Micro Drops And Digital Microfluidics

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops." A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow) A fresh perspective on the future of microfluidics

In this 2nd edition of Micro-Drops and Digital Microfluidics, Jean Berthier explores the fundamentals and applications of digital microfluidics, enabling engineers and scientists to design this important enabling technology into devices and harness the considerable potential of digital microfluidics in testing and data collection. This book describes the most recent developments in digital microfluidics, with a specific focus on the computational, theoretical and experimental study of microdrops. Unique in its emphasis on digital microfluidics and with diverse applications ranging from drug delivery to point-of-care diagnostic chips, organic synthesis to microreactors, Micro-Drops and Digital Microfluidics meets the needs of audiences across the fields of bioengineering and biotechnology, and electrical and chemical engineering. . Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops."" . A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates. . A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces. . Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow). . A fresh perspective on the future of microfluidics.

The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics.Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods.This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation.

Droplet and Digital Microfluidics: Ideation to Implementation is a detailed introduction to the dynamics of droplet and digital microfluidics, also featuring coverage of new methods and applications. The explosion of applications of microelectromechanical systems (MEMS) in recent years has driven demand for expertise and innovation in fluid flow in the microchannels they contain. In this book, detailed descriptions of methods for biological and chemical applications of microfluidics are provided, along with supporting foundational knowledge. In addition, the principles of droplet and digital microfluidics are explained, along with their different applications and governing physics. New additions to the technological knowledgebase that enable advances in droplet and digital microfluidics include machine learning and exciting future avenues for research. Provides step-by-step fabrication, testing, and characterization instructions in each chapter to support implementation Includes explanations of applications and methods in biological and chemical settings Describes the path to automation of digital and droplet microfluidic platforms

This book provides an insightful guide to the design, testing and optimization of micro-electrode-dot-array (MEDA) digital microfluidic biochips. The authors focus on the characteristics specific for MEDA biochips, e.g., real-time sensing and advanced microfluidic operations like lamination mixing and droplet shape morphing. Readers will be enabled to enhance the automated design and use of MEDA and to develop a set of solutions to facilitate the full exploitation of design complexities that are possible with standard CMOS fabrication techniques. The book provides the first set of design automation and test techniques for MEDA biochips. The methods described in this book have been validated using fabricated MEDA biochips in the laboratory. Readers will benefit from an in-depth look at the MEDA platform and how to combine microfluidics with software, e.g., applying biomolecular protocols to software-controlled and cyberphysical microfluidic biochips.

Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.

This book constitutes the refereed proceedings of the 21st International Symposium on VLSI Design and Test, VDAT 2017, held in Roorkee, India, in June/July 2017. The 48 full papers presented together with 27 short papers were carefully reviewed and selected from 246 submissions. The papers were organized in topical sections named: digital design; analog/mixed signal; VLSI testing; devices and technology; VLSI architectures; emerging technologies and memory; system design; low power design and test; RF circuits; architecture and CAD; and design verification.

This book presents the lecture notes of the 1st Summer School on Methods and Tools for the Design of Digital Systems, 2015, held in Bremen, Germany. The topic of the summer school was devoted to modeling and verification of cyber-physical systems. This covers several aspects of the field, including hybrid systems and model checking, as well as applications in robotics and aerospace systems. The main chapters have been written by leading scientists, who present their field of research, each providing references to introductory material as well as latest scientific advances and future research directions. This is complemented by short papers submitted by the participating PhD students.