Model Based Inference In The Life Sciences

This textbook introduces a science philosophy called "information theoretic" based on Kullback-Leibler information theory. It focuses on a science philosophy based on "multiple working hypotheses" and statistical models to represent them. The text is written for people new to the information-theoretic approaches to statistical inference, whether graduate students, post-docs, or professionals. Readers are however expected to have a background in general statistical principles, regression analysis, and some exposure to likelihood methods. This is not an elementary text as it assumes reasonable competence in modeling and parameter estimation.

This handbook offers the first comprehensive reference guide to the interdisciplinary field of model-based reasoning. It highlights the role of models as mediators between theory and experimentation, and as educational devices, as well as their relevance in testing hypotheses and explanatory functions. The Springer Handbook merges philosophical, cognitive and epistemological perspectives on models with the more practical needs related to the application of this tool across various disciplines and practices. The result is a unique, reliable source of information that guides readers toward an understanding of different aspects of model-based science, such as the theoretical and cognitive nature of models, as well as their practical and logical aspects. The inferential role of models in hypothetical reasoning, abduction and creativity once they are constructed, adopted, and manipulated for different scientific and technological purposes is also discussed. Written by a group of internationally renowned experts in philosophy, the history of science, general epistemology, mathematics, cognitive and computer science, physics and life sciences, as well as engineering, architecture, and economics, this Handbook uses numerous diagrams, schemes and other visual representations to promote a better understanding of the concepts. This also makes it highly accessible to an audience of scholars and students with different scientific backgrounds. All in all, the Springer Handbook of Model-Based Science represents the definitive application-oriented reference guide to the interdisciplinary field of model-based reasoning.

This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.

Despite the available general literature in intelligent control, there is a definite lack of knowledge and know-how in practical applications of intelligent control in drying. This book fills that gap. Intelligent Control in Drying serves as an innovative and practical guide for researchers and professionals in the field of drying technologies, providing an overview of control principles and systems used in drying operations, from classical to model-based to adaptive and optimal control. At the same time, it lays out approaches to synthesis of control systems, based on the objectives and control strategies, reflecting complexity of drying process and material under drying. This essential reference covers both fundamental and practical aspects of intelligent control, sensor fusion and dynamic optimization with respect to drying.

This practical manual of freshwater ecology and conservation provides a state-of-the-art review of the approaches and techniques used to measure, monitor, and conserve freshwater ecosystems. It offers a single, comprehensive, and accessible synthesis of the vast amount of literature for freshwater ecology and conservation that is currently dispersed in manuals, toolkits, journals, handbooks, 'grey' literature, and websites. Successful conservation outcomes are ultimately built on a sound ecological framework in which every species must be assessed and understood at the individual, community, catchment and landscape level of interaction. For example, freshwater ecologists need to understand hydrochemical storages and fluxes, the physical systems influencing freshwaters at the catchment and landscape scale, and the spatial and temporal processes that maintain species assemblages and their dynamics. A thorough understanding of all these varied processes, and the techniques for studying them, is essential for the effective conservation and management of freshwater ecosystems.

“Until recently, inferring identities of predators and monitoring cryptic behaviors at the nest was time-consuming, often with anecdotal results. No more. Video nest surveillance, so aptly revealed in this volume, has ushered in a new era of data collection that allows field workers to link environmental factors with such aspects as the temporal dynamics of predator communities in relation to what the birds are doing at their nests, thus removing much of the guesswork of earlier studies.”--Spencer G. Sealy, University of Manitoba "Video Surveillance of Nesting Birds shatters earlier beliefs about how birds interact with nest predators. Much of what we thought we knew about nesting and its hazards was flat-out wrong, as authors in this book discovered by using modern technology in the field. As simple as we would like our models of animal behavior to be, this book shows that reality is far more complex and nuanced."--Douglas H. Johnson, University of Minnesota

Succinct, user-friendly, thoroughly referenced and prepared by leading experts in the field, this book is the only single textbook you will need to succeed in the Royal College of Psychiatrists' MRCPsych and other related higher examinations. Chapters follow the structure and syllabus of the examination ensuring that you receive the necessary essential information to pass and indeed succeed Approachable and succinct text with colour illustrations and key summary points further help to clarify complex concepts and provide you with useful revision tools The evidence-based approach used throughout is important to help you relate theory and research to clinical practice The book is carefully structured and sequenced to building upon the basic sciences underpinning psychiatry, through to an in-depth description of pharmacological and psychological treatments used.

Diffusion processes are a promising instrument for realistically modelling the time-continuous evolution of phenomena not only in the natural sciences but also in finance and economics. Their mathematical theory, however, is challenging, and hence diffusion modelling is often carried out incorrectly, and the according statistical inference is considered almost exclusively by theoreticians. This book explains both topics in an illustrative way which also addresses practitioners. It provides a complete overview of the current state of research and presents important, novel insights. The theory is demonstrated using real data applications.