Micro Nano Devices For Blood Analysis

The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.

The development of micro- and nanodevices for blood analysis continues to be a growing interdisciplinary subject that demands the careful integration of different research fields. Following the success of the book "Micro/Nano Devices for Blood Analysis", we invited more authors from the scientific community to participate in and submit their research for a second volume. Researchers from different areas and backgrounds cooperated actively and submitted high-quality research, focusing on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis; micro- and nanofluidics; technologies for flow visualization and diagnosis; biochips, organ-on-a-chip and lab-on-a-chip devices; and their applications to research and industry.

The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.

This book is a printed edition of the Special Issue "Micro/Nano Devices for Chemical Analysis" that was published in Micromachines

Blood is a type of body fluid found in the circulatory system of human beings and other vertebrates. It carries essential substances including oxygen and nutrients to the cells. It also carries-back the metabolic waste products and carbon dioxide from the cells to lungs, kidneys and digestive system to be removed by the body. Blood analysis refers to the laboratory investigation of a blood sample that helps to gather information about its chemical and physical properties. For carrying out blood analysis, blood sample is drawn from the veins of fingers, arms or earlobes. In certain cases, the blood cells of the bone marrow might also be examined. Micro devices have great potential for the growth of portable and point-of-care diagnostic devices, specifically for blood analysis. The development of micro and nano devices for the analysis of blood integrates numerous research fields including electronics, micro or nanotechnologies, medicine, informatics, mechanics, biotechnology, chemistry and optics. This book explores all the important aspects of blood analysis devices in the present day. It is a valuable compilation of topics, ranging from the basic to the most complex advancements in the field of hematology. The readers would gain knowledge that would broaden their perspective in this area.

Biosensors Based on Nanomaterials and Nanodevices links interdisciplinary research from leading experts to provide graduate students, academics, researchers, and industry professionals alike with a comprehensive source for key advancements and future trends in nanostructured biosensor development. It describes the concepts, principles, materials, device fabrications, functions, system integrations, and applications of various types of biosensors based on signal transduction mechanisms, including fluorescence, photonic crystal, surface-enhanced Raman scattering, electrochemistry, electro-luminescence, field-effect transistor, and magnetic effect. The book: Explains how to utilize the unique properties of nanomaterials to construct nanostructured biosensors to achieve enhanced performance Features examples of biosensors based on both typical and emerging nanomaterials, such as gold nanoparticles, quantum dots, graphene, graphene oxides, magnetic nanoparticles, carbon nanotubes, inorganic nanowires/nanorods, plasmonic nanostructures, and photonic crystals Demonstrates the broad applications of nanostructured biosensors in environmental monitoring, food safety, industrial quality assurance, and in vitro and in vivo health diagnosis Inspires new ideas for tackling multiscale and multidisciplinary issues in developing high-performance biosensors for complex practical biomedical problems Focusing on the connection between nanomaterials research and biosensor development, Biosensors Based on Nanomaterials and Nanodevices illustrates the exciting possibilities and critical challenges of biosensors based on nanomaterials and nanodevices for future health monitoring, disease diagnosis, therapeutic treatments, and beyond.

This major work has established itself as the definitive reference in the nanoscience and nanotechnology area in one volume. In presents nanostructures, micro/nanofabrication, and micro/nanodevices. Special emphasis is on scanning probe microscopy, nanotribology and nanomechanics, molecularly thick films, industrial applications and microdevice reliability, and on social aspects. Reflecting further developments, the new edition has grown from six to eight parts. The latest information is added to fields such as bionanotechnology, nanorobotics, and NEMS/MEMS reliability. This classic reference book is orchestrated by a highly experienced editor and written by a team of distinguished experts for those learning about the field of nanotechnology.

Micro-nanotechnologies (MNT) are already making a profound impact on our daily lives. New applications are well underway in the US, Asia, and Europe. However, their potentially disruptive nature, along with the public’s concerns, has produced a number of challenges. Commercializing Micro-Nanotechnology Products provides a snapshot of the current market situation and details the need for MNT development. It outlines the problems facing today’s businesses and discusses the processes for commercialization, road mapping, technology transfer analysis, and entrepreneurial development. The book begins by detailing the steps required to turn an idea into a marketable product. The editors give examples of previously successful products and relate to their own experiences in development. Next, the text focuses on the importance of entrepreneurship and the required steps to finance and develop a marketing strategy. It contains various definitions of nanotechnology and how each relates to roadmap and production issues. Three detailed case studies from the leading MNT development and manufacturing companies describe how each venture started and progressed to become a market leader. These studies offer valuable insight into overcoming the challenges related to achieving financial backing and specifying the right product for development. This reference provides the only insightful appraisal of the current status of micro-nanotechnology products. It describes a concise process for product commercialization, from market research to end product realization. Commercializing Micro-Nanotechnologies provides a clear strategy for choosing the right product to development and overcoming challenges in the growing global market.