Managing Discovery In The Life Sciences

Addresses in roughly equal measure the science and management behind several recent marketable biomedical innovations.

“I thoroughly enjoyed reading this book as it has taken me on a journey through time, across the globe and through multiple disciplines. Indeed, we need to be thinking about these concepts and applying them every day to do our jobs better.” Farah Magrabi, Macquarie University, Australia “The reader will find intriguing not only the title but also the content of the book. I’m also pleased that public health, and even more specifically epidemiology has an important place in this ambitious discussion.” Elena Andresen, Oregon Health & Science University, USA “This book is very well written and addresses an important topic. It presents many reasons why basic scientists/researchers should establish collaborations and access information outside traditional means and not limit thinking but rather expand such and perhaps develop more innovative and translational research ventures that will advance science and not move it laterally.” Gerald Pepe, Eastern Virginia Medical School, USA “This book gathers logically and presents interestingly (with many examples) the qualities and attitudes a researcher must possess in order to become successful. On the long run, the deep and carefully reexamined research will be the one that lasts.” Zoltán Néda, Babeş-Bolyai University, Romania “I really liked the five pillars delineating the components of humanism in research. This book has made a major contribution to the research ethics literature.” David Fleming, University of Missouri, USA A comprehensive review of the research phase of life sciences from design to discovery with suggestions to improve innovation This vital resource explores the creative processes leading to biomedical innovation, identifies the obstacles and best practices of innovative laboratories, and supports the production of effective science. Innovative Research in Life Sciences draws on lessons from 400 award-winning scientists and research from leading universities. The book explores the innovative process in life sciences and puts the focus on how great ideas are born and become landmark scientific discoveries. The text provides a unique resource for developing professional competencies and applied skills of life sciences researchers. The book examines what happens before the scientific paper is submitted for publication or the innovation becomes legally protected. This phase is the most neglected but most exciting in the process of scientific creativity and innovation. The author identifies twelve competencies of innovative biomedical researchers that described and analyzed. This important resource: Highlights the research phase from design to discovery that precedes innovation disclosure Offers a step by step explanation of how to improve innovation Offers solutions for improving research and innovation productivity in the life sciences Contains a variety of statistical databases and a vast number of stories about individual discoveries Includes a process of published studies and national statistics of biomedical research and reviews the performance of research labs and academic institutions Written for academics and researchers in biomedicine, pharmaceutical science, life sciences, drug discovery, pharmacology, Innovative Research in Life Sciences offers a guide to the creative processes leading to biomedical innovation and identifies the best practices of innovative scientists and laboratories.

Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters

Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry. Considers drug discovery in multiple R&D venues, including big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable

This volume offers selected papers exploring issues arising from scientific discovery in the social sciences. It features a range of disciplines including behavioural sciences, computer science, finance, and statistics with an emphasis on philosophy. The first of the three parts examines methods of social scientific discovery. Chapters investigate the nature of causal analysis, philosophical issues around scale development in behavioural science research, imagination in social scientific practice, and relationships between paradigms of inquiry and scientific fraud. The next part considers the practice of social science discovery. Chapters discuss the lack of genuine scientific discovery in finance where hypotheses concern the cheapness of securities, the logic of scientific discovery in macroeconomics, and the nature of that what discovery with the Solidarity movement as a case study. The final part covers formalising theories in social science. Chapters analyse the abstract model theory of institutions as a way of representing the structure of scientific theories, the semi-automatic generation of cognitive science theories, and computational process models in the social sciences. The volume offers a unique perspective on scientific discovery in the social sciences. It will engage scholars and students with a multidisciplinary interest in the philosophy of science and social science.

This book constitutes the refereed proceedings of the 10th International Conference on Data Integration in the Life Sciences, DILS 2014, held in Lisbon, Portugal, in July 2014. The 9 revised full papers and the 5 short papers included in this volume were carefully reviewed and selected from 20 submissions. The papers cover a range of important topics such as data integration platforms and applications; biodiversity data management; ontologies and visualization; linked data and query processing.

This book constitutes the thoroughly refereed post-conference proceedings of the Second International Joint Conference on Knowledge Discovery, Knowledge Engineering, and Knowledge Management, IC3K 2010, held in Valencia, Spain, in October 2010. This book includes revised and extended versions of a strict selection of the best papers presented at the conference; 26 revised full papers together with 2 invited lectures were carefully reviewed and selected from 369 submissions. According to the three covered conferences KDIR 2010, KEOD 2010, and KMIS 2010, the papers are organized in topical sections on knowledge discovery and information retrieval, knowledge engineering and ontology development, and on knowledge management and information sharing.

The COVID-19 pandemic has reminded us of how important the life science industry is, and compels us to find efficient management methods specific to the industry. Pharmaceuticals, drug and vaccine development labs, R&D labs, medical instrumentation, and tech companies, hygiene supply companies, medical distribution chains, all form an integral part of this industry. At the interface of scientific research, technology, innovation and management and embedded in regulatory and legal frameworks, life science management is still an under-researched field of practice and science. This edited volume addresses this research gap and offers a wide range of practical and theoretical contributions that provide insights into one of the most exciting industries. The book is primarily directed at practitioners and decision makers in the life science industry. Students and professionals of life science management at all levels as well as policy makers will find valuable insights and inspiration for their daily work and career development.