key to understanding the origins of modern race relations are to be found later, in the Age of Revolution. Lasso rejects the common assumption that subalterns were passive and alienated from Creole-led patriot movements, and instead demonstrates that during Colombia's revolution, free blacks and mulattos (pardos) actively joined and occasionally even led the cause to overthrow the Spanish colonial government. As part of their platform, patriots declared legal racial equality for all citizens, and promulgated an ideology of harmony and fraternity for Colombians of all colors. The fact that blacks were mentioned as equals in the discourse of the revolution and later served in republican government posts was a radical political departure. These factors were instrumental in constructing a powerful myth of racial equality-a myth that would fuel revolutionary activity throughout Latin America. Thus emerged a historical paradox central to Latin American nation-building: the coexistence of the principle of racial equality with actual racism at the very inception of the republic. Ironically, the discourse of equality meant that grievances of racial discrimination were construed as unpatriotic and divisive acts-in its most extreme form, blacks were accused of preparing a race war. Lasso's work brings much-needed attention to the important role of the anticolonial struggles in shaping the nature of contemporary race relations and racial identities in Latin America.

Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.

"Ted Lasso" is an American comedy TV series that premiered on August 14, 2020, on Apple TV+. The show is created by Bill Lawrence, Jason Sudeikis, Joe Kelly, and Brendan Hunt, and stars Jason Sudeikis as the titular character, Ted Lasso. Ted is a cheerful and optimistic American football coach who is hired by a struggling English Premier League team, AFC Richmond, to manage their soccer team, despite having no prior experience in soccer. The series follows the misadventures of Ted Lasso, his assistant coach, Coach Beard, and the rest of the team, as they try to turn Richmond's fortunes around. The show has received widespread critical acclaim for its engaging storyline, witty writing, and brilliant acting. Critics have praised Jason Sudeikis' performance as Ted Lasso, with many calling it one of the best performances of his career. The show has been praised for its uplifting and positive message, with many viewers finding it to be a much-needed escape from the stresses of daily life. "Ted Lasso" has also been lauded for its diverse cast of characters and big-hearted approach to storytelling, making it one of the most beloved TV shows of recent times.

This is the first book to be released on Lasso that provides a step by step how to guide to creating Web solutions. The focus is on teaching essential elements of Lasso for dynamic Web content.

Welcome to The Adventures of Lasso Locks By: Caprice St. Pierre Showing the horrendous side of sexual abuse that victims every day must go through, Welcome to The Adventures of Lasso Locks shares the ugly truth. Showing the point of view of not only the victim but the predator as well, Lasso shows how a victim can heal and stop the cycle of sexual abuse.