Leucine Rich Repeat Kinase 2 Lrrk2

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert.

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields

Movement Disorders 4, the newest volume in the Blue Books in Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and pharmacologic treatment on the full range of movement disorders. Emphasizes the vast array of pharmacologic therapeutics, backed by clinical trials of the past 15 years to help you determine the best and most up-to-date drug therapy. Provides the latest on hot topics such as frontotemporal dementia and Tourette's and related disorders, keeping you up to date on today's issues. Presents the surgical management of Parkinson's Disease to help you determine when to recommend surgery and for which patients. Includes extensive comprehensive information on Parkinson's so you can better diagnose and treat PD patients. Offers more clinical details on tremors, differentiating between PD and other movement disorders and the genetics of movement disorders so you can determine which movement disorder is present.

After graduating from Tripoli, Libya in 1990, Dr Benamer came to the United Kingdom in 1991 to further his training in medicine. He obtained the MRCP in 1994 and trained in neurology in Glasgow. He obtained a PhD and CCST in 2000 and was appointed a consultant neurologist in Wolverhampton and Birmingham the same year. He has been the lead neurologist in New Cross Hospital in Wolverhampton since 2006. Dr Benamer is a general neurologist with special interest in movement disorders. Dr Benamer is honorary clinical senior lecturer in Birmingham University and has an interest in medical education, in which he obtained a postgraduate certificate from Keele University in 2007. He has published more than 35 papers and two books. He is currently a senior editor of the Libyan Journal of Medicine. He was also an examiner of the MRCP Diploma from 2005 to 2009. Dr Benamer's publications relevant to the subject of the book: 1. Benamer HT. 2007. Neurological disorders in Libya: an overview. Neuroepidemiology 29:143-9 2. Benamer HT. 2008. The ancestry of LRRK2 Gly2019Ser parkinsonism. Lancet neurology 7:769-70; author reply 70-1 3. Benamer HT, de Silva R, Siddiqui KA, Grosset DG. 2008. Parkinson's disease in Arabs: a systematic review. Movement disorders: official journal of the Movement Disorder Society 23:1205-10 4. Benamer HT, Ahmed ES, Al-Din AS, Grosset DG. 2009. Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review. Journal of the neurological sciences 278:1-4 5. Benamer HT, Grosset D. 2009. Stroke in Arab countries: a systematic literature review. Journal of the neurological sciences 284:18-23 6. Benamer HT, Grosset DG. 2009. A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia 50:2301-4 7. Benamer HT, Shakir RA. 2009. The neurology map of the Arab world. Journal of the neurological sciences 285:10-2 8. Benamer HT. 2010. Neurology expertise and postgraduate training programmes in the Arab world: a survey. European neurology 64:313-8 9. Benamer HT, de Silva R. 2010. LRRK2 G2019S in the North African population: a review. European neurology 63:321-5 10. Benamer HT, Deleu D, Grosset D. 2010. Epidemiology of headache in Arab countries. The journal of headache and pain 11:1-3 11. Benamer HT. 2011. More epidemiological studies of neurological disorders are needed in the Arab countries. Neuroepidemiology 36:70.

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.