Metallic Biomaterials For Medical Applications

Metallic Biomaterials Processing and Medical Device Manufacturing details the principles and practices of the technologies used in biomaterials processing and medical device manufacturing. The book reviews the main categories of metallic biomaterials and the essential considerations in design and manufacturing of medical devices. It bridges the gap between the designing of biomaterials and manufacturing of medical devices including requirements and standards. Main themes of the book include, manufacturing, coatings and surface modifications of medical devices, metallic biomaterials and their mechanical behaviour, degradation, testing and characterization, and quality controls, standards and FDA regulations of medical devices. The leading experts in the filed discuss the requirements, challenges, recent progresses and future research directions in the processing of materials and manufacturing of medical devices. Metallic Biomaterials Processing and Medical Device Manufacturing is ideal for those working in the disciplines of materials science, manufacturing, biomedical engineering, and mechanical engineering. Reviews key topics of biomaterials processing for medical device applications including metallic biomaterials and their mechanical behavior, degradation, testing and characterization Bridges the gap between biomaterials design and medical device manufacturing Discusses the quality controls, standards, and FDA requirements for biomaterials and medical devices

The book presents the characterization and classification of metallic biomaterials; with focus on titanium-based alloys, cobalt-based alloys, stainless steels and biodegradable alloys. Emphasis is placed on the synthesis, assessment of properties and medical applications such as multifunctional implants. The book references 423 original resources and includes their direct web link for in-depth reading. Keywords: Biomaterials, Classification, Titanium Alloys, Cobalt Alloys, Stainless Steels, Biodegradable Alloys, Medical Applications, Optimization of Metallic Biomaterials, Multifunctional Implants, Tissue Reactions, Toxicity of Metals, Inflammatory Reactions, Immunological Reactions, Sensibility, Allergy, Carcinogenic Effects, Ceramic Coatings, Ionic Implantation in Plasma, Biocompatibility.

Metals for Biomedical Devices, Second Edition, has been fully updated and builds upon the success of its first edition, discussing the latest techniques in metal processing methods and the behavior of this important material. Initial chapters review the current status and selection of metals for biomedical devices. Subsequent chapters cover mechanical behavior, degradation and testing, corrosion, wear testing and biocompatibility, the processing of metals for biomedical applications, including topics such as forging metals and alloys, surface treatment, coatings and sterilization. Chapters in the final section discuss the clinical applications of metals, such as cardiovascular, orthopedic and new generation biomaterials. With its distinguished editor and team of expert contributors, this book is a standard reference for materials scientists, researchers and engineers working in the medical devices industry and academia. Reviews the latest techniques in metal processing methods, including surface treatment and sterilization Examines metal selection for biomedical devices, considering the biocompatibility of various metals Assesses mechanical behavior and the testing of metals, featuring the latest information on corrosion, fatigue and wear Discusses biodegradable alloys, including a new section on Mg alloys Includes a new section that discusses the use of additive manufacturing in the production of medical devices

The book presents the state-of-the-art of biomaterials used in the human body and reports new research on various Ti-based alloys with non-toxic elements (Mo, Zr, Ta, Si, Nb, etc.) aimed at improved mechanical properties, corrosion resistance and biocompatibility. Specific laboratory tests are reported for structural characterization, mechanical properties and corrosion resistance testing, and cytotoxicity assessment. Keywords: Titanium Alloys, Biomedical Materials, Cytotoxicity Assessment, Biocompatibility, Production and Properties of Ti-Mo-Zr-Ta Alloys, Surface Modification, Powder Metallurgy, Characterization of Ti-Mo-Zr-Ta-Alloys, Mechanical Properties, Differential Scanning Calorimetry, Electrochemical Behavior, Optical Microstructure, X-ray Diffraction, Thermal Characterization, Corrosion Resistance, Medical Applications.

This book in the emerging research field of biomaterials covers biodegradable metals for biomedical applications. The book contains two main parts where each of them consists of three chapters. The first part introduces the readers to the field of metallic biomaterials, exposes the state of the art of biodegradable metals, and reveals its application for cardiovascular implants. Some fundamental aspects to give basic understanding on metals for further review on the degradable ones is covered in chapter one. The second chapter introduces the concept of biodegradable metals, it's state of the art and discuses a shifted paradigm from inert to bioactive, from corrosion resistant to corrodible metals. The third chapter focuses on the challenges and opportunities of using biodegradable metals for cardiovascular applications. The second part exposes an example of biodegradable metals from its concept to applications where a complete study on metallic biodegradable stent is detailed from materials design, development, testing till the implant fabrication. The forth chapter reveals new alloys development devoted for metallic biodegradable stent based on required criteria derrived from clinical needs and current nondegradable stents properties. Degradation of the alloys in simulated arterial conditions and its effect to cells are exposed in chapter five. The both chapters are concluded with a benchmarking of some more recent researches on materials development and testing for biodegradable stents. Chapter six reveals the tranformation process of the materials into stent prototypes where a standard process for making 316L stainless steel stents was followed. The book is completed by a perspective on the use of biodegradable metals for biomedical applications in the era of tissue engineering.

Precious metals and semi-precious metals are used for an increasing number of medical applications due to the properties of these metals and their alloys. Precious Metals for Biomedical Applications reviews the properties of precious metals and their resulting applications in medicine. Part one outlines the fundamentals of precious metals for biomedical applications, discussing their useful properties, such as biocompatibility and corrosion resistance. Part two goes on to provide an overview of the applications of precious metals in biomedicine, including dental, therapeutic, tissue engineering, and bioimaging applications. It discusses the advantages of the structure and properties of precious metals for these applications. Precious Metals for Biomedical Applications is a key reference for material scientists and academics concerned with the properties and uses of these metals. Provides a useful review of this group of materials’ unique properties and applications Examines the fundamentals of precious metals for biomedical applications, before looking at a wide range of applications of precious metals in medicine

This book reviews fundamental advances in the use of metallic biomaterials to reconstruct hard tissues and blood vessels. It also covers the latest advances in representative metallic biomaterials, such as stainless steels, Co-Cr alloys, titanium and its alloys, zirconium, tantalum and niobium based alloys. In addition, the latest findings on corrosion, cytotoxic and allergic problems caused by metallic biomaterials are introduced. The book offers a valuable reference source for researchers, graduate students and clinicians working in the fields of materials, surgery, dentistry, and mechanics. Mitsuo Niinomi, PhD, D.D.Sc., is a Professor at the Institute for Materials Research, Tohoku University, Japan. Takayuki Narushima, PhD, is a Professor at the Department of Materials Processing, Tohoku University, Japan. Masaaki Nakai, PhD, is an Associate Professor at the Institute for Materials Research, Tohoku University, Japan.