Nasa Human Spaceflight Astronaut Health Research For Exploration And Manned Mars Missions Risk Report Wsn 03 Intervertebral Disc Damage Altered Immune Response Cardiac Rhythm Osteoporosis

This series of reports deals with ongoing research by NASA into a risk reduction strategy for human space exploration and planned manned missions to Mars. Each report deals with a unique aspect of the human research needed to pursue long-duration missions. Many of the reports contain exclusive details about medical events impacting astronauts and cosmonauts on earlier flights, including Mir, Space Shuttle, and ISS Space Station missions. Each risk Evidence Report contains a narrative discussion of the risk and its supporting evidence. All cited publicly-available references are listed at the end of the report. In addition, data that are significant or pivotal are summarized in text, tables, and charts in sufficient detail to allow the reader to critique the data and draw conclusions. The authors also indicate whether the data are from human, animal, or tissue, cellular, or molecular studies. The reports discuss evidence from both spaceflight (including biomedical research, Medical Requirements Integration Document [MRID] data, and operational performance or clinical observations) and ground (including space analog research and non-space analog biomedical or clinical research) research. When providing evidence from ground-based studies, authors discuss why these results are likely to be applicable in the space environment, offering any available validation information for the use of these ground-based systems. Reports included in this compilation: Evidence Book: Risk of Intervertebral Disc Damage * Evidence Report: Risk of Crew Adverse Health Event Due to Altered Immune Response * Evidence Based Review: Risk of Cardiac Rhythm Problems during Space Flight * Evidence Book: Risk of Accelerated Osteoporosis There is a large body of evidence associated with immune dysregulation and spaceflight. However, current studies onboard the International Space Station (ISS) that are defining space normal for the human immune system remain insufficient to determine clinical risk during exploration space missions. In particular, more in-flight studies are needed using human subjects. Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The HRP utilizes various research platforms to conduct research. Ground research occurs in laboratories and analogs that mimic a portion of the spaceflight environment. In addition, the International Space Station (ISS) is used to conduct research requiring the unique environment of space.

The success of any space flight mission depends not only on advanced technology but also on the health and well-being of crew members. This book, written by an astronaut physician, is the first practical guide to maintaining crew members health in space. It combines research results with practical advice on such problems as bone loss, kidney stones, muscle wasting, motion sickness, loss of balance, orthostatic intolerance, weight loss, and excessive radiation exposure. Additional topics include pre-flight preparation, relevant gender differences, long-duration medical planning, post-flight rehabilitation, and the physiology of extra-vehicular activity. Designed as a handbook for space crews, this text is also an invaluable tool for all the engineers, medical personnel, and scientists who plan and execute space missions.

Summarizes the advances in cryoelectronics starting from the fundamentals in physics and semiconductor devices to electronic systems, hybrid superconductor-semiconductor technologies, photonic devices, cryocoolers and thermal management. This book provides an exploration of the theory, research, and technologies related to cryoelectronics.

Agencies participating in the International Space Exploration Coordination Group (ISECG) continue to advance a long-range international exploration strategy that begins with the International Space Station (ISS) and expands human presence in the solar system, leading ultimately to human missions to explore the surface of Mars.The Global Exploration Roadmap, first released in September 2011, has been updated in August 2013 to reflect updated agency plans and programmes as well as continue to facilitate stakeholder engagement in the effort to chart an international roadmap to Mars. Figures. This is a print on demand report.

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