Medicinal Chemistry Of Chemotherapeutic Agents
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Medicinal Chemistry of Chemotherapeutic Agents
Author | : Pratap Chandra Acharya,Michio Kurosu |
Publsiher | : Academic Press |
Total Pages | : 688 |
Release | : 2023-03-09 |
Genre | : Medical |
ISBN | : 9780323907019 |
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Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents. Includes current research focused on drug resistance and methods to overcome problems Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents Discusses molecules under clinical trials and newly approved drugs
Medicinal Chemistry of Anticancer Drugs
Author | : Carmen Avendaño,J. Carlos Menéndez |
Publsiher | : Elsevier |
Total Pages | : 767 |
Release | : 2015-06-11 |
Genre | : Science |
ISBN | : 9780444626677 |
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Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature
CRC Handbook of Chemotherapeutic Agents
Author | : Chemical Rubber Company |
Publsiher | : Unknown |
Total Pages | : 374 |
Release | : 1986 |
Genre | : Anti-infective agents |
ISBN | : UOM:39015010156209 |
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CRC Handbook of Chemotherapeutic Agents
Author | : Chemical Rubber Company (Cleveland, Ohio),Matthew Verderame |
Publsiher | : C R C Press Reprints |
Total Pages | : 354 |
Release | : 1986 |
Genre | : Anti-infective agents |
ISBN | : 0849332850 |
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Medicinal Chemistry
Author | : Norma K Dunlap,Donna M Huryn |
Publsiher | : Garland Science |
Total Pages | : 991 |
Release | : 2018-04-17 |
Genre | : Medical |
ISBN | : 9781351586207 |
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Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry.
Medicinal Chemistry
Author | : A. Burger |
Publsiher | : Unknown |
Total Pages | : 915 |
Release | : 1970 |
Genre | : Electronic Book |
ISBN | : OCLC:925969697 |
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Anticancer Therapeutics
Author | : Adam Todd,Paul W. Groundwater,Jason H. Gill |
Publsiher | : John Wiley & Sons |
Total Pages | : 446 |
Release | : 2018-02-20 |
Genre | : Science |
ISBN | : 9781118622124 |
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An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.
Medicinal Chemistry
Author | : A.K. Ganguly,Sesha Sridevi Alluri |
Publsiher | : CRC Press |
Total Pages | : 163 |
Release | : 2021-09-12 |
Genre | : Medical |
ISBN | : 9781000437287 |
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Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.